Browse All Grants
15,626 grants found
Showing 4,021 – 4,040 of 15,626 grants
Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease: Identification of cell type-specific vulnerability and tolerance mechanisms
α-Synuclein (α-Syn) pathology is inextricably linked to the pathogenesis of Parkinson’s disease (PD), yet we have very limited understanding why specific neuronal populations are v...
Delineating the role of HTT Cis-Variants in the pathogenesis of Huntington disease
Huntington disease (HD) is a fatal neurodegenerative disorder without disease modifying therapies.It is well known that HD is caused by an expanded CAG repeat in the huntingtin (HT...
The roles of FTO and m6A RNA methylation in alcohol use disorder
Alcohol use disorders (AUD) are a global health concern, and understanding their molecular mechanisms is crucial for targeted therapeutics. Recent genome-wide association studies (...
Seeing motion differently: evaluating a perceptual account of the emergence of autism
Recent electroencephalography (EEG) data from our group indicates that infants who later develop Autism Spectrum Disorder (ASD) symptoms have altered functional brain activation in...
Disssecting the roles of inflammatory mediators and cell death regulation in systemic lupus erythematosus: Paving the way for reliable diagnostic and prognostic tools
Impaired clearance of cellular debris is a key event in the pathogenesis of systemic lupus erythematosus (SLE), a condition characterised by multiple organ involvement, antinuclear...
Microneedle-enabled drug delivery device for long-acting treatment of women’s health-related conditions
Women’s health-related conditions such as vaginal infections or endometriosis can have a severe impact on patient´s quality of life.Standard therapies for such diseases are associa...
Dissecting cervical goblet cell and mucus regulatory dynamics for the prevention of preterm birth
Goblet cells (GCs) secrete mucus that coats and protects our mucosal surfaces from vast quantities of microorganisms.In the intestine and lungs, GC-intrinsic protection functions c...
Preclinical and clinical studies of cell therapy for patients with therapy resistant melanoma
Melanoma occurs when pigment cells, melanocytes, acquire oncogenic mutations and they start to divide uncontrollably. If the cells spread and form metastases then melanoma is poten...
Targeting Natriuretic Peptide Receptor 3 (NPR3) to improve renal function in chronic kidney disease
Chronic kidney disease (CKD) is a major medical challenge affecting globally >10% of the population. Treatment options for CKD are limited and often ineffective.We have disc...
Define how light affects development and function of the brain and sensory systems
This project aims to define how light signaling through opsin (Opn) photoreceptors affect the development and later function of the brain and sensory systems. Few studies have exam...
Targeting Epstein-Barr virus non-coding RNA drivers of cancer hallmarks
Tumor viruses cause cancer by expression of viral proteins which can serve as oncogenes or inhibitors of host tumor suppressor proteins.We have recently discovered that Epstein-Bar...
Immune mechanisms and oxidative stress underlying the interaction of Tuberculosis and Diabetes
Type 2 diabetes (DM) is a risk factor for the development of active tuberculosis (TB).We will explore immune mechanisms of M. tuberculosis control that underly TB-DM comorbidity.Ba...
Formas proportional contribution to MAX IV operations 2024-2026
MAX IV Laboratory is a national synchrotron light facility that currently offers 16 modern beamlines to academia, research institutes, industry, and government agencies. The lab we...
ClimBeEr - Climate change effects on bumbleBEes and the ERicaceous dwarf shrubs they pollinate
Using a space-for-time substitution design and a manipulative experiment, ClimBeEr assesses the impacts of climate change on bumblebee–dwarf shrubs interactions along an altitudina...
Detecting forest metabolic shifts over the past century: implications for the land carbon sink
Forests contribute strongly to terrestrial carbon (C) stocks and impact radiative forcing by C exchange with the atmosphere.Efforts to constrain forests’ responses to interacting C...
The dualization of social rights in Sweden and beyond: How the design of social policies perpetuates income inequality
Benefit dualization is one of the most pressing issues in Sweden.It is the result of inadequate design of out-of-work benefits that favor labor market insiders with generous income...
Resolving the Euro-Atlantic Temperature Conundrum of Rapid Deglaciation
Abrupt climate shifts with extreme impacts on ecosystems are a recurrent feature of Earth´s history. With the current rapid warming of our planet, crossing tipping points becomes a...
Deciphering the distal events in insulin action that regulate glucose transport and metabolic function in adipocytes
Obesity and adipocyte dysfunction are main risk factors behind insulin resistance and type 2 diabetes.However, the molecular mechanisms causing impaired adipocyte function are not...
Effects of early nutrition on brain development and cognitive/behavioral problems in children
Nutrient deficiencies still occur in pregnant women and young children in Sweden and are prevalent for some nutrients in certain risk groups.Cognitive and behavioral problems are c...
Anorexia nervosa - two major challenges: primary prevention and preventing a chronic course
We aim to prevent children from developing anorexia nervosa (AN), and to prevent development of chronic AN.We accomplish the assignments by 1) investigating neurobiological factors...