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99,167 grants found
Showing 97,761 – 97,780 of 99,167 grants
Investigating gene regulatory networks in immune cells of children who differ in susceptibility to malaria infection using single-cell approaches
Project Summary/Abstract Malaria kills over 400,000 people annually, underscoring the need for a highly effective malaria vaccine. A better understanding of immunity to Plasmodium...
Responses of the Program of All-Inclusive Care of the Elderly (PACE) Organizations to COVID-19 Challenges: Effects and Lessons Learned
Project Summary/Abstract. PACE (the Program of All-Inclusive Care for the Elderly) is a well-known and respected financing and care delivery model for a very challenging population...
Translating research into school-based practice via small-group, language-focused comprehension intervention
PROJECT SUMMARY The long-term goal of this research is to translate years of federally-funded basic science on comprehension processes and interventions to provide elementary-age c...
Action of Lipolytic Enzymes
PROJECT SUMMARY/ABSTRACT The overall goal of this grant in recent years has been to describe in molecular detail the mechanism of action of physiologically important human forms of...
Role of mitophagy in age-related respiratory and vascular diseases
PROJECT SUMMARY/ABSTRACT The overarching theme of my research program is to understand how innate immunity enhances age- associated cardiovascular and pulmonary diseases. As a phys...
Phase 2 Study of Theophylline for the Treatment of Psuedohypoparathyroidism
Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gsα) signaling through downregulation of the gene, GNAS.The resultant hormone a...
Alzheimer's Disease: New Trial Designs for Emerging Challenges
Project Summary/Abstract Alzheimer’s disease (AD) is characterized by heterogeneity in sex, race, APOE ε4 status, and tau. APOE ε4 status has been used to stratify AD patients in c...
Light regulated vascular development in the eye via the Hippo pathway
Light regulated vascular development in the eye via the Hippo pathway Our recent studies show that opsin-mediated light responses function as developmental timing cues for vascular...
Acoustically-driven optical-interferometric microscope for cell characterization
AbstractThe goal of this proposal to develop a first of its kind acoustically driven quantitative phase microscopy (QPM) rheology system. Mechanical forces play an important role i...
RNA Nanosystem for Posterior Eye Drug Delivery
RNA nanotechnology provides molecules that have the simplicity in design with the characteristics of DNA and can be used in therapies. However, a major problem in RNA nanotechnolog...
Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway
Project Summary/Abstract Active listening is central to auditory cognition, supporting critical functions such as stream segregation, linguistic analysis and perceptual learning. T...
Repurposing Sulfasalazine in a Two-Arm Phase Two Double-Blind Randomized Clinical Trial for the Adjunct Management of Breast Cancer-Induced Bone Pain
Abstract Cancer-induced bone pain (CIBP) is a significant health problem in the USA and the rest of the world. With the improvement of treatment options to manage cancer, a greater...
Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation
Project Abstract The overall theme of my research program is to understand the formation mechanism of chromatin structure and its role in gene regulation. We plan to address this p...
Biomaterials-based metabolic rescue of dendritic cells for vaccine design
Abstract The main goal of this proposal is to develop biomaterial-based technologies that can modulate the functions of DCs and T-cells in the draining lymph nodes in the presence...
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures
PROJECT SUMMARY Early detection of lung cancer among asymptomatic individuals is a priority for reducing mortality of the number one cancer killer worldwide. Most lung cancers are...
Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older Latinos
Latinos are the fastest growing subpopulation of older adults in the U.S.A. and have a greater prevalence of Alzheimer’s disease (AD) than non-Latino whites (1). Despite this, our...
Nociceptor neuron regulation of gastrointestinal barrier protection and host defense
PROJECT SUMMARY Nociceptor neurons are peripheral sensory neurons that densely innervate the gastrointestinal tract, detecting noxious/harmful stimuli to mediate protective neural...
Establishing smoke-free homes with families involved in child protective services: An effectiveness-implementation trial of an integrated program
Project Abstract Child exposure to secondhand smoke (SHS) is linked to multiple forms of cancer throughout the lifespan. Young children living in low-socioeconomic status household...
Mechanisms of Diabetes and Diabetic Complications in a Multi-Ethnic Population
ABSTRACTRacial and ethnic minority populations bear a disproportionate burden of diabetes and lifetime risk for diabetes-related complications in the United States, yet little is k...
Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental Illness
Genome-wide association studies have been key for identifying genetic variation associated with psychiatric disorders. Whenever these GWAS are based on large sample sizes, however,...