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15,626 grants found
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Unravelling the mechanisms and therapeutic opportunities of mutant p53 gain-of-function mediating tumor immune evasion
p53 as a major tumor suppressor which inactivation is required for tumor development. This inspires the idea of p53 reactivation to combat cancer.The mutant p53-reactivating compou...
NOVEL STRATEGIES TO TREAT DETRIMENTAL AIRWAY INFLAMMATION
Chronic airway inflammation results in tissue damage and remodeling (fibrosis). Mechanisms regulating influx of immune cells to the airways and their activation are of major import...
The ‘Dyslipidemic insult’ – an inflammatory response to excess lipoproteins.
An excess of lipoproteins can result in their storage in inappropriate organs. This provokes the immune system and results in tissue damage and diseases, such as atherosclerosis an...
Cellular connectivity in pancreatic islets: role in type-1 diabetes
The pancreatic islet hormones glucagon and insulin (secreted by the alpha- and beta-cells) ensure that your blood sugar levels are kept at ~5mM.Normally, a fall in plasma glucose (...
Respiratory tract pathogens and host/cell interactions as targets for intervention
Haemophilus influenzae is a bacterium that can cause severe illnesses, such as pneumonia, particularly in patients with chronic obstructive pulmonary disease (COPD) and acute otiti...
CD8 T cell differentiation and activation disentangled - implications for autoimmune diseases and T cell memory
Effective CD8 T cell responses to acute infections consist of two components – 1) killing of infected host cells, and 2) the formation of long-lived CD8 T cell memory.Killing of in...
Non-coding RNAs as targets for premature vascular aging
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare disorder, caused by a de novo point mutation in the LMNA gene, leading to mis-splicing and production of a truncated lamin A p...
Role of TGFβ-induced EMT in tumor stemness and treatment-resistance
Epithelial-mesenchymal transition (EMT) generates cell fates important for cancer metastasis. Transforming growth factor β (TGFβ) is secreted by cancer cells and stimulates EMT.TGF...
Microbiome-modulating drugs in infancy and early life
Our gut microbiome is affected by many factors, including drug use.The first years of life are crucial to establish a healthy, stable gut microbiome, yet infancy is also when most...
Can a healthy Nordic diet counteract atherosclerosis, alter gut microbiota and be personalized to enhance diet response in coronary heart disease?
BackgroundDiet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exist and the mediators of possible anti-atherosclerotic effe...
Neuro-immune regulation of type 1 diabetes onset in a dynamic framework
The goal of this proposal is to understand the involvement of sympathetic nervous signaling during onset of type 1 diabetes mellitus (T1D) using an approach which gathers mechanist...
Vitality with and for Older frail People through person-centred e-support (VOPe)
The purpose of the project is to contribute to knowledge on how frail older people´s capabilities and societal resources can be used in a more efficient way to promote health and r...
Spatially resolving B and Plasma cell clonal dynamics in cancer
Despite the clinical success of immunotherapy, many cancer patients lack optimal treatment options. B cells and B cell-derived plasma cells (PC) have recently emerged as promising,...
Metabolom vid traumatisk hjärnskada - från biomarkörer och pathways till klinisk översättning (pathTBI)
Traumatic brain injury (TBI) is one of the most common neurological diseases worldwide, affecting all ages. Improved characterization and prognostic models would allow clinicians t...
Molecular detail of resolution of inflammation in Alzheimer’s disease to develop novel treatment
Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD).A novel hypothesis is that the...
Tumour Growth and Spread Models for Evaluation of Early Detection Methodologies and Hormone Therapy Effectiveness in Breast Cancer
We will develop and use novel, biologically-motivated statistical models of tumor progression to elucidate mechanisms of breast cancer progression and to predict the risk of (in pa...
Towards a genetic risk-based prevention strategy for prostate cancer death
Prostate cancer remains one of the leading causes of cancer death. A major barrier to reducing death from prostate cancer is the lack of a clear prevention strategy. PSA testing ha...
Therapy persistence states and relapse in pediatric leukemia
Pediatric Acute Lymphoblastic Leukemia (ALL) arises from lymphocyte progenitors and is known to present a hierarchy of cell differentiation, making it a suitable model disease for...
Potassium channel double drugs
Hyperexcitability diseases, such as epilepsy, pain, and cardiac arrhythmia, are all in need of better treatments.Voltage-gated ion channels are attractive targets for pharmaceutica...
A miniaturized gut for optimization of oral medicines
The majority of pharmacologically active compounds suffers from solubility- or permeability-limited absorption and are in demand of advanced drug delivery systems (ADDSs) to enable...