Browse All Grants
15,626 grants found
Showing 4,081 – 4,100 of 15,626 grants
Youth psychiatric disorders and the risk of labour market marginalisation: Addressing the role of familial confounding and identifying patterns of labour force positions over time
Labour market marginalisation (LMM) remains a major public health concern, especially in young people with psychiatric disorders such as depression and attention-deficit hyperactiv...
Marine heatwaves and extreme weather: effects on exploited ecosystems and risks for fisheries
How ocean weather extremes affect food webs and the risks posed to fisheries is unknown.This lack prevents development of solutions for fishery businesses, actors and management to...
Progenitor cell location as determinant of fate, regeneration and transformation
In many stem cell niches, stem cells are tucked away in anatomically distinct locations, enabling exclusive interactions with niche signals that maintain stemness and prevent diffe...
Implementing Svensk Kolinlagring in the food system
Purpose and goal:Svensk Kolinlagring builds a system solution to limit climate change, increase soil content and fertility, preserve and create biological diversity and ecosystem s...
A longitudinal approach to characterize loss of muscle mass and function in aging humans – the importance of peripheral nerve integrity- part 2
The increasing number of older people being disabled by aging threatens the sustainability of the health systems. Thus, there is an urgent need to counteract aging-induced disablin...
In vitro models of human solid tumors for microchip-based efficacy-testing of drug- and immunotherapy
Several solid cancers have proven hard to treat, with no significant improvement in the last decades.This is partly due to a lack of accurate models for studying pathogenesis and s...
Deciphering RNA-mediated mechanisms mediating liver disease protection
Deciphering new links between genotype and phenotype of healthy and diseased cells is an intense area of investigation.The genetic regulation by RNA, termed riboregulation, is esse...
AMYCHRON – Amyloid Chronology to Understand Aβ Pathogenicity in Alzheimers disease
It is of critical importance to our understanding of Alzheimer’s disease (AD) pathology, to determine how key pathological factors including beta-amyloid (Aβ) plaque formation are...
Individualized treatment of epilepsy based on real-world risks of treatment failure and side effects
Epilepsy is treated with a large number of antiseizure medications (ASMs).However, the knowledge regarding which patient groups are more vulnerable to treatment failure and/or spec...
Reversible cell state transitions during vertebrate regeneration
The goal of this project is to reveal mechanisms underlying major cell state transitions and to understand how these mechanisms relate to vertebrate regeneration.We will primarily...
Glial regulation of synapse numbers in schizophrenia – an integrated multimodal experimental and clinical approach to identify new targets
This proposal builds on multi-disciplinary data describing abnormal synaptic pruning as a mechanism in schizophrenia (SZ).So far, increased expression of the SZ risk gene coding fo...
Interplay between human STING genotype and bacterial NADase activity in S. pyogenes infection – unraveling the molecular underpinnings of invasive infection and interindividual disease variability.
Invasive Streptococcus pyogenes infections are characterized by excessive inflammation associated with high fatality rates. However, the outcome of these infections varies consider...
Scalable Label-free electric detection of pathogens
Virus-caused infections are a leading cause of illness around the world.Rapid diagnosis of infectious diseases is critical for appropriate and timely treatment of infected patients...
A precision medicine approach to understand how epithelial alarmins drive asthma disease progression and exacerbations
Asthma involves different clinical phenotypes where underlying endotypes may be distinguished by immune responses of diseased epithelium. Bronchial epithelium is also target for re...
Perinatal Brain Injury
Perinatal brain injury related to hypoxic-ischemic encephalopathy or extreme prematurity results in neurologic and mental handicaps.Brain injury develops over an extended period af...
The liver and systemic processes in Alzheimer´s disease
Alzheimer´s disease (AD) is the most common neurodegenerative disease leading to dementia. The disorder is fatal and lacks established prevention strategies and cure.Approximately...
Development of therapeutic blocking agents and improved vaccines against cholera
Currently available vaccines against cholera have insufficient efficacy, especially for children in endemic areas. The severity of cholera diarrhea differs dramatically between ind...
Neutrophil extracellular traps as therapeutic targets in metastatic breast cancer
Cancer does not only affect the local site, but also the function of distant organs.Although tumor-induced systemic effects account for the majority of cancer-related deaths, the u...
UNDERSTANDING CARE DISCONTINUITY IN YOUNG ADULTS WITH CHRONIC CONDITIONS TO ALLOW FOR CARE PROCESS IMPROVEMENTS
Medical and surgical advances in congenital and pediatric-onset diseases have yielded increased life expectancy and frequently resulted in these conditions evolving towards a chron...
INDIVIDUALIZED CAUSAL EFFECTS OF BARIATRIC SURGERY ON CARDIOVASCULAR OUTCOMES AND MORTALITY
The association between weight, and cardiovascular disease and mortality is well established, however, the causal effect of weight-loss in midlife on these outcomes is less clear.B...