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99,167 grants found
Showing 97,501 – 97,520 of 99,167 grants
Novel dual-targeted inhibitors of EGFR and aurora kinase for lung cancer
PROJECT SUMMARY Small molecule EGFR inhibitors constitute the recommended therapy for EGFR-positive non-small cell lung cancer (NSCLC).Resistance was first reported to EGFR inhibit...
Social Networks of Diffusion and Adoption: Investigating the Network Effects on implementation of evidence-based interventions for early intervention providers of children
Early interventions for preschoolers with Autism Spectrum Disorder (ASD) can result in substantial improvements across cognitive and communication outcomes.1 However, treatment res...
Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1
MASSI/ BOSCO ?ABSTRACT Profilin-1 (PFN1) is a 15kDa actin-binding protein that plays a critical role in regulating cytoskeletal dynamics. In order to promote actin polymerization i...
Longitudinal Antibody Profiles Correlated with Protection from Malaria in Malawi
PROJECT SUMMARY Malaria continues to be responsible for substantial childhood mortality in Africa despite current control efforts.Developing an effective vaccine for malaria elimin...
Intratumor co-delivery of DNA and RNA to relieve cancer pain
Oral cancer causes more prevalent and severe pain than any other cancer.Oral cancer patients suffer from severe, chronic, mechanically-induced pain; talking and eating are profound...
Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1
MASSI/ BOSCO – ABSTRACT Profilin-1 (PFN1) is a 15kDa actin-binding protein that plays a critical role in regulating cytoskeletal dynamics. In order to promote actin polymerization...
A Glucocorticoid Receptor-SETDB2 Co-Regulated Liver Metabolic Gene Program
Excess glucocorticoids contribute to the development of diabetes and metabolic syndrome, which includes: obesity, hyperglycemia, hypercholesterolemia, insulin resistance, and liver...
A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart
Project Summary/Abstract Loss of cardiomyocytes by apoptosis and/or necrosis is a hallmark of cardiac ischemic injury, pathological remodeling, and end-stage heart failure. Althoug...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
A microbiome-dependent bile acid metabolite improves type 2 diabetes.
Project Summary/Abstract The molecular mechanisms that explain the potent anti-diabetic effects of bariatric surgery remain elusive. The rapid nature of type 2 diabetes mellitus (T...
Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure
Heart failure (HF) is the most common reason for hospitalization and death among those older than 65-years, and statistic is projected to grow as our population ages. The socioecon...
Social Networks of Diffusion and Adoption: Investigating the Network Effects on implementation of evidence-based interventions for early intervention providers of children
Early interventions for preschoolers with Autism Spectrum Disorder (ASD) can result in substantial improvements across cognitive and communication outcomes.1 However, treatment res...
Longitudinal Antibody Profiles Correlated with Protection from Malaria in Malawi
PROJECT SUMMARY Malaria continues to be responsible for substantial childhood mortality in Africa despite current control efforts. Developing an effective vaccine for malaria elimi...
Intratumor co-delivery of DNA and RNA to relieve cancer pain
Oral cancer causes more prevalent and severe pain than any other cancer. Oral cancer patients suffer from severe, chronic, mechanically-induced pain; talking and eating are profoun...
Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1
MASSI/ BOSCO – ABSTRACT Profilin-1 (PFN1) is a 15kDa actin-binding protein that plays a critical role in regulating cytoskeletal dynamics. In order to promote actin polymerization...
A Glucocorticoid Receptor-SETDB2 Co-Regulated Liver Metabolic Gene Program
Excess glucocorticoids contribute to the development of diabetes and metabolic syndrome, which includes: obesity, hyperglycemia, hypercholesterolemia, insulin resistance, and liver...
Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure
Heart failure (HF) is the most common reason for hospitalization and death among those older than 65-years, and statistic is projected to grow as our population ages. The socioecon...
A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart
Project Summary/Abstract Loss of cardiomyocytes by apoptosis and/or necrosis is a hallmark of cardiac ischemic injury, pathological remodeling, and end-stage heart failure. Althoug...
A microbiome-dependent bile acid metabolite improves type 2 diabetes.
Project Summary/Abstract The molecular mechanisms that explain the potent anti-diabetic effects of bariatric surgery remain elusive. The rapid nature of type 2 diabetes mellitus (T...
Intratumor co-delivery of DNA and RNA to relieve cancer pain
Oral cancer causes more prevalent and severe pain than any other cancer. Oral cancer patients suffer from severe, chronic, mechanically-induced pain; talking and eating are profoun...