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44,293 grants found
Showing 201 – 220 of 44,293 grants
Accelerating my career in general practice research and policy: a realist evaluation of relational continuity in UK general practice
My ambition for this award is to build my research portfolio, skills and reputation to launch me into the next stage of my career as a general practice research and policy leader....
Using immunopeptidomics and spatial genomics to determine the autoantigen, presenting cells and responding CD8 T cells in ankylosing spondylitis
Ankylosing spondylitis (AS) is a debilitating autoimmune disease affecting patients globally with limited and often costly treatment options.Diagnostic delay and higher disease act...
Diverse public perspectives in cancer screening and early diagnosis: generating evidence to support policy (the PERSPECTIVES project)
Background: Many new innovations in cancer screening and early diagnosis raise complex choices, communication challenges and ethical issues for patients and members of the public.T...
Enabling Non-invasive Image-based Prostate Cancer Detection Through Machine Reasoning
We aim to develop a transformative machine learning (ML) algorithm, inspired by human cognition, to advance image-based prostate cancer diagnosis, addressing a critical gap in curr...
Developing targeted strategies for precision breast cancer prevention
Background: Breast cancer (BC) is the leading cause of death in UK women aged 35-64. Women at increased risk are offered tamoxifen as prevention therapy, which reduces BC incidence...
Agent-based Modelling for Ebola Risk Reduction: Understanding and Mitigating the Potential for Global Transportation-fuelled Epidemics (ABMERR)
My fellowship originally proposed to simulate outbreaks of Ebola throughout western Africa; I originally wrote that "humanitarians are in urgent need of operational intell...
Aims to identify how the neuropeptide galanin regulates the physiology and adaptation of pancreatic islets under healthy and diabetic states.
The project aims to identify how the neuropeptide galanin regulates the physiology and adaptation of pancreatic islets under healthy and diabetic states.Hormones released from panc...
OFFBEAT: roles of unstudied genes in cellular quiescence and aging
Biological researchers concentrate their efforts on studying genes that are already known and function in established processes. While this focus on model genes is rewarding, we mu...
NMR imaging for the accelerated discovery of drugs and materials
Analytical methods play a vital but often hidden role in scientific research. Nuclear magnetic resonance (NMR) spectroscopy is an indispensable technique for probing the structure...
Embedded Cluster Modelling for Realistic Solid-State Systems
The combination of computer simulation with experiment is fundamental to achieving new understanding in chemistry, and to delivering advances that can address the most pressing soc...
Bcc-superalloys: Engineering Resilience to Extreme Environments
Nuclear fusion, Generation IV fission reactors and aerospace gas turbines are critical to our future energy generation and transportation. Their operation at high temperatures nece...
Non-Enzymatic Catalysis in the Microbial Cell Interior
The field of synthetic biology enables industrial chemicals that are currently derived from unsustainable fossil fuels to instead be manufactured from sustainable feedstocks by liv...
All-Optical Near-Infrared Imaging via Semiconductor Nanocrystals - Renewal
This project is developing a new technology for Near Infrared (NIR) light imaging that is ultra-compact and multi-colour. Human eyes only see 0.0035% (visible light) of the electro...
Interactions Between People Who Use Drugs and the Police: Experiences and Impacts (INTERPRET) - APP9112
There are great harms to individuals and costs to society associated with illegal drugs. In 2021, there was the highest number of drug-related deaths in England and Wales since rec...
Landscape Historical Ecology and Archaeology of Ancient Pastoral Societies in Kenya
The origin of livestock herding in eastern Africa dates to around c. 5000 BP and entailed a combination of demic migration of new populations into the region pushed southward as a...
NSFGEO-NERC: Magnetotelluric imaging and geodynamical/geochemical investigations of plume-ridge interaction in the Galapagos
Understanding how melt aggregates in our planet's deep interior, i.e. its mantle, during melting remains a critical and fundamental open question in the Earth Sciences. This h...
Apoplastic Signalling Communicates Emergency Responses
In order to survive, organisms must interpret diverse signals across all scales of biological organisation - from individual cells to tissues and the whole organism. Only by doing...
(2XPLO2D) Exploring 2D materials and their van der Waals assemblies
Research on two-dimensional (2D) materials and their van der Waals assemblies has expanded dramatically reaching beyond condensed matter physics and materials science, into such di...
Stuck in the mud: addressing the fine sediment conundrum with multiscale and interdisciplinary approaches to support global freshwater biodiversity
Environmental change is happening on a global scale.Freshwater ecosystems represent some of the most endangered habitats in the world, with declines in diversity (83% in the period...
UKRI FLF renewal: Energy Metabolism and Antibiotic Action in the Tuberculosis Pathogen
Scientific backgroundBioenergetic systems give living organisms the energy they need to live and grow. For organisms that grow with air, bioenergetic systems are composed of electr...