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99,167 grants found
Showing 97,741 – 97,760 of 99,167 grants
Understanding and targeting bone marrow microenvironment in myelofibrosis
Project summary/Abstract Understanding and targeting abnormal tumor microenvironment is critically important for developing effective therapy. Primary myelofibrosis (PMF) is a form...
How do CNS fibroblasts regulate the response to neuroinflammation?
ABSTRACT Fibrosis, defined by the deposition of collagen I, is a devastating pathological event that occurs in many organs including the heart, kidney, liver and lung in response t...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophisti...
Impact of brain estrogens on cognition and brain aging in a non-human primate
SUMMARY Aromatase inhibitors (AIs) are drugs that inhibit estrogen synthesis and that are prescribed to prevent the recurrence of estrogen responsive breast cancers. However, AIs,...
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs (LAUREL Study)
SARS-CoV-2 (SARS2) infection, which leads to COVID-19, is a global pandemic. Chronic lung disease (CLD), particularly chronic obstructive pulmonary disease (COPD), has emerged as a...
Surfactant Protein C Mouse Models: A Fit For Purpose Preclinical Platform For Advancing Discovery In And Treatment Of Idiopathic Pulmonary Fibrosis
ABSTRACT Idiopathic Pulmonary fibrosis (IPF) is a devastating interstitial lung disease (ILD) of older adults characterized by disruption of distal lung architecture that ultimatel...
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Novel population-genetic methods for localizing targets of natural selection in diverse human genomes
PROJECT SUMMARY. The PI's research program in population genetics focuses on the coalescent-based inference of population his- tories from whole genomes, and the determination...
Mechanisms of RNA polymerase II transcription regulation
SUMMARY/ABSTRACT Our research program combines detailed biochemical reconstitution experiments with powerful cell-based assays, with a goal of gaining fundamental mechanistic insig...
Infection Control Measures in Dialysis Facilities after COVID-19: Disparities in Adoption and Impact on Hospitalization and Mortality
PROJECT SUMMARY The COVID-19 pandemic threatens the health of patients with kidney failure because end-stage kidney disease (ESKD) is a risk factor for COVID-19 related death. Most...
Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy
Project Summary: The long-term objective of this project is to develop a novel targeted therapy for human cancers by reactivating the tumor suppression pathways. Although p53 is fr...
cryoEM Studies of Muscle
Project Summary The long term goal of this research project has been and continues to be an understanding of the molecular mechanism of muscle function. The existing project, funde...
Development of Blood Delivery Networks for Silicon Nanomembrane-Enabled Low-Volume Membrane Oxygenators
Abstract The overall goal of this project is to optimize performance and hemocompatibility of prototype blood oxygenators enabled by silicon nanomembranes. To achieve this, the pro...
Learning principles from the pyrenoid, a phase-separated organelle
PROJECT ABSTRACT Phase separation is an emerging organizing principle for intracellular biology. Processes that are now understood to exploit phase separation include storage of ge...
Development of Asymmetric Cooperative Gold Catalysis and Beyond
Cooperative catalysis or catalysis involving metal-ligand cooperation is a highly versatile approach in catalysis that have resulted in a myriad of highly efficient synthetic metho...
Multiethnic genomic epigenomic and transcriptomic fine-mapping and functional validation analysis of schizophrenia and bipolar disorder risk loci
PROJECT SUMMARY Serious mental illness (SMI) that includes schizophrenia (SCZ) and bipolar disorder (BD) are common, complex and debilitating psychiatric disorders that together af...
Mechanisms of Advanced NAFLD Disparities in Hispanics: A Multi-level Analysis
PROJECT SUMMARY/ABSTRACT Nonalcoholic fatty liver disease (NAFLD) leading to nonalcoholic steatohepatitis (NASH) is a major cause of chronic liver disease that may progress to cirr...
Base editing and prime editing for sickle cell disease
PROJECT SUMMARY Despite advances in the medical care of sickle cell disease (SCD), most patients continue to experience severe pain, poor quality of life, progressive organ deterio...
Cerebrospinal fluid derived circulating tumor DNA as a clinically relevant biomarker in medulloblastoma
PROJECT SUMMARY Medulloblastoma (MB) is among the most common malignant brain tumors in children. Despite advances in multi-modal patient care and understanding of tumor biology, o...
Identifying Protein-Protein Network Interactions between COPD Susceptibility Genes
PROJECT SUMMARY Genome-wide association studies (GWAS) of complex diseases like COPD have identified many genomic regions associated with disease, but the molecular mechanisms by w...