Browse All Grants
15,626 grants found
Showing 881 – 900 of 15,626 grants
Excited state catalysis in chemical synthesis
The modern world relies on chemical synthesis in order to build the pharmaceuticals, agrochemicals and materials that form the basis of modern life.The overall objective of this re...
Molecular-scale understanding of current and future food proteins behaviour during falling-film evaporation
Proteins are vital to the diet.To reduce the climate impact of foods, which generates one-third of human-caused greenhouse emissions, the transition from meat-based to alternative...
A novel paradigm in islet regulation: microRNA control of α- and β-cells during development of type 2 diabetes
Type 2 diabetes (T2D) is a global health issue, impacting countless lives worldwide.The role of microRNAs (miRNAs) in the regulation of insulin and glucagon secretion represents a...
Development of cutting-edge combination therapy using neurotrophin, anti-amyloid and galantamine therapy for Alzheimer´s disease
Alzheimmer´s disease (AD) is a complex and deadly disease.Recent clinical trials reported beneficial effects of anti-amyloid immunotherapies on cognitive decline, but the cognitiv...
A blood brain barrier permeable molecular chaperone – mechanisms against neurodegeneration and potential as transport vehicle into the CNS
Amyloid is associated with Alzheimer´s disease (AD) in which Aβ42 and tau form fibrils, and with Parkinson´s disease (PD) where α-synuclein (α-syn) aggregates into fibrils.Targetin...
Deciphering Tumor Microenvironment and Macrophage Polarization in Colorectal Peritoneal Metastasis
Colorectal cancer-associated peritoneal metastasis (PM) is a serious health concern marked by high mortality rates and recurrence despite treatment advancements.Macrophages in the...
Deciphering the splicing blueprint of human myeloid cells in non-alcoholic steatohepatitis
Non-Alcoholic Steatohepatitis (NASH) is on the verge of becoming the leading cause of liver-related morbidity and mortality in the foreseeable future.The FDA´s approval of the inau...
Registry-based research for identifying and addressing the barriers to the implementation of care in patients with heart failure
Purpose and aims. Heart failure (HF) is common and linked with poor outcome. Guideline-directed medical therapy (GDMT) improves outcome but is poorly implemented.Barriers to implem...
Leveraging Alzheimer’s disease subtypes toward novel biological insight and precision medicine
Alzheimer’s disease (AD) is characterized by the build up of pathological proteins amyloid-ꞵ and tau. These proteins can be imaged in the living human brain using positron emission...
Monoclonal antibodies and intestinal organoids for human norovirus prevention studies
The purpose of the project is to identify effective tools for prevention of human norovirus infections.To fulfill the purpose I will focus on two aims: isolation and characterizati...
Microplastic- and Nanoplastic Particles as Carrier of Urban Stormwater Pollutants and their Removal Mechanisms in Alternative Sorption Materials
The aim of this research project is to determine the processes involved in the transport of metals and organic pollutants on the surfaces of micro- and nanoplastic particles (MNPs)...
Polaritonic Chemistry: Vibrational strong coupling in solution
Light is widely used in chemistry today as a classic probe and tool for initiating processes.By confining light to small volumes, the quantized light field can influence molecular...
Optimising biodiversity and carbon recovery in neotropical forests
There is an urgent need to understand and optimise the recovery of biodiversity and carbon stocks in natural ecosystems.In this project, I will work with leading scientists, a post...
The yin and yang of alternative splicing and short linear motif-based interactions
Short Linear Motifs (SLiMs) are compact modules that provide a spatially efficient solution to encode dynamic, conditional and specific protein interactions. SLiMs control key cell...
Protein-based supermaterials; the plastics in the future sustainable world
We have observed an astonishing phenomenon related to protein plastics.When foams of these materials are exposed to very harsh conditions (150 °C in air for a month), they not only...
Machine Learning Physics-based Chemical Models
Purpose: atomistic models of chemical and biological systems are either computationally expensive or not accurate enough to make reliable predictions. In addition, systematic error...
Mechanism of speciation: sperm development is controlled by rapidly evolving piRNAs
Sperm development—central to male reproductive health—is an intricate programmed process of germ cell development.Male germ cells express a uniquely broad repertoire of transcripts...
Symmetry-protected electron states in ring-like quantum dots
The purpose of this research proposal is to investigate predictions on significantly enhanced lifetimes of electron states in nanostructures with rotational symmetry and engineered...
Truly multifunctional composites materials
Coupling electrochemistry and mechanics is the starting point of this project.Carbon fibre can electrochemically insert alkali ions like lithium, and can together with a counter el...
Revisiting ribosomal catalysis
Bacterial protein synthesis is the major target of antibiotics but key requirements for the catalytic steps, peptide bond formation and release, are unclear. Both steps occur at an...