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15,626 grants found
Showing 4,041 – 4,060 of 15,626 grants
In vivo perturbation and imaging to characterise causal genes and therapeutic targets for fatty liver disease
The purpose of this project is to improve our understanding of non-alcoholic fatty liver disease (NAFLD) aetiology and identify targets for efficient and safe treatment and prevent...
Decoding and targeting treatment-resistant metastatic neuroblastoma
The childhood cancer neuroblastoma (NB) is a major challenge in pediatric oncology, and children with relapse have a very poor prognosis due to treatment resistance at metastatic s...
Neural Cell Dysfunction in Aging and Neurodegeneration
The main aim of our research is to gain cellular, molecular and functional insights and understanding of neural aging and degeneration.In this project we will use innovative techno...
Defining protective immunity within granulomas during enteric infection
Microbial pathogens claim the lives of millions of people worldwide each year, while millions more suffer from chronic infections.Increases in antibiotic resistance threaten to und...
Targeting new innate immune evasion mechanisms in acute myeloid leukemia
Acute myeloid leukemia (AML) arises from hematopoietic stem and progenitor cells and is associated with poor survival.For the disease to develop, the AML cells need to escape tumor...
Optimizing Medication Use and Treatment Decision-Making for people with Chronic Kidney Disease
One in ten Swedes suffer from Chronic Kidney Disease (CKD), a high-risk condition in need of tailored pharmacological therapy.Ensuring adherence to guideline-recommended care and e...
Vaccination in eliminating human papillomavirus (HPV)-related diseases and beyond
Infection of oncogenic types of human papillomavirus (HPV) can cause six types of cancers, occurring in cervix, vulva, vagina, penis, anus and oropharynx.To date, HPV vaccination h...
Effects of Advanced Trauma Life Support® Training Compared to Standard Care on Adult Trauma Patient Outcomes: A Cluster Randomised Trial
Trauma is a massive global health issue. Many training programmes have been developed to help physicians in the initial management of trauma patients.Advanced Trauma Life Support®...
Novel biomarkers enable individualized early prediction of brain injury and neurological outcome after cardiac arrest
Each year, thousands of unconscious cardiac arrest (CA) patients are treated on Swedish intensive care units. 50% will not survive due to irreversible brain injury, causing ethical...
Precision medicine in RA via improved aetiological insights and clinical predictions
AIMSTo enable a precision medicine approach to the management of rheumatoid arthritis (RA) we aim to i) improve our understanding of aetiological heterogeneity of RA, and use that...
Towards the identification of the brain-wide activity motifs that cause the expression of instincts and emotions
Innate behaviors are essential for the survival of animals, including humans, and their maladaptive expression (e.g., uncontrolled aggression or generalized anxiety) carries a high...
Viral gastroenteritis: Models, molecules, and mechanisms
Enteric adenovirus (EAdV) types F40 and F41 constitute a leading cause of diarrhoea and diarrhoea-associated mortality in children.In 2021-2022, AdV-F41 and adeno-associated virus...
Immune mechanisms for exceptional response to checkpoint inhibition in metastatic melanoma
Background: Metastatic malignant melanoma is a deadly disease. Checkpoint inhibitors have improved treatment responses but most patients will die from their disease.We have observe...
The impact of Graves’ disease in the brain: from why to how
We have shown structural brain changes, a broad immune activation, and a high proportion of persistent mental fatigue (MF) after treatment of Graves’ disease (GD), the most common...
Liver innervation goes viral: mechanisms and functions of neurobiliary cross-talk during development
During embryonic liver development, developing nerves innervate both biliary cells and the vasculature. Biliary cells undergo tubulogenesis to form ducts, but the signals initiatin...
The role of inflammation-induced mast cells in lung diseases
My proposal aims at deciphering the biology of inflammation-induced mast cells with the purpose of determining their role in allergic asthma and lung cancer. Inflammation-induced m...
Targeting mechanisms for epigenetic gene silencing guarding proliferation and survival in multiple myeloma and infant acute lymphoblastic leukemia - Implications for biology and therapy
The main objective is to dissect a disease-specific global epigenetic pattern of clinical importance in multiple myeloma (MM) and infant acute lymphoblastic leukemia (iALL), to inc...
Ovarian aging, infertility and cancer - understanding the role of mitochondria in ovarian senescence and implications in health and disease for individualized risk prediction and treatment
Not all women are born equal.Even if the pool of ovarian follicles first formed in the ovaries is similar in size, some women will run out of eggs much faster than others, through...
The Gut Microbiota in Colorectal Cancer - from mechanistic insights to clinical applications
Colorectal cancer (CRC) is one of the major malignancies in the western world and evolves through a complex interplay between genetic and environmental factors. The gut microbiota...
Linking sensory physiology to transcriptomics to understand human chronic pain
Rapid progress in human transcriptome sequencing has provided information about the molecular expression of dorsal root ganglia neurons in the somatosensory system. However, functi...