Browse All Grants
15,626 grants found
Showing 3,501 – 3,520 of 15,626 grants
Standardized One Health surveillance of antibiotic residues and antibiotic- and heavy metal resistance in Baltic water environments and wild birds
Antimicrobial resistance (AMR) surveillance and monitoring in the One Health context calls for interdisciplinary and multi-national, standardized approaches at the human-animal-env...
Standardized One Health surveillance of antiBiotic residues and antibiotic and heAvy metaL resisTance In BaltiC wAter environMents and wild biRds
Antimicrobial resistance (AMR) surveillance and monitoring in the One Health context calls for interdisciplinary and multi-national, standardized approaches at the human-animal-env...
Deciphering the role and regulation of lipid mediators in health and disease
Lipid mediators are derived from fatty acids and include the prostaglandins (PG) and leukotrienes (LT), which are involved in a range of physiological and pathogenic processes such...
Investigation of the neuronal ensembles and molecular mechanisms underpinning observational fear memory
Anxiety disorders are characterized by aberrant processing of fearful memories. Substantial evidence indicates that socially transmitted fear can promote anxiety disorders. However...
Ultra-multiplexed gene regulation and machine learning for next-generation cell therapy for stroke
Stroke leads to devastating long-term consequences because the brain is unable to replace lost neurons and restore tissue architecture.Therapies that successfully treat stroke inju...
Targeting the cochlear power house to treat hearing loss
Sensory hair cells and auditory neurons within the inner ear’s cochlea have been the main cellular targets for gene therapy in age-related hearing loss.However, we revealed that ot...
The allergen exposure paradox; early exposure, tolerance development and long-term effects
The overall purpose of this research proposal is to address the paradox that allergen exposure (pollen, pets) can be both a risk and a protective factor for development and long-te...
Jejunal ketogenesis as a fat sensor – a novel intestinal mechanism in glycemic control with diabetes in sight
All comorbidities to obesity, particularly type 2 diabetes (T2D) are counteracted by Roux-en-Y gastric bypass (RYGB). We use RYGB as a human model to identify mechanisms linking ob...
The burden of maternal morbidity in Sweden in 1990-2020, including for different socioeconomic groups, and its impacts on women´s future health, working life and well-being
The overall burden of maternal morbidity in Sweden or elsewhere remains largely unknown.Maternal morbidity also impacts women´s future health but research has not been comprehensiv...
The interaction between APOE, menopause, and estrogen in Alzheimer’s disease
APOE variant 4 is the most common genetic risk factor for late-onset Alzheimer’s disease (AD), and it is well known that women carrying APOE4 run a 4-fold higher risk of AD than ma...
Utforskande av nya sätt att förhindra, upptäcka och behandla metastaserande cancer inom precisionsmedicin
We aim to develop unique treatment strategies for patients with metastatic cancer, and in parallell, predictive biomarkers and companion diagnostics for future precision medicine.T...
Molecular mechanism underlying cell identity and lineage choices in mammalian early embryonic development
The first lineage choice in human embryo development extra- and embryonic cell fates.Extraembryonic trophectoderm (TE) gives rise to placental tissues while the inner cell mass (IC...
Precision diagnostics and exploration of disease mechanisms in Inborn Errors of Metabolism
Diagnostics of rare diseases is currently being transformed due to technological breakthroughs in high-throughput methodologies such as massive parallel DNA sequencing.We have buil...
Dramatic reduction of mice used for genetic manipulations employing novel technology for gene-targeting.
This proposal describes an alternative to traditional procedures for creating knockout mouse strains, developed by Prof. M. Ohtsuka (Tokai University, Japan) in 2018 and thereafter...
Understanding Mechanisms of mRNA Vaccination
Few medical innovations have saved as many lives as vaccines against infectious diseases. During the SARS-CoV-2 pandemic, the first mRNA vaccines were approved for humans.The devel...
Does acrylamide increase the risk of neurodegenerative and cardiovascular disease?
Acrylamide, a widespread food-processing contaminant, poses a major public health concern due to its high exposure level in the general population and its toxicity.While animal evi...
Charting alternative splicing dynamics and regulation in T-cells
Alternative splicing is a complex process influenced by a multitude of factors enabling cells to produce different protein variants from the same gene, thereby increasing cellular...
Multiple sclerosis, pregnancy and treatment with rituximab
Background: Multiple sclerosis (MS) predominantly affects women, and the clinical onset of MS often occurs during child-bearing age.Clinicians recommend discontinuation of disease-...
The role of disrupted gut mucosal homeostasis in cardiometabolic disease
Diet explains almost half of the cardiometabolic disease (CMD) burden. Notably, low fiber intake increases CMD risk, although fibers cannot be digested by human enzymes. Instead, f...
Activities 2024-2026 at the National Metrology Institute - Maintenance and investment in reference equipment
Purpose and goal:The aim of the activities at the National Metrology Institute (NMI) of Sweden for 2024 is to keep the same number of CMCs (Calibration and Measurement Capability)...