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15,626 grants found
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Targeting the c-MYC oncoprotein with stapled-peptides for cancer therapeutics
The oncoprotein c-MYC is a well-established target for anti-cancer therapeutics.However, it has been extremely challenging to develop a clinically viable drug against c-MYC because...
Gene engineering of the tumor microenvironment to induce sustained anti-tumor immunity in cancer patients
The aim of this project is to develop a new treatment for cancer based on a gene engineering vaccine.The field of gene engineering vaccines gained attention during the pandemic as...
Advancing Uterus Transplantation and Bioengineered Uterus: Current and Future Approaches to Treating Uterine Factor Infertility
BACKGROUND Infertility affects 15% of couples. By introduction of IVF and ICSI in 1980-90s most types of infertility could be treated. Absolute uterine factor infertility (AUFI) re...
The role of pallido-striatal neurons in sensory processing under parkinsonian and DBS conditions
The external Globus Pallidus (GPe) is a central part of the Basal Ganglia (BG), a group of subcortical nuclei supporting motor control and involved in movement disorders such as Pa...
The PEPP (PreEclampsia Postpartum Prevention) Trial: A postpartum intervention to improve cardiometabolic health in women with preeclampsia - a multi-centre randomised controlled trial
Preeclampsia (PE), a severe hypertensive disorder of pregnancy, is strongly associated with complications in subsequent pregnancy and early-onset cardiovascular diseases (CVD).Wome...
Modulating host macrophage functions to control latent tuberculosis - using helminth coinfection in high-endemic areas as a model
This project focuses on how chronic helminthic worm infections impair immune control of human tuberculosis (TB), and how current treatment strategies could be optimized to shorten...
Biofabrication of a Cartilage Microphysiological System (OA-on-a-CHIP) for Osteoarthritis Disease Modelling and Therapeutic Testing
Osteoarthritis (OA) is a chronic, progressive, degeneration of articular cartilage (AC) which affects >500 million people worldwide. The majority of research into OA uses no...
Biological principles of schizophrenia: adolescent cell type-specification and synaptic pruning in prefrontal cortex
PURPOSE AND AIMSSchizophrenia (SCZ) is a genetically complex and poorly managed disorder with a complicated pathology that generally manifests in early adulthood.With few exception...
People Who Aren’t Really There: ‘Non-persons’ as a field of scholarly inquiry
Recent years have seen previously largely unnoticed groups—frontline health workers, workers along global supply chains, victims of sexual abuse, people who subscribe to outlandish...
Brainstem circuit ensembles for movement flexibility
Movement is the shared language of behavior across the animal kingdom, orchestrated by dedicated circuits throughout the central nervous system.To survive, animals must move with a...
Walking while Talking: A Cross-Linguistic Study of the Moving Speech Situation among Mobile Foragers
This project investigates human language in the very environment in which it has evolved, is acquired, and veryfrequently is used: while walking.Yet, moving communication contexts...
Developing GRAFTing to enABLE hybridisation of new species for agriculture and forestry
Modern agriculture depends on developing new crops and techniques to enhance yields, disease resistance and tolerance to drought and extreme temperatures.One such innovation has be...
Unveiling the Molecular Secrets of Reproductive Mood Disorders: a Multi-Omics Approach Project
Reproductive mood disorders (RMDs), including premenstrual disorder and postpartum depression, have a significant impact on women and their families, contributing to the well-known...
Structure and Function-based Design of Vaccine Antigens and Antiviral Immunotherapies
Vaccines are critical in preventing viral diseases, and recent advances in vaccine development and delivery platforms have enhanced their reach and efficacy.Viral glycoproteins tha...
Holistic Rigorous Numerical Verification
My goal is to make rigorous numerical verification widely applicable and practically usable. Rigorous verification proves at compile-time that a program computes for all valid inpu...
Cryosphere-hydrosphere-lithosphere interactions under changing climate in Arctic
The rapid climate warming in Arctic leads to formation of extensive offshore groundwater reserves through submarine permafrost and subglacial melt water drainage.There is increasin...
CoEvoLens: Disentangling the microevolutionary mechanisms of coevolution
Coevolution, characterized by reciprocal trait changes driven by mutual selection between interacting species, is pivotal in shaping biodiversity.However, understanding the genetic...
Reading a Artistic Practice: a Nordic Reading Laboratory
The Artistic Reading Workshop will bring together writers, teachers and researchers in literary composition to explore the concept “artistic reading”, based on literary practices.T...
Deciphering the developing immune system through antibody profiling and integrative omics
Novel molecular methods offer to shine new light on immune system development.These technical advances can now aid in resolving how early-life exposures to microbes and environment...
Mapping Trade-Off Dynamics in Yeast: A Multi-Omics Pareto Approach
Understanding trade-offs between microbial traits is crucial as they reveal how organisms balance competing objectives, such as growth and survival. Trade-offs shape evolutionary a...