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15,626 grants found
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Powerful knowledge in national tests in social studies subjects
The aim of this project is to investigate views of knowledge in national tests in civics, geography, history, and religion.In an era of post-truth and alternative facts, a fundamen...
TIPPING POINTS IN LIPID-PROTEIN CO-ASSEMBLY
α-synuclein is an intrinsically disordered protein implicated in synaptic vesicle trafficking.Accumulation of α-synuclein in the form of amyloid deposits coincides with the loss of...
Tracking terrestrialisation: Revealing the hidden origins of animal life on land
After billions of years confined to the oceans, the emergence of life onto the continents ranks among the most pivotal milestones in the history of our planet. Despite its signific...
Elucidating mechanisms of chronic airway disease; a life-course approach
Lung development starts in utero and continues during childhood, and can be altered by several host and environmental factors during the life-course.A range of lung function trajec...
Cancer drug-induceed gastrointestinal toxicity: Pathogenesis and future management
This project is dedicated to investigate mechanisms underlying cancer drug-induced mucositis (CIM) and to identify targeted therapies for CIM.We aim to gain a in-depth molecular un...
Combined molecular and mechanistic methods for early detection and individual prevention of pressure ulcer formation in vulnerable patients
This project aims to develop a novel method for identifying early tissue damage related to pressure ulcer (PU) development in vulnerable patients by measuring biomarkers of inflamm...
Molecular dissection of nutrition-induced ribosome frameshifts, from cancer to aging.
We have recently discovered a novel mechanism by which, in response to low nutrient conditions, most ribosomes experience a -1 ribosome frameshift. This process affects most genes...
Neutrophil Immunomodulation in Oral Squamous Cell Carcinoma: A focus on Tumor-Draining Lymph Nodes
Background: Despite aggressive surgery coupled with radiation/chemoradiation, the 5-year overall survival rate of oral squamous cell carcinoma (OSCC) has stagnated at 50% for decad...
Comparative genomics decoding of virus – host interactions
The purpose of this research is to generate new knowledge about virus-host interactions and evolution by investigating the endogenous retrovirus (ERV) record.Retroviruses convert t...
Neurotrophic Mechanisms in the Adult Nervous System: A Novel Molecular Pathway Regulating Reward and Addiction
The molecular mechanisms underlying the structural and functional adaptations in neuronal circuits involved in reward and drug addiction are incompletely understood.The main goal o...
ENTITLED: Elucidating the iNequaliTy gaps in burdens and access to mental health and substance use services in Sweden using IntersecTional and impLementation rEsearch Designs
ENTITLED examines the unequal distribution of common mental disorders (CMD) and substance use disorder (SUD) burdens and unmet needs of individuals requiring mental health and subs...
Vaccine-induced immunity and innovative epidemiological surveillance of respiratory infections in older adults
This project aims to improve surveillance of respiratory infections and optimize vaccine protection against respiratory infections to reduce disease burden among older adults.Objec...
Towards personalized risk prediction of cardiovascular disease
Aim: The aim is to develop improved screening strategies to cost-effectively identify at-risk individuals before they suffer ischemic heart disease (IHD).Work-plan: We use comprehe...
Targeting MYC and Metabolism in Childhood Neuroblastoma for Precision Medicine
Childhood neuroblastoma develops in the peripherical nervous system.Building on our previous work we will i) explore the antioxidant enzyme PRDX6 as target for tailored medicine f...
National increase and local variations in ADHD diagnoses - A mixed-methods study of school contexts
ADHD has increased more in Sweden than in almost any other country and now constitutes the single most common psychiatric disorder among children.Rates of ADHD also vary greatly wi...
What is good in higher education? An empirical ethics study of relational pedagogy
In the landscape of contemporary higher education, understood to have a pervasive culture of measurement, relational pedagogy emerges as a critical discourse challenging the observ...
From macroclimate to microclimate: Plant-soil microbial interactions and ecosystem carbon cycling under global change
Destabilized carbon (C) fluxes, caused by climate change, may shift forest ecosystems from C sinks to C sources.While we know that forest C cycling is largely driven by the activit...
SmellWell: Uncovering the overlooked link between farm animal olfaction and positive emotions
Olfaction and wellbeing are strongly linked in humans, and odours may be used to improve mental health.In [SmellWell], I will bring together the science of neurobiology and etholog...
FATTY ACID HOMEOSTASIS IN C. ELEGANS AND MAMMALS: PAQR-2/ADIPOR, HYPOXIA AND OTHER PATHWAYS
Fatty acids come in a variety of lengths and unsaturation and serve in energy storage, as structural components of membranes and as precursors of signaling molecules. Given their c...
Novel therapeutics for bone growth disorders targeting the growth plate
PURPOSE AND AIM: Abnormal bone growth is a very common problem.Many children with chronic diseases have impaired bone growth, others have leg length differences, or in rare cases e...