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44,293 grants found
Showing 241 – 260 of 44,293 grants
Tracing the origin of clonal pathogenesis
Epithelial cancers are thought to evolve through a competitive process of mutation and selection in which the serial acquisition of oncogenic mutations confers an increasing fitnes...
Reconfiguring Moiré Quantum Materials on Demand through Strain Engineering
The rise of moiré materials based on twisted layers of two-dimensional (2D) crystals constitutes arguably one of the most exciting opportunities in the manipulation of synthetic qu...
Quantum Synthesis
Quantum circuits form the basic building blocks of quantum computers and algorithms.Current quantum algorithms are created and analysed manually and in an ad-hoc manner.We want to...
Identification, recording, and reasonable adjustments for people with a learning disability and autistic people in NHS electronic clinical record systems: studies using routine data, data linkage and machine learning to improve access to, and quality of, NHS care
RESEARCH QUESTIONS- How well is learning disability and autism recorded in different electronic health records (EHRs)? What factors are associated with these conditions being unrec...
Omeprazole for Treatment of Term and preterm infants with gastro-oEsophageal Reflux (OTTER)
Research question: In preterm (
Developing and applying new autistic-led standards for social care environments: a participatory action research study of Ethical Quality Autistic-Led Support (EQUALS)
Numerous reviews have highlighted that residential social care and supported living services are currently failing autistic adults. Best practice standards often remain unmet, plac...
ANXIOMICS: Finding the mind, brain and immune pathways to anxiety
We do not know why some people experience anxiety disorders, but with twin heritability estimates of 20 – 60%, our genes play a key causal role. However, the mechanisms through whi...
Exploring the contribution of social inequality to the evolution of the Mycobacterium tuberculosis complex across five millennia
Tuberculosis (TB) is globally the top cause of death by an infectious agent but disproportionately affects those in poor countries without access to adequate nutrition.TB is today...
BiBBS ACHIEVE: Addressing Childhood Inequalities through Evidence-Based Early Interventions using Born in Bradford’s Better Start (BiBBS) birth cohort
Our vision is to conduct discovery research to better understand how to effectively intervene to create a healthier, happier, and fairer future for socially disadvantaged children....
Neurofeedback for Nociplastic Pain in Rheumatoid Arthritis (NECTAR): a Pilot Study
Rheumatoid arthritis (RA) is an autoimmune condition leading to inflammation and pain. Even after treating inflammation, RA patients experience persistent residual pain similar to...
Exploring the development of and public support for healthy and planet- friendly food marketing policies: co-designing meat marketing restrictions
Current patterns in the production and consumption of food are resulting in poor health and environmental outcomes.Since marketing influences food choices, using policies to change...
SISTAH: Understanding and Enhancing Cancer Health Equity for Black and Mixed Black ethnic minority Women through a community participatory-based approach (CBPR) and Sistah Circles/Sister Circles.
Black and mixed Black ethnic minority women in the UK are more likely to be diagnosed with breast, ovarian, and uterine cancers at later stages, when treatment is less likely to be...
Spatial Prostate Assessment and the Circulating Environment - discovering the lethal clone (SPACE-X)
Background Prostate cancer (PCa) diagnosis has advanced significantly, but we still lack certainty about who needs treatment.PCa is inherently heterogeneous, as demonstrated by my...
Understanding the pathophysiology of auto-immunity through Immune Checkpoint Blockade
Cancer immunotherapy consisting of Immune Checkpoint Blockade (ICB) has reshaped management and outcomes for many cancers, but frequently elicits autoimmune side-effects (immune-re...
Discovering and targeting the wider super-enhancer network of acute lymphoblastic leukaemia
Background B cell acute lymphoblastic leukaemia (B-ALL) is the most common childhood malignancy and despite survival being high (children, ~90%), outcome is worse for adults and th...
Understanding tumour progression using different tumour-specific factors
Background Cancer early detection presents the challenge of balancing the interception of progressive lesions before they become invasive with avoiding overdiagnosis of indolent le...
Socio-demographic inequalities of access to novel genomic testing and therapeutics in solid tumours in the UK
BACKGROUND Socio-demographic inequities are recognised as impacting patients with cancer throughout their journey from diagnosis to treatment decisions.Genomic testing for targetab...
Identifying, understanding and addressing inequalities in cancer treatment
Background. Cancer is a leading cause of mortality in the United Kingdom.Chances for survival are improved when patients receive treatment (‘treatment receipt’), with further impro...
Platform body-territory politics: gendered geographies of Santiago de Chile’s digitalising borderlands
smart urbanism
From Turing’s to force patterns, microsystems to understand mechanics in limb morphogenesis
Biomechanics