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PrePain: Prospective study aimed at finding risk factors for long-term pain by combining biological and registrybased data
Long-term pain is a major public health issue in Sweden and is responsible for extensive suffering and high sickness absence.Even though pain have a considerable impact on both the...
Precision Prevention of Cardiometabolic Diseases Through Personalized Nutrition Guided by Metabolite Biomarker Signatures
Many healthy diets have similar positive effects on risk factors for cardiometabolic diseases (CMD).It is yet unclear to what extent such effects are mediated by similar metabolic...
How multifunctionality in agricultural ecosystems depends on crop diversity and succession
Positioning agriculture within planetary boundaries, crop production requires redesign of cropping systems for multifunctionality, i.e., managing Ecosystem Functions (EF) for produ...
The contribution of Mountain birch forests to the conservation of boreal biodiversity associated with broadleaf dead wood.
Forestry has greatly reduced the area of older boreal broadleaf-rich forests and therefore biodiversity associated with boreal broadleaf dead wood (BDW) has deteriorated. However,...
Hematopoietic Stem Cell Ageing, Immunosenescence and Prospects for Rejuvenation
Progress in health care and general life standards has led to pronounced and continuous increases of the ageing population.This poses severe challenges to our healthcare systems an...
Spatial organization and paracrine control of exocytosis in islet cells
Pancreatic islets act as micro-organs whose coordinated output of insulin and glucagon regulates blood glucose.While islet hormones are released into islet-traversing capillaries t...
Surface engineered iron-rich biochars derived from waste biomass as simultaneous slow-release fertilizers and habitat for decomposers of organochlorine-compounds
Biochars are stable carbon-rich solids that can enhance the properties of soil and contribute to long-term carbon storage.Here we will study how multitasking biochars can be made f...
SynMix: Improving mechanistic understanding of chemical mixtures using large-scale cell profiling in an automated laboratory
There is an urgent need to develop strategies on how exposure to multiple chemicals and the combination of their effects can be assessed. The vast number of potential chemical comb...
Making the most out of synoptic sampling campaigns and large datasets: development of new statistical tools to optimize evaluation of environmental change
Environmental trends can be caused by influences of large-scale drivers, e.g. climate or airborne deposition, local-scale drivers, such as changes in land use, or a complex combina...
Mechanisms for fibre formation in melts for meat analogues
The food chain consumes substantial resources and contributes 25% of the total greenhouse gas emissions, with meat production alone contributing a staggering 14.5%.The consumption...
Unaccounted risk factors for the mobilization and transfer of antibiotic resistance genes from the environmental reservoir to human pathogens
Current strategies for antibiotic resistance stewardship are largely optimized to limit transmission of resistant bacteria, not to limit the emergence of new antibiotic resistance...
Metastasis heterogeneities provide possibilities for personalized therapy of patients with aggressive prostate cancer
Prostate cancer (PC) behavior ranges from harmless to lethal. Metastatic PC is treated by castration therapy followed by add-on therapies for castration-resistance. Therapy respons...
Long-term medication with proton pump inhibitors and risk of gastric cancer
AimsTo clarify if long-term proton pump inhibitor (PPI) medication increases risk of developing gastric cancer. BackgroundPPI-use is very common, but long-term use might cause gast...
Inflammation and depressed mood: mechanisms and circuits
We investigate how inflammation influences brain circuits that control mood and affective state.Using mouse genetics, including opto- and chemogenetics, we test the hypothesis that...
Revealing the Mechanims of Elastic Dosage Compensation
Correct balance of gene expression dosage is vital for normal cell function and homeostasis.Chromosomal copy number variation (CNV) results in imbalance of hundreds of genes in a s...
Can the soil priming effect enhance plant growth under elevated CO2 by alleviating nutrient limitation?
Forests are expected to play an important role in mitigating rises in atmospheric CO2 concentrations. However, the true magnitude of their capacity as carbon (C) sinks is a major u...
ALARM - Luftburet globalt varningssystem för persistenta mobila organiska föroreningar
Persistent anthropogenic contaminants started spreading globally through the atmosphere in the 1940s, and these legacy substances continue to pose toxic threats to humans and wildl...
Does biological mosquito control (Bacillus thuringiensis var. israelensi:s: Bti) affect terrestrial food web structure?
The microbial agent Bacillus thuringiensis var. israelensis (Bti) is used worldwide to control mosquitoes and other biting dipterans. However, its effects on non-target biodiversit...
Threatened subarctic palsa mires: a new integrated approach to map and understand permafrost degradation
In northern Fennoscandia, the sporadic permafrost zone is home to a unique wetland landscape composed of raised peat mounds with a permafrost core called palsas.As the Arctic warms...
Treat and prevent type 1 diabetes by mesenchymal stromal cells
Objective: By an immunomodulating cellular therapy with mesenchymal stromal (stem) cells (MSCs), we aim to prevent death of the insulin-producing beta-cells and maintain beta-cell...