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15,626 grants found
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CIRCUITRY REPAIR IN PARKINSON’S DISEASE: FROM STEM CELL REPLACEMENT TO AXONAL TARGETING USING STEM CELL MODELS
Neurodegenerative diseases are debilitating conditions that result in dysfunction and loss of nerve cells.The brain has a very limited capacity for self-repair, and there is an unm...
The Evolution of Minds: 325 million years of intelligence studied with neuroscience, cognitive zoology and palaeontology
Cognition separates animals from all other forms of life. Although cognition is the essence of our existence, we know little about it.Compared to other aspects of biology, we know...
Epigenetics of the lung-brain axis in Multiple Sclerosis: unravelling the impact of smoking on disease pathogenesis and progression
Multiple Sclerosis (MS), inflammatory disease of the central nervous system, is a leading cause of unpredictable lifelong disability in young adults, with a yet unexplained rise in...
Genetic drivers, telomere maintenance and metabolism in development of high-risk pheochromocytoma and abdominal paraganglioma
Pheochromocytoma (PCC) and abdominal paraganglioma (aPGL) originate from the adrenal medulla or sympathetic paraganglia.Here we aim to further clarify key events of underlying driv...
Dissecting the role of IL8 in cancer using a new IL8-humanized mouse model
IL8 is a pleiotropic chemokine with important roles in e.g. neutrophil chemotaxis, tumor growth, and angiogenesis. In addition, IL8 has also been associated to resistance against c...
Defining the local tissue niche for resident memory B cells in allergic disease
Allergen (Ag)-specific IgE causes many of the symptoms we associate with allergy and asthma.Despite the fact that we use ag-specific IgE as a diagnostic tool for allergic disease,...
Boosting the therapeutic potential of engineered T cells through revamped synthetic circuits
Despite showing remarkable clinical responses in certain late-stage hematological malignancies, chimeric antigen receptor (CAR) T cell-based therapy have failed to demonstrate comp...
ISG15 at the interface of innate immune response and metabolic pathways during respiratory viral infections
In spite of significant advances in virology, emerging and re-emerging respiratory viral infections caused by human pathogenic coronaviruses and Influenza virus remain a major thre...
Geopolitics at the margins - Exploring emergent political orders across the Red Sea
The Red Sea Region is at the centre of new geopolitical intrigue: from significant investments in infrastructure projects to the establishment of military bases, to increased labou...
Discerning the role of the private sector in creating health system resilience: A case study in Zambia
The COVID-19 pandemic has threatened the ability of many health systems to function and continue delivering healthcare. Resilient health systems can adapt their health services in...
Quantification of emerging contaminants with liquid chromatography high resolution mass spectrometry and graph-based machine learning
Understanding the toxicity of real-world complex mixtures, and identification of the most toxic chemicals is an essential starting point for the intelligent design of water treatme...
Data-driven optimal models for kinetic dynamos
The magnetic fields permeating the universe profoundly affect the development of astrophysical systems from stellar to cosmological scales, and play key roles in transport and part...
Characteristic classes of manifold bundles and graph complexes
The importance of characteristic classes in geometry and topology can hardly be overestimated, but characteristic classes for bundles whose fibers are closed manifolds are still no...
Identifying novel targets for directed therapy against acute leukemia by uncovering the molecular details of FLT3 signaling
Acute myeloid leukemia (AML) is the second most common type of leukemia, characterized by a rapid expansion of immature blood cells of the myeloid lineage.The most commonly mutated...
Integrative digital diagnostics for therapy optimization in early breast cancer
Purpose and aimsThis project aims to develop tools for prediction of response to neoadjuvant (pre-operative) therapy (NAT) and prognostication of post-surgery risk of recurrence in...
UNCOVERING HOW TISSUE-SPECIFIC WNT SIGNALING DRIVES COLORECTAL CANCER BEHAVIOUR: A WAY TO DISTINGUISH NORMAL CELLS FROM CANCER CELLS
Wnt signaling is a conserved cell-communication pathway that induces changes in cell behavior during tissue development and homeostasis. Deregulation of this pathway causes several...
Novel Strategies to Target Glioma Stem Cells
Malignant stem-like cells are responsible for the growth and maintenance of the brain tumor glioma.While these cells have the capacity to evade standard cancer therapy and are an i...
Women´s mental health: Serotonin and steroids
Mood and anxiety disorders largely affect mental health in a profound sex- and hormone-dependent manner, not only in terms of symptoms occurrence and prevalence, but likely also re...
Lepton interactions with protons
This proposal addresses one of the open questions of the Standard Model of particle physics, namely the properties of the neutrinos.A major ingredient in most solutions to this puz...
Better than expected: a simultaneous PET/fMRI study of how prediction errors shape long-term fear reduction
Learning that once threat-predicting objects now are safe can be achieved through fear extinction.Principles of fear extinction underlie exposure therapy, often used to treat anxie...