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15,626 grants found
Showing 841 – 860 of 15,626 grants
A new material for bone and ligament regeneration
This project addresses unmet needs within orthopedic care, focusing specifically on non-union fractures and anterior cruciate ligament (ACL) rupture, through the development of nov...
Exosome: The Survival Key of Malaria Parasite Through Promoting Plasmodium-Anopheles Interaction
The malaria parasite´s survival depends on its life cycle in human and mosquito. Plasmodium falciparum renders human more attractive to mosquito, increasing the risk of transmissio...
Therapeutic implications of bioactive nitrogen oxides in reno-cardiovascular and metabolic disorders
Background: Cardiovascular, metabolic, and renal disorders are closely interconnected, largely shaped by our lifestyle (physical inactivity & unhealthy diet), which often lead...
Modulating the ubiquitin-proteasome system in human diseases
The removal of misfolded or otherwise damaged proteins from the intracellular environment is of critical importance for cells as these aberrant proteins can give rise to toxic prot...
Stress, reward and homeostasis. Role of the brain´s neural networks and their interplay with peripheral tissues in type 2 diabetes development
PurposeTo explore whether an altered ‘glucostat’ function of the brain is instrumental in the development (and reversal) of type 2 diabetes (T2D).To elucidate the role of neural ne...
Defining the role of hemodynamic forces in shaping cardiovascular system morphogenesis.
Cardiac contractions, which propel blood throughout the organism, are essential for vertebrate development as well as the maintenance of physiological processes throughout the orga...
Longitudinal profiling of the aging plasma proteome to identify risk and resilience profiles in neurocognitive aging
Large-scale screening of the plasma proteome offers great potential for non-invasively predicting and understanding systemic contributory factors of age-related cognitive decline a...
Host-microbial interactions in oral mucosa immunopathology
Neutrophils are crucial for oral homeostasis but are also drivers of tissue damage in periodontitis, a common oral immunopathology. The mechanisms determining a protective or detri...
Unraveling Lipoprotein Maturation and Transport Pathways in Gram-Negative Bacteria: Pioneering Targets for Innovative Antibacterial Therapies
The escalating challenge of antimicrobial resistance underscores the urgent need to identify novel targets for antibacterial drug development.Despite the vast diversity of bacteria...
Non-motor symptoms and complications in Parkinson´s disease: modeling and identification of targets for therapy
The goal of this Research Project is to study non-motor symptoms associated with Parkinson’s disease (PD) and whith complications caused by dopamine replacement therapies.Psychiatr...
Interaction between sex steroids, physical exercise and metabolism in female reproduction and health
Reproductive dysfunction is frequent in women with hyperandrogenism and obesity, like polycystic ovary syndrome (PCOS). On the other hand, hyperandrogenism can be beneficial for ph...
Restoring immune fitness through biophysical manipulations
While the identification of “cell types” often relies on well-defined surface markers or transcriptional repertoires, characterizing “cell states” proves to be a more nuanced chall...
Molecular mechanisms of TGFbeta signaling
Our aim is to elucidate molecular mechanisms involved in TGFb signaling in breast cancer.TGFb has both tumor suppressor (inhibits growth and induces apoptosis) and tumor promoting...
Rational design of copper electrocatalysts with tailored distribution of facets for the production of fuels (ElectroFuel).
Copper is an active catalyst for the electrochemical hydrogenation of carbon-containing molecules to produce liquid fuels. Copper can convert carbon dioxide (CO2), a greenhouse gas...
On-surface synthesis of graphene nanoribbons on non-metals studied by large-scale computational modeling
The project will predict synthesis routes of graphene nanoribbons (GNRs) on non-metal surfaces, crucial for advancing semiconductor applications.GNRs, distinguished by tailored sem...
Post-fire recruitment, microbial communities and ecosystem shifts in the Boreal forest
An increasing number of extreme boreal wildfires are leading to greater carbon (C) emissions, affecting the Earth’s climate. Post-fire recruitment of tree seedlings is key for sust...
Noggrann Analys av de Molekylära Mekanismer som Sker vid Svar på Syrebrist
Low oxygen (O2) conditions profoundly affect animals’ behavior and physiology, and underlie the pathogenesis of various human disorders. However, the fundamental mechanisms underly...
Advancing the theory of Progressive Nitrogen Limitation in boreal forests: consequences for the global carbon cycle
Boreal forest growth has increased over the past century; however, it remains uncertain whether growth will continue to increase.It is hypothesized that higher CO2 may cause nitrog...
Unravelling resistance evolution using liquid biopsies
A major challenge in medicine, especially cancer treatment is the emergence of resistance to therapy.Blood-based, or liquid, biopsies present an unprecedented opportunity to gain n...
Obese yeasts as models for eukaryotic lipid metabolism
We aim to establish the oleaginous yeast Rhodotorula toruloides as model for eukaryotic lipid metabolism. Lipid metabolism is a vital part of metabolism in all kingdoms of life. In...