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15,626 grants found
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Integrating risks of severe drought and fire into management of Swedish production forests (RISK-DF)
Swedish forestry will likely experience profound, region-specific and temporally complex impacts of climatic extremes.Although these risks to wood production are well known, the cu...
A psychosocial perspective on heart failure: etiology, prognosis and labor market participation
Purpose and aims: We aim to contribute to a better understanding of the role of psychosocial factors in the etiology and prognosis of heart failure (HF) and of patterns and predict...
Molecular guidance for calcific aortic valve disease treatment and management
Calcific aortic valve disease (CAVD) is the most common valve disease for which management is limited by unpredictable disease progression into severe aortic stenosis and the lack...
Molecular mechanisms regulating the blood-brain barrier
Rapidly growing evidence show that the blood-brain barrier (BBB) is impaired in a wide range of brain diseases, including stroke, monogenic brain disorders, neurodegenerative disea...
Detailed molecular dissection of the human brain in health and disease.
The brain is the most complex organ of our body and involved in many vital body functions.We recently mapped all proteins expressed in the brain of humans, mouse and pigs and inves...
Precision strategies to eradicate metastatic cells in neuroblastoma
Tumors are heterogeneous in nature due to genetic instability and ongoing selection.Tumor recurrency often depends on outgrowth of rare, therapy resistant subclones and commonly us...
Molecular mechanisms in the genome replication of alphaviruses and flaviviruses
Alphaviruses and flaviviruses are two types of positive-sense RNA viruses.Their numerous members are often spread by mosquitoes and ticks, and they cause serious diseases in humans...
Targeted therapies and biomarkers in advanced prostate cancer
There is a need to determine critical targets in the mechanisms of prostate carcinogenesis, progression and metastasis, and to evaluate these as prognostic and predictive biomarker...
A guided behavioral activation-based self-help intervention (INVOLVERA) for people with dementia and depression supported by informal caregivers: feasibility study and superiority randomized controlle
The overall purpose is to improve access to psychological support for people with dementia and depression.We have developed INVOLVERA, a novel behavioral activation self-help inter...
A Large-Scale venture to Reduce the use of mice to perform DNA-Protein interaction assays
How genes are regulated is becoming incresingly studied, as this is the key to understand cell pathophysiology, and for the identification of therapeutic molecular targets. Protago...
Fibroblast-regulated immune surveillance in colorectal cancer
There is a large need for improved biomarkers and treatments in colorectal cancer (CRC). Immune surveillance plays a large part in the natural course and treatment sensitivity of C...
Persistent latent infection with Neoehrlichia mikurensis can lead to malignant transformation of B cells and autoimmunity
BackgroundThe tick-borne bacterium Neoehrlichia (N.) mikurensis causes fever and vascular events of the veins in patients with compromised B cell immunity. Immunocompetent individu...
Compulsive Sexual Behavior Disorder and Pedophilic Disorder-neurobiological correlates and novel treatments
Compulsive Sexual Behavior Disorder (CSBD), a new diagnosis in the ICD-11 affecting 3-6% of the population, includes intense preoccupation and loss of control of sexual behavior, r...
Sexual dimorphism in anxiety disorders: multi-node time map of maladaptive developing brain circuits.
Anxiety is a highly prevalent (30% among adults) major global health issue.Women have two times increased risk to develop anxiety compared to men, with an increased sensitivity sta...
Towards targeting the Cohesin network in Cancer therapy, utilizing its fundamental roles in DNA damage response and repair
For our long-term goal to identify new targets for cancer treatment we focus on the protein complex Cohesin, which holds the sister chromatids together until anaphase, a function e...
Right support at the right time - test of new methods to measure risk of perinatal depression
Perinatal depression (PND), i.e. depression during pregnancy and after childbirth is a common and potentially fatal condition affecting up to 20 percent of childbearing women.There...
Tumour depositis- a novel approach to improve colorectal cancer survival
Colorectal cancer is the third most common malignancy. Despite improvements in recent decades the 5-year survival is 65%. Tumour recurrence is common.Our proposal is focused on dev...
Multi-omics approach for identification of etiopathogenesis and early detection biomarkers of stomach cancer and precursor lesions
The overall aim is to utilize multi-omics approach to identify novel etiopathogenesis and early detection biomarkers for stomach cancer and its precursor lesions.To achieve this ai...
Functional consequences of Loss Of Y (LOY) in men with Alzheimer’s disease and cancer; multi-omics study
Loss of chromosome Y (LOY) is a frequent mutation in adult males, linked to an increased risk of morbidity and mortality from various age-related diseases.Many studies performed by...
Targeting epithelial-mesenchymal transition using glycosylated calcium regulators to inhibit breast cancer progression
Ca2+ is a key inorganic molecule required for a vast majority of cellular functions. Therefore, careful management of Ca2+ dynamics is essential for optimal cell function. We previ...