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Immunomodulation and tolerance as a consequence of repeated or chronic infection
Upon repeated or chronic infection, the immune system can be trained to decrease its inflammatory response.These changes enable some pathogens, such as malaria and tuberculosis to...
Deciphering the roles of microglia plasticity and diversity in brain development and disorders.
Microglia, resident immune cells of the brain, fulfil multiple and contrasting functions in the brain from its development throughout the entire lifespan under normal conditions, b...
Parents with cancer - Feasibility and efficacy of an online group-delivered intervention to improve psychological well-being and parenting function
Being a parent of dependent children while treated for cancer can result in significant practical and emotional stress, and the risk of psychological distress is high This project...
Improved diagnostics with novel imaging-based biomarkers for non-invasive liver characterization in children
Chronic liver disease is a significant and increasing health problem in children.The global prevalence of pediatric non-alcoholic fatty liver disease (NAFLD), for example, is now a...
How the Parkinson´s kinase LRRK2 regulates the endo-lysosomal and innate immune systems
Innate immunity – the ability to sense and rapidly respond to danger, requires tight control to avert self-destruction.We are interested in the mechanisms that underlie this regula...
Extensions and applications of loss in life expectancy for cancer patients
The prognosis following a diagnosis of cancer, or other diseases, is often measured using survival proportions.Recently, however, there has been an increased interest in presenting...
The placenta as a mediator of psychological stress effects on neurodevelopmental reprogramming: lessons from human in-vitro model systems
Stress-related mental illnesses like depression and anxiety are prevalent and relevant during pregnancy, affecting over 25% of women of reproductive age.According to the developmen...
Endogenous protective mechanisms and markers in cardiovascular disease
Cardiovascular disease is the leading cause of death in the world.The underlying cause is accumulation of oxidized LDL in the vessel wall resulting in inflammation and atherosclero...
Novel Nitric Oxide Signaling Modalities in Health and Disease
BackgroundThe surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continu...
Oncogenic-driven “specialization” of mRNA splicing in hematological cancers
This proposal directly investigates the mechanisms by which oncogenic stress hijacks splicing to derail gene expression in tumor cells. Splicing is a central RNA-based process deco...
IMPLEMENTING A PRIMARY CARE BEHAVIORAL HEALTH SERVICE DELIVERY MODEL FOR MENTAL HEALTH PRACTICE: A PRAGMATIC CLUSTER TRIAL (STEPPED WEDGE)
Mental health problems represent a large and growing public health concern.Primary care handles most of the patients with mental health problems, but there are many barriers to det...
Gram-positive membrane vesicles (MVs): Biogenesis, structure, pathogenicity, and the potential as a delivery platform for antimicrobials
Pneumococcal and group A streptococcal (GAS) infections are major causes of morbidity and mortality globally.Pneumococci are the major cause of milder respiratory tract infections...
The role of gut microbiota derived branched chain amino acids for sarcopenia, osteoporosis and fracture risk
Loss of bone and muscle mass with aging leads to an increased prevalence of osteoporosis and sarcopenia, resulting in falls and fractures in the elderly.Proteins constitute a large...
Delivering quality medical oxygen in Nigeria and Uganda – evaluating impact at scale
Oxygen is an essential and life-saving medicine.The COVID-19 pandemic highlighted and exacerbated an existing global oxygen crisis, with pervasive inequities in the availability of...
PRECISION PREVENTION OF CARDIOMETABOLIC DISEASE
The aim of our research is to identify novel cardiometabolic risk factors present in parts of the population and to target these new risk factors – specifically in the individuals...
Patterns of stress across the life course and their role in mental health and loneliness in later life
The purpose is to better understand how exposure to different kinds of stressors (factors that cause stress) across the life course is associated with mental health and loneliness...
Treatment of general psychopathology
Purpose and aims: There is so much comorbidity among psychiatric conditions that one can combine them into a single general psychopathology index. Although general psychopathology...
SINGLE-CELL RESOLUTION ANALYSES TO IDENTIFY CELL-SPECIFIC ESTROGEN SIGNALING PATHWAYS IN BONE
Fractures caused by bone loss are associated with suffering and increased mortality in patients and great costs for society. Estrogen protects the skeleton and prevents bone loss....
How long can labor last? Person Centred care during labor to increase safety for women and newborn
Purpose: To increase person-centred care during labor.Specifically, we want to provide updated comprehensive information on labor duration and patient safety for reduction of;unnec...
Uncovering the role of adipose tissue fibroblast heterogeneity in health and metabolic disease progression
White adipose tissue (WAT) contains a large and heterogenous population of fibroblasts.While recent data highlight that these cells are important for organ function by influencing...