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Cancer Grand Challenges: Operations Management Application
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Greenhouse gas removal with UK agriculture via enhanced rock weathering
Meeting the UK's obligations for net-zero carbon emissions by 2050 requires capturing and storing residual emissions of approximately 130 million tonnes of CO2e (CO2 equivalen...
Overcoming the curse of dimensionality in dynamic programming by tensor decompositions
Almost 60-years ago Richard Bellman coined the expression ``curse of dimensionality'' when referring to the overwhelming computational complexity associated with the solu...
New Enzymatic Virulence Factors In Phytophthora Infestans
Abstracts are not currently available in GtR for all funded research.This is normally because the abstract was not required at the time of proposal submission, but may be because i...
How does the immunomodulatory parasitic worm product ES-62 rewire bone marrow cells to increase healthspan and lifespan in obesity-accelerated ageing?
Around a quarter of the global human population is infected with parasitic worms. Although undoubtedly a public health problem, increasingly there is acceptance that these traditio...
Does the parasitic worm product ES-62 resolve aberrant chronic inflammation by sensing and normalising the gut microbiome and intestinal integrity?
Abstracts are not currently available in GtR for all funded research.This is normally because the abstract was not required at the time of proposal submission, but may be because i...
Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage
Brain haemorrhages are the most severe type of stroke, and patients are often left with disabilities due to brain damage. We currently do not know much about how the brain tissue a...
Greenhouse Gas Removal by Accelerated Peat Formation
Peatlands store more carbon than any other terrestrial ecosystem, both in the UK and globally. As a result of human disturbance they are rapidly losing this carbon to the atmospher...
Translation validation for weak memory models
We intend to develop tools to check whether mappings from high-level languages to lower-level ones are sound with respect to weak memory models - examples include: compiler mapping...
CATH-FunVar - Predicting Viral and Human Variants Affecting COVID-19 Susceptibility and Severity and Repurposing Therapeutics
SARS-CoV-2 has caused a pandemic resulting in millions of deaths worldwide and significant social and economic disruption. Although vaccine trials have been encouraging vaccines mu...
Niraparib for maintenance treatment of platinum-sensitive ovarian cancer after second response to chemotherapy (CDF review of TA528)
To appraise the clinical and cost effectiveness of niraparib within its marketing authorisation as maintenance treatment of recurrent platinum-sensitive ovarian fallopian tube and...
Plight of Pelagic Primary Producers in a Changing Marine Environment
The P4 fellowship will test the impact of past climate extremes on marine ecosystems using coccolithophores, a group of marine primary producers that experienced first order effect...
Role of the oral microbiome & mucosal immunity in COVID-19 disease: diagnostic/prognostic utility in South Asian populations
COVID-19 primarily infects lungs, mouth and nose, which are all mucosae (linings of body cavities) and all part of the mucosal immune system which protects mucosal surfaces and is...
CARDINNATE: Variation in innate immune activation and cardiovascular disease risk as drivers of COVID19 outcome in South Asians in UK and India
While COVID-19 causes minor illness in most people, some individuals develop more severe disease requiring admission to hospital including intensive care. People of South Asian her...
CoV-Ind-UK: Prospective investigation of the determinants for COVID-19 outcomes amongst South Asians in India and the United Kingdom.
Results of studies from India and the UK show that South Asian people are at high risk for risk COVID-19, or to being infected with the SARS-CoV2 virus which causes this illness. T...
Interfacing Ultracold Polar Molecules with Rydberg atoms: A Hybrid Platform for Quantum Science
The predictions of quantum mechanics, the theory that governs all matter at a microscopic level, are often fascinating and sometimes mystifying. At the heart of this theory are two...
Chin Tuck Against Resistance with Feedback: Swallowing Rehabilitation in Frail Older People (CTAR-SwiFt) - A feasibility study
Introduction: It is well-known that frail patients who are admitted to hospital can have particular difficulty in swallowing (pharyngeal dysphagia).Therapeutic rehabilitation exerc...
Search for axion-like particle produciton in kaon decays at CERN-NA62 experiment
It is proposed to perform the first search for production of a short-lived axion-like particle (ALP) in charged-kaon decays (K+ --> pi+a), which decaying promptly into a di-phot...
Development of Target Product Profiles for Snake Antivenom Products
Antivenoms are bespoke biologicals that have been the mainstay of snakebite treatment for 125-years. Requirements for production, safety and efficacy vary across regulatory environ...
Can we develop a "cognitive vaccine" for intrusive memories of traumatic events from working in the COVID-19 pandemic? A novel and brief intervention to support ICU staff
Intensive care unit (ICU) staff face repeated exposure to traumatic work-related events and have reported high levels of posttraumatic symptoms during the pandemic. Novel, scalable...