Browse All Grants
15,626 grants found
Showing 3,601 – 3,620 of 15,626 grants
Biofilm in urinary tract infections
Biofilm is associated with many diseases, including urinary tract infections (UTIs).Biofilm is a specialized bacterial lifestyle that contributes to the pathogenesis of disease as...
PRECISION MEDICINE TO TREAT FATTY LIVER DISEASE
Fatty liver disease (FLD) is a growing burden with hundreds of millions of people affected worldwide. FLD starts with liver fat accumulation and progresses to inflammation, fibrosi...
Antibody-based TROP-2 targeted radiopharmaceuticals for improved theranostics of metastatic solid cancers
Triple negative breast cancer (TNBC) and metastatic urothelial cancer (mUC) have poor prognoses with low survival rates.Treatment options for these metastatic solid tumors have bee...
Effective antibody function against bacterial pathogens
Antibodies are a cornerstone of human immunity against pathogens and achieve this through multiple mechanisms.However, pathogens have evolved efficient countermeasures, and many as...
Targeting new neurocircuits for appetite modulation and obesity management
Obesity is a continuously growing public health problem, and in 2016, more than 1.9 billion adults wereoverweight or obese.According to data produced by the WHO (World Health Organ...
Altered dopamine neurotransmission and repetitive behaviours in Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a heritable neuropsychiatric disorder characterized by core behavioral symptoms.Repetitive behaviors are clinically relevant but less studied; thu...
Pre study for the establishment of high purity silicon production in Sweden
Purpose and goal:Projekt KPI´s (Jan 2024 - Dec 2024): Complete energy supply assessment, including green/brown field comparison and renewable energy PPAs, by June 2024. Develop a l...
Glial regulation of synapse numbers in schizophrenia – an integrated experimental and clinical approach to identify new targets
This proposal builds on multi-disciplinary data describing abnormal synaptic pruning as a mechanism in schizophrenia (SZ).So far, increased expression of the SZ risk gene coding fo...
Delivering the promise of CRISPR-Cas precision medicine
Widespread adoption of CRISPR-Cas methods has sparked a revolution in genome engineering and precision medicine. Scientists are now able to insert, delete, rewrite, and regulate sp...
REAL AD - A realistic screening approach for early Alzheimer´s disease
For disease-modifying treatments to be successful, early diagnosis is crucial. This is especially relevant for Alzheimer´s disease (AD) with its protracted preclinical phase.Health...
Deciphering the function and therapeutic potential of bone-specific alkaline phosphatase in tissue mineralization imbalances
Pathological vascular calcification is an independent risk factor for mortality and the most common cause of death among patients with chronic kidney disease. It has much in common...
Unravelling the vulnerability of the pons to developing Diffuse Midline Glioma (DMG)
Why certain regions of the brain are vulnerable to oncogenic transformation at critical periods of development is largely unknown.This is also the case for diffuse midline glioma,...
Molecular Mechanisms Linking Obesity to Disease in Males and Females
Obesity is the most significant risk factor for most common diseases, including cardiometabolic diseases and cancer. However, there is a difference in fat distribution among obese...
Perfusion and dopamine transporter availability in parkinsonian disorders - machine-learning-based differential diagnosis using positron emission tomography
Parkinson’s disease and related disorders are the second most common neurodegenerative diseases. Parkinsonian disorders present with similar symptoms at their onset. The diagnosis,...
Precision prevention and early therapy for RA; Combining patient reported information, epidemiology, genetics and immunology
Purpose and aims: To enable prevention of RA, both by providing information for public health based prevention and for precision prevention directed towards individuals at high ris...
Neuronal circuitry dynamics is the key to understand the brain
The function of the brain, and how its diseases arise and impact brain operation, can only be understood by knowing how its neurons dynamically cooperate globally across the brain....
Identification of tumor characteristics influencing long-term risk of distant metastatic disease and endocrine treatment benefit in ER+ breast cancer
Most breast cancer patients are diagnosed with hormone-dependent (estrogen receptor-positive, ER+) breast cancer and endocrine treatment is standard of care.A unique feature of ER+...
Targeting tissue crosstalk to combat non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis (NASH) is a prevalent liver disease that affects up to 2-6% of the general population and 15-40% of obese persons.NASH is characterized by steatosis,...
All-optical Dissection of Hypothalamic and Periaqueductal Inhibitory Circuits of Female Panic Disorder
Panic disorder (PD) has 2.5 times higher prevalence in women than in men.To develop effective treatment strategies for PD, it is crucial to examine the pathophysiology of brain cir...
Intrarenal oxygen homeostasis in diabetic kidney disease
Kidney disease is a major cause for premature mortality in diabetic patients.The focus has shifted from a glomerulocentric to a predominantly tubulocentric view of mechanisms initi...