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15,626 grants found
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Infants and leukemia: understanding the mechanisms behind leukemogenesis in early life
Acute leukemia in infancy, i.e. children aged 0-12 months, is characterized by KMT2A-gene rearrangements (KMT2A-r), and a very poor outcome. The biological reason for this poor out...
Mechanistic studies on the effects of BTK inhibitors on tumor cells and micro-environment in chronic lymphocytic leukemia
The signaling cascade that triggers the B cell mediated immune-response upon antigen binding to the B cell receptor is critically dependent on Bruton’s tyrosine kinase (BTK). The B...
Data-driven precision medicine for improved antibiotic stewardship and infection control
Objective: To enhance infection control and antibiotic stewardship through data-driven precision medicine, utilizing advanced data science and machine learning for individualized r...
Understanding and preventing aging of the human heart
Diseases of the heart muscle and valves remain leading causes of death and disability globally, but their etiological spectrum has changed over time towards predominance of aging-r...
The gut-brain axis in the perinatal period: nausea, anxiety and depression
Pregnancy and the perinatal period present metabolic, immune and hormonal challenges to the body. Neurological symptoms are also common in this period, including nausea, the "...
Dissecting human ILC development and differentiation at the clonal level
Innate lymphoid cells (ILC), including NK cells, ILC1, ILC2, and ILC3, are involved in lymphoid tissue-development, infections, cancer, inflammation and tissue-repair. We have rece...
Pathways to adverse health development and increased healthcare consumption in patients with autism spectrum disorders – the role of individual factors and pharmacological treatment
The number of people diagnosed with autism spectrum disorder (ASD) in childhood or adulthood has strongly increased over the past decades.While research demonstrates that people wi...
Evaluating the compatibility of adaptive immunity and complex tissue regeneration
It remains an open question why select animals have the ability to regenerate complex multi-tissue structures (e.g., limbs). A longstanding theory in the field of regenerative biol...
Biomarkers to reform approaches to therapy-induced neurotoxicity (BRAIN), a substudy in the ALLTogether1 leukemia protocol
New treatments and international collaboration have led to survival rates >90% for pediatric acute lymphoblastic leukemia (ALL), but treatment-related toxicity is a problem....
Improving long-term outcomes of patients with severe mental disorder and comorbid cannabis use disorder
Cannabis use is increasing worldwide and also certain European countries plan to legalize or decriminalize cannabis. This will further increase use rates and also result into highe...
Spatio-molecular and functional interrogation of serotonin subsystems
Dysfunction of complex neural circuits is implicated in neuropsychiatric disorders such as depression. The serotonin system has long been linked to the etiology of depression, as w...
Transforming an innate structural fold into a drug targeting TLR-driven systemic inflammation
Excessive activation of Toll-like receptors (TLRs) due to unresolved infection and inflammation leads to destructive diseases, such as sepsis.Current treatments based on antibiotic...
Novel cancer chemotherapies targeting tumor-specific loss of genetic variation
The purpose of this project is to identify genetic variants that alone or in combination with hallmark chromosome level events during cancer development create drug-targetable vuln...
SUM-Safe: Scaling Up Midwife-led safer birth bundle of care through Quality Improvement in Ethiopia: a stepped wedge cluster randomized controlled trial study
The purpose of this proposal is to increase the level of evidence-based practices and increase the capacity for midwives to lead Quality Improvement (QI) initiatives in maternal an...
The Göteborg2 study; A prospective randomized, population-based prostate cancer screening study with PSA followed by MRI of the prostate
The aim of this project is to develop novel and improved screening algorithms for prostate cancer (PC). The project is motivated by two reasons. First, PC is the most common cause...
Complications during pregnancy and birth and offspring risk for schizophrenia and other psychoses: Untangling Causality and Genetic Influences.
Schizophrenia and related psychoses are associated with obstetric complications but whether these associations are causal is yet to be explored.This study investigates the relation...
Improving prediction and prognosis of multiple sclerosis; algorithmic approaches and biomarkers
Multiple Sclerosis (MS), a complex autoimmune disorder affecting mainly young adults, with a higher prevalence in women.Its diverse symptoms and inherent progression complexity hin...
Population-based studies of health risks associated with breast implants (BRISK)
Around 4% of middle-aged women have breast implants, the large majority for cosmetic reasons.There are rising concerns for adverse health effects of breast implants, yet comprehens...
Hur fungerar reglering av icke-specifika membranproteiner?
Many molecular programs in our body execute differently from binary on/off sensing (i.e. being dependent solely on the presence or absence of a single factor) but instead rely on i...
Federated Reinforcement Learning (FedRL): Algorithms and Theoretical Foundations
Recent advancements in single-agent reinforcement learning (RL) have set the stage for significant AI innovations. However, when it comes to systems with multiple agents, RL faces...