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Skeleton and Joint Degeneration with Aging
PROJECT SUMMARY/ABSTRACT Decreased mobility significantly increases the risk of many chronic diseases leading to an acceleration of the normal aging process. Skeletal degeneration,...
Admin Core
Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75-years), primarily through the elimination of lives lost due to premature...
In Vivo Model and Histology Core
PROJECT SUMMARY The purpose of the in vivo Animal model & histology core is to consolidate key personnel and equipment to provide a centralized facility that will enhance colla...
Endplate Sensory Innervations for LBP
ABSTRACTPersistent pain, particularly at rest, profoundly affects quality of life and daily physical activity, especially in the elderly population. Pain itself is a risk factor fo...
PTH Attenuation of Spinal Degeneration During Aging PI Janet Crane
SUMMARY Low back pain is the leading cause of disability, driven predominantly by aging. Pain contributes to frailty by lowering quality of life and limiting physical activities. I...
Senescence of Pre-Osteoclasts in Non-Traumatic OA
SUMMARY/ABSTRACT Osteoarthritis (OA) is the most prevalent age-associated chronic joint disease. Although direct joint injury and excessive mechanical overloading are considered as...
Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention
The prevalence of Alzheimer's Disease and other disorders (ADRDs) is now a public health crisis. In the absence of effective medical treatment, there is a critical need for be...
ENIGMA World Aging Center
ABSTRACTOne in three seniors dies with Alzheimer’s disease (AD) or another dementia - diseases that cost the nation $259 billion, to rise to $1.1 trillion by 2050 (Alzheimer’s Asso...
Molecular mechanisms underlying cortical interneuron synaptic specificity
Project Summary/Abstract Cortical inhibitory GABAergic interneurons (INs), which develop intricate local circuits, critically regulate higher- order brain functions by balancing an...
Structure and function of mammalian CPEB2 aggregates in normal and AD brain
Project Summary The aggregate failure of pre-clinical and clinical trials in AD has demonstrated that an improved fundamental understanding of memory and how the molecular componen...
Humanization of a Notch 3 Agonist Antibody for Pre-Clinical Development of a CADASIL Treatment
PROJECT SUMMARY Notch 3 mutations are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a small vessel disease char...
Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults
OTHER PROJECT INFORMATION – Project Summary/Abstract Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults The rapid aging of the U.S. population, with...
The impact of post acute care payment changes on access and outcomes
Project Summary/Abstract Substantial changes in Medicare payment policies are occurring for post-acute care (PAC), which provides a bridge from the hospital to home for individuals...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...
Localizing and modulating competing memories of fear and safety in the human brain
PROJECT SUMMARY. Pathologies characterized by excessive fear and anxiety are the most common mental illness with a 12-month prevalence estimate of about 40 million American adults....
Skeleton and Joint Degeneration with Aging
PROJECT SUMMARY/ABSTRACT Decreased mobility significantly increases the risk of many chronic diseases leading to an acceleration of the normal aging process. Skeletal degeneration,...
Admin Core
Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75-years), primarily through the elimination of lives lost due to premature...
In Vivo Model and Histology Core
PROJECT SUMMARY The purpose of the in vivo Animal model & histology core is to consolidate key personnel and equipment to provide a centralized facility that will enhance colla...
Endplate Sensory Innervations for LBP
ABSTRACTPersistent pain, particularly at rest, profoundly affects quality of life and daily physical activity, especially in the elderly population. Pain itself is a risk factor fo...
PTH Attenuation of Spinal Degeneration During Aging PI Janet Crane
SUMMARY Low back pain is the leading cause of disability, driven predominantly by aging. Pain contributes to frailty by lowering quality of life and limiting physical activities. I...