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99,167 grants found
Showing 97,361 – 97,380 of 99,167 grants
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Statement of Work A study coordinator is being hired for the current R01 award and was originally budgeted for 35 hrs/week. For the supplement we will increase this to 40 hrs/week...
The Progressive Elevation of Spontaneous Cortical Activity in HAND (PESCAH) Project
Project Summary/Abstract It is well known that human cortical neurons exhibit spontaneous firing in the absence of incoming exogenous and endogenous input. Across a neuronal popula...
Molecular mechanisms underlying cortical interneuron synaptic specificity
Project Summary/Abstract Cortical inhibitory GABAergic interneurons (INs), which develop intricate local circuits, critically regulate higher- order brain functions by balancing an...
Genetic Predictors of Prostate Cancer Survival
Prostate cancer (PC) has a very heterogenous clinical course. Many men have an indolent PC that can be safely watched for years without progression. Alternatively, other men have a...
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
PROJECT SUMMARY / ABSTRACT Staphylococcus epidermidis is a ubiquitous member of the human skin and mucosal microbiota. Functionally, it is a key contributor to human health via imm...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Intimate partner violence (IPV), the physical violence, sexual violence, psychological aggression, or stalking by a current or former intimate partner, is a significant public heal...
Genetic predictors of prostate cancer survival
PROJECT SUMMARY/ABSTRACT The underlying scientific premise of the parent grant is that the risk factors and mechanisms that drive prostate cancer development likely differ from tho...
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults at Risk of Alzheimer's Disease and Related Dementias
PROJECT SUMMARY The overall objective of the proposed work is to understand factors mediating and moderating transfer of learning in the context of training Working Memory (WM) sys...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug targets a...
Add Health as a Resource for the Science of the Exposome and Risk for AD/ADRD
Project Summary This supplement to U01 AG071450 responds to NOT-AG-22-022, which lays out the “urgent need for research infrastructure that addresses the role of diverse physical,...
Personalized Dietary Management in Type 2 Diabetes
Abstract Hyperglycemia in type 2 diabetes (T2D) is associated with a variety of vascular complications of the disease, but clinical trials of medication regimens designed to achiev...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plasticit...
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning Summa...
Engineering a novel biomaterial for oxygen transport applications
Abstract Hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant c...
Single cell, whole genome analysis of the aging human cardiomyocyte
Project Summary/Abstract Recent evidence suggests that environmental factors causing somatic mutations during the lifetime have a more crucial role, not only in cancer but also in...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug targets a...
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI
ABSTRACT Traumatic brain injury (TBI) is significantly correlated with increased risk for developing several neurodegenerative disorders, including Alzheimer’s Disease (AD) and AD-...
Structure and function of mammalian CPEB2 aggregates in normal and AD brain
Project Summary The aggregate failure of pre-clinical and clinical trials in AD has demonstrated that an improved fundamental understanding of memory and how the molecular componen...