Browse All Grants
44,293 grants found
Showing 41,181 – 41,200 of 44,293 grants
Susceptibility to Chronic Pain: role of Cerebellar - Periaqueductal Gray Communication
Acute pain is a necessary sensory function that signals tissue damaging stimuli such as the heat of a fire. It is short lasting and is essential for survival, as it drives simple p...
Development and utilisation of a ubiquitin directed photoreactive probe to identify endogenous E2-RING E3 interactions
Ubiquitin is a small protein, its addition to other proteins regulates many cellular processes such as protein homeostasis and cell signalling. The addition of ubiquitin to protein...
A new voice for R&D investment
See attached document.
Endothelial glycocalyx restoration to prevent proteinuria-associated vascular damage
Cardiovascular disease is the leading cause of premature death in chronic kidney disease, and proteinuria is an independent risk factor of cardiovascular mortality. Reducing protei...
A combined experimental and numerical investigation of premixed flame-wall interaction in turbulent boundary layers
The presence of walls alters the thermo-chemical and fluid-dynamical processes associated with turbulent premixed flames.The increasing demands for light-weight combustors make fla...
UKRI trusted and connected Data and Analytics Research Environments, Phase 1
The UK Trusted and Connected Data and Analytics Research Environments, Phase 1 project involves an extensive scoping phase ("Design and Dialogue") which will invo...
Implications of the Cardiac Hepcidin/Ferroportin axis for the Management of Iron Deficiency in Heart Failure
Iron is essential for life. It is required not only for the synthesis of haemoglobin, which carries oxygen around our bodies, but also for the function of the enzymes that generate...
Hhat inhibition as a novel approach for selective cancer treatment
Being the first or second most common cause of premature death in over 100 countries, cancer imposes a major burden on modern societies worldwide.Inhibition of the Hedgehog pathway...
Role of tetrahydrobiopterin in the pathophysiology and long term complications of preeclampsia: a randomised controlled trial in mothers and offspring (Dr Annabelle Frost)
Preeclampsia complicates 3-8% of pregnancies and is a major cause of maternal and fetal morbidity and mortality.The pathogenesis is multifactorial but endothelial dysfunction is ce...
Development of versatile fluorescence probes for detection and imaging of heme oxygenase 1 (HO-1) activity in haemorrhage for clinical diagnostics
Heme oxygenase-1 (HO-1) is a critical enzyme for vascular health and disease and a marker of hemorrhage in ruptured coronary plaques and hemorrhagic stroke. Yet it lacks a good det...
UK participation in EU Joint Action - Sharing Health Data
- Execute UK assigned tasks and responsibilities within the Joint action To a high standard, Establishing the UK as a valued and trusted partner. - Gather a body of evidence of NHS...
Dostarlimab for previously treated advanced or recurrent endometrial cancer with high microsatellite instability or mismatch repair deficiency [ID3802]
To appraise the clinical and cost effectiveness of dostarlimab within its marketing authorisation for previously treated advanced or recurrent endometrial cancer with high microsat...
The Role of Visual Arts Organisations in the British Black Arts Movement in the Midlands
The birth of the British Black Arts Movement (BAM) in the early 1980s was responsible for a paradigm shift in UK art history, bringing to the fore the issues, concerns, practices a...
Emergency oxygen response for COVID-19
The O2 Taskforce is coordinating access to emergency oxygen for COVID-19 patients in LMICs. Since the start of the pandemic, affordable, sustainable access to oxygen has been a gro...
Atezolizumab for untreated PD-L1 positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable (CDF review TA492) (ID3777)
To appraise the clinical and cost effectiveness of atezolizumab within its marketing authorisation for treating locally advanced or metastatic urothelial carcinoma in people who ar...
Asymmetric dimethylarginine (ADMA) signalling via the calcium sensing receptor in cardiometabolic disease
Asymmetric dimethylarginine (ADMA) is an established risk factor for cardiovascular disease and is elevated in individuals with hypertension, coronary heart disease and obesity.ADM...
Investigating protein synthesis during dormancy in Pseudomonas aeruginosa
Much of our understanding of bacteria, and the biological processes which sustain them, comes from the study of rapidly growing populations in nutrient-rich conditions. However, in...
The role and control of mast cell responses in intestinal helminth infection
Parasitic worms can infect people for many years, despite the efforts of the immune system to eject them. They achieve this through the release of molecules which suppress parts of...
Identification and characterization of new genes required for Type VI Secretion System mediated anti-bacterial activity
Bacteria typically exist in mixed communities with other microorganisms and therefore, need to compete with rival microorganisms for resources and space.The Type VI secretion syste...
Computational framework for modelling immune cell migration in tissue repair and the origins of cancer
I am interested in how immune cells move through tissue responding to signals from injury or tumours.I will use data from multiple biological systems and Bayesian statistics to mat...