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Envelope stress and virulence responses in enterotoxigenic Escherichia coli (ETEC) in water and during infection
The pathogen enterotoxigenic E. coli (ETEC) was first described less than 50-years ago and is now recognized as a major global cause of morbidity and mortality due to diarrhea.Mole...
Mapping of human fibroblasts´ capacities to shape the macrophage pool in human tissue
The biological importance of fibroblasts is undisputed.However, in depth fibroblast characterization on protein level in situ and ex vivo, as well their functional relationship wit...
Neuron-glia interactions in the hypothalamus, and their sensitivity to psychoactive drug abuse
The brain is the most sophisticated biological system, with its functions safeguarded by the seamless interaction of its many cell types.Single-cell biology approached brain comple...
The IKKepsilon serine/threonine protein kinase in herpes simplex virus type 2 meningitis
The overarching goal of the present project is to explore the role of the serine/threonine protein kinase IKKe in HSV2 infection and to delineate the physiologic role of this prote...
Decoding epithelial differentiation in human airways towards lung disease treatments
The lung epithelium provides the first line of defense against inhaled pollutants and pathogens.Epithelial cell diversity and its spatial organization are crucial for lung homeosta...
Atypical ubiquitin chains in immunometabolism
Despite it is now known that immune cells reprogram their cellular metabolism for exerting specific immunological functions, we still lack a deep understanding of the molecular mec...
Succinate-derived microbial metabolites as a novel treatment for non-alcoholic steatohepatitis by reprogramming immunometabolism
Following the so-called obesity epidemic the incidence of non-alcoholic steatohepatitis (NASH) is steeply increasing.An improved mechanistic understanding, particularly of inter-or...
Generating CD38-modified NK cells for combination therapy with CD38-targeting antibodies in Multiple Myeloma
CD38-targeting antibodies such as Daratumumab and Isatuximab show good efficacy in patients with multiple myeloma.In this treatment, NK cell-mediated antibody-dependent cytotoxicit...
Transfer of toxins in Staphylococcus aureus
Bacteria can exchange parts of their genome, known as the mobilome.The purpose of this project is to investigate how pathogenicity islands in Staphylococcus aureus, called SaPIs, a...
Shining a Light on Picornavirus Entry
Picornaviruses are a major cause of infections in humans and animals, impacting human health, agriculture, and economics.As obligate intracellular parasites, viruses must depend on...
Personalized cellular immunotherapy focusing on patients with cervical or ovarian cancer
Every year around 1200 females are diagnosed with either ovarian or cervical cancer in Sweden. When relapse occur, the response rate to the second line of therapy is very low and n...
Effects of Advanced Trauma Life Support® Training Compared to Standard Care on Adult Trauma Patient Outcomes: A Cluster Randomised Trial
Trauma is a massive global health issue. Many training programmes have been developed to help physicians in the initial management of trauma patients.Advanced Trauma Life Support®...
Dissecting the molecular signatures underlying sex bias in clonal hematopoiesis and blood malignancies
Human cancers develop through the successive acquisition of somatic genetic mutations and clonal evolution, often over the course of many years.Clonal hematopoiesis of indeterminat...
Defining functional cellular niches in the tumor microenvironment as targets of precision medicine
The proposed study is part of our ongoing efforts to map the influence of the tumor microenvironment on malignant phenotypes with the premise that decisive treatment benefit can on...
Role of bacteria and the microbial transcriptome during airway infections in people with Cystic fibrosis
Background:Cystic fibrosis (CF) is characterized by frequent airway infections, leading to progressive lung function decline and shortened life-expectancy.Most CF patients become c...
Spårning av klonal evolution i cancer som ett verktyg för att styra behandling
Drug resistance represents a fundamental obstacle to the successful treatment of many cancer types, including that of BCP-ALL. This malignancy is a leading cause of pediatric cance...
Characterizing brain metabolism in ALS with GlucoCEST MRI: A novel radiation-free imaging technique that can contribute to improved diagnostics and precision medicine for neurodegenerative disorders
Background: Amyotrophic lateral sclerosis (ALS) is a fatal disorder with heterogeneous clinical expression.While overt morphological findings are often preceded by hypometabolism i...
Next Generation Gene Therapy - A Cell Specific Endeavour
Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adenoassociated viral (AAV) vector variants. Many of them with unique characte...
Toward new treatments for psychotic disorders: identifying key mechanisms behind synaptic loss in early disease stages in order to improve early diagnosis and prediction of disease progression
Psychotic disorders such as schizophrenia typically affects young individuals, and cause suffering and devastating loss of function that often persist throughout life, despite trea...
Harnessing proteomic vulnerabilities of disease biology to drive tailored treatment of leukemia
Although much progress has been made in the treatment of some types of acute leukemia, others are still associated with dismal prognosis in both children and adults. New therapeuti...