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15,626 grants found
Showing 4,161 – 4,180 of 15,626 grants
Microbiome monitoring for risk assessment in recirculating aquaculture systems
Aquaculture is a key technology for achieving food security, as it is a source of high-quality protein that can be produced locally with a reduced environmental impact.Recirculatin...
Unraveling the molecular mechanisms of choosing cocaine over healthy rewards
Animal research on addiction has a translational problem.Despite decades of research, advances in basic neuroscience have had limited impact on the treatment of addictive disorders...
Ethical Progress in the Face of Disagreement
In ethics, as in other disciplines, there is an expectation that systematic research efforts will increase our knowledge and generate compelling answers to the questions that are p...
The perinatal period - a "window of opportunity" for allergy prevention
Allergy is the most common chronic disease of the young.Tolerance to harmless foreign proteins, “allergens”, normally develops in the perinatal period (late pregnancy and infancy)...
Adaptation, testing and evaluation of an internet-based program for reducing cardiac distress in people surviving an MI before the age of fifty-five
A myocardial infarction (MI) is particularly burdensome for young people (
Beta Cell Targeted Drug Delivery in Diabetes
Curative treatments of Diabetes remain elusive.A major cause of failure in drug development, is the balance between sufficient drug exposure at the target receptor and the emergenc...
Systematic Evaluation of Drug Safety in older adults [SEDS]: federated analysis of international register data using an emulated target trial framework
Older adults have the highest risk of adverse drug events, yet they are regularly excluded from clinical trials where drug safety is evaluated.Apart from age restrictions in clinic...
Boosting CAR-T cells for improved cancer immunotherapy
Chimeric antigen receptor (CAR) T cell therapy is approved for blood cancers while for solid tumors, including glioblastoma, the therapy is faced with hurdles.These include poor CA...
How Extracellular Vesicles in the Human Tumor Microenvironment Regulate Cancer Progression
Extracellular vesicles (EVs) have been shown to convey complex messages between cells by shuttling proteins and RNA from one cell to another. I have recently developed a state-of-t...
Metabolomics-Driven Biomarker Discovery of Alzheimer’s Disease
Biomarker discovery in Alzheimer’s disease (AD), has been largely focused on proteomics. We hypothesize the existence of AD-specific markers further upstream of the most commonly u...
Metabolomics-Driven Biomarker Discovery of Alzheimer’s Disease
Biomarker discovery in Alzheimer’s disease (AD), has been largely focused on proteomics. We hypothesize the existence of AD-specific markers further upstream of the most commonly u...
Extreme weather effects on global food supply chains: modelling and managing risk to Swedish and global food security
Extreme weather creates risks of significant socio-economic loss, not only locally, but also along global food supply chains. For Sweden, with its strong reliance on food imports,...
Amide Proton Transfer and tissue microstructural MRI biomarkers in brain tumors for improved diagnosis and treatment follow up
MRI, the modality for diagnosis and prognosis of brain tumors, based primarily on gadolinium (Gd) enhancement (a marker of blood-brain-barrier disruption (BBB)), has become more an...
NUCLEIC ACID PRECISION THERAPY FOR TANDEM-REPEAT DISEASES
The research project focuses on precision medicine; therapeutic oligonucleotides (ONs).Our unique niche is to develop anti-gene ONs (A-GOs), which bind to the DNA duplex, where our...
Explore the molecular details of conjugation via Type 4 Secretion Systems in Gram-positive bacteria
The goal of this project is to determine the molecular structure and function of conjugation complexes belonging to Type IV Secretion Systems (T4SSs) from Gram-positive bacteria, w...
Infections in the risk and prognosis of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare but devastating neurodegenerative disease.There is currently no cure nor effective treatment for ALS, largely due to our limited under...
Deciphering ALK Signaling for Effective Therapeutic Targeting of ALK-Driven Neuroblastoma
This project aims to understand Anaplastic Lymphoma Kinase (ALK) and its role in normal and pathological developmental processes. ALK was first described in the 90s, as the NPM-ALK...
Resilient Ecosystems of Sweden: Promoting Sustainability through Continuous Cover Forestry and Wetland Rewetting
In recent decades, our planet has witnessed an increase in extreme weather events, including heat and cold waves, heavy precipitation, drought or storm events, with profound impact...
Building soil resilience to future drought and extreme weather by microbial management
We will investigate how microbial resistance and resilience to extreme weather can adapt to climate change, focusing on predicted drought, and its consequences for the land-atmosph...
How do T cells survive at the site of inflammation?- Metabolic mapping of tissue-resident memory T cells in rheumatic diseases
Chronic autoimmune diseases such as rheumatoid arthritis (RA) and myositis represent a clinical challenge due to inadequate treatment response and the recurrence of symptoms.During...