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15,626 grants found
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Catalytic Antibiotics: Targeted protein degraders based on terpene natural products.
The pursuit of new antibiotics is one of almost unparalleled importance, seeing as the death toll for infectious diseases continues to rise.Traditional drug development based on sm...
Chasing traces of analyticity with applications to operator theory
My proposed investigation falls under the umbrella of research related to the uncertainty principle in Fourier analysis. The aim is to study the spectra, i.e.Fourier transforms, of...
Research careers in fragile contexts - The effects and potentials of doctoral education
The purpose of this research is to provide knowledge for PhD programs in North-South development aid partnerships on how to support graduates’ transitions to independent researcher...
Female phenotypic variation and intersexual mimicry as a bridge between micro- and macroevolution
Here, I will investigate the micro- and macroevolutionary dynamics of phenotypic variation and its effects on intra- and intersexual divergence and phenotypic diversification. Phen...
What triggers conformational change in proteins during the assembly of beta-sheet materials?
Some of the most fascinating materials in nature, such as spider silk, are built from proteins.The key to the extraordinary properties of silk is the hierarchical organization of t...
Understanding clonal hematopoiesis and initiation of myeloid malignancies
Clonal hematopoiesis often precedes the development of myeloid malignancies, but a majority of these individuals do not develop leukemia. Little is known of this tumor evolution.We...
Elucidating mito-cellular signaling to alleviate symptoms of mitochondrial disease
Mitochondrial diseases are a group of generally uncurable disorders with an often lethal outcome.Because mitochondria are essential for efficient energy production, the symptoms of...
Precision medicine models for sepsis-induced myocardial dysfunction
Myocardial dysfunction is one of the most severe manifestations of critically ill patients with sepsis, affecting 20-70% of this population.The absence of consensus criteria for th...
Coordination of cell shape acquisition during plant morphogenesis
Deciphering the precise mechanisms governing the formation of various cell types at specific time and space is a key challenge in developmental biology.This fundamental process und...
Think tank: Just Tech?
Purpose and goal:Just Tech?’s raison d´existence is the assertion that tech is entangled in the social and we need to create spaces for talking about and researching those entangle...
Unlocking Precision Medicine in Psychiatry: Targeting KAT III as a unique Concept for the Treatment of Immune-induced Cognitive Impairment and Psychosis.
The kynurenine pathway, generating neuroactive metabolites, plays a crucial role in mental processes. Excess of kynurenic acid (KYNA), driven by immune activation, triggers psychos...
Social health insurance in the Universal Health Coverage era: Does it impact health?
Low- and middle-income countries are adopting social health insurance as a mechanism for achieving universal health coverage.However, there is insufficient evidence on the causal l...
Integrative machine and deep learning models for predictive analysis in complex disease areas
We aim to develop high-performance, explainable machine learning (ML) and deep learning (DL) models that can accurately predict severe outcomes in patients with complex diseases, s...
Development of a targeted All-in-One Delivery Vehicle (AiDV) for delivery of gene editing Homology-Directed Repair (HDR) components to specific cells in vivo to treat inborn error of immunity
The end goal of the project is to efficiently deliver Cas9 and a cDNA of a gene to integrate the cDNA site specifically by homology-directed repair (HDR) to treat inborn errors of...
An in vitro test method to replace in vivo osteomyelitis models
Orthopaedic implants are used to replace joints and enhance patient quality of life after trauma or disease. However, implant-associated infections threaten the success of such tre...
Modifiable risk factors for late cardiovascular complications after childhood cancer
Increasing survival rates for childhood cancer have resulted in a rapidly growing population of childhood cancer survivors at high risk of developing late cardiovascular complicati...
Risk factors, mediators, and biomarkers related to development of premenopausal breast cancer
Emerging research suggests that exposures occurring during pregnancy can pose risks to a woman’s health. One example is the risk of developing breast cancer, which is increased for...
Retina-Brain Nexus: Alzheimer’s Pathogenesis and Diagnostic Approaches
Previous research has shown cellular changes and accumulations of amyloid aggregates in the retina of patients with Alzheimer’s Disease (AD), potentially explaining visual impairme...
Long term outcomes after metabolic and bariatric surgery during adolescence
Adolescents with severe obesity are at high risk of severe health complications and have a reduced life expectancy.Obesity treatment is currently developing rapidly with obesity su...
ALS as a systems biology disease: Linking bioenergetic dysfunction with cell-cell miscommunication
Motor neurons (MNs) and skeletal muscle fibers need to maintain bidirectional communication to avoid synaptic breakdown and systemic failure of motor control. However, we do not un...