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44,293 grants found
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Understanding how mitochondria send out danger signals
Inflammation
Certifying China: The Rise and Limits of Transnational Sustainability Governance in Emerging Economies
Sustainability
Rethinking Advocacy Journalism in Exile: A Comparative Study of Arab Diasporic Media in Transnational Hybrid Media Systems
media panarabo
Terrorism Criminalization. Swiss criminal law study with comparative law perspectives (Germany, France and United Kingdom)
Droit pénal du terrorisme
Out at sea, out of mind: Could improved fishing vessel safety standards help mitigate against labour abuse and related fisheries crime?'
Forced labour slavery
Developing novel targeted immunotherapy for infant and childhood MLL-rearranged acute lymphoblastic leukaemia (co-funded by Children with Cancer UK)
Background: MLL-rearranged infant acute lymphoblastic leukaemia (MLLr-iALL) has a very poor prognosis (40% cure rates), highlighting the need for novel treatment strategies.Chimaer...
Investigating cutaneous T-cell trafficking during treatment with immune checkpoint blockade
Background Antibodies that block the immune checkpoint response proteins PD1 and CTLA4 have revolutionised the treatment of metastatic melanoma. There is substantial clinical heter...
Evaluating ethnic differences in blood markers of cancer in primary care
Background Ethnic minority groups in the UK have poorer cancer outcomes than British White groups. Improving cancer detection strategies for this population may boost UK cancer out...
Implementation, delivery and perceived effectiveness of a peer intervention for smoke-free living and health improvement for people in custody
Background: Smokefree legislation was introduced in all Scottish prisons from 30th November 2018.Although initial implementation appears successful, building on the new legislation...
ACNS1831 COG SIOPE NF1 (NF1) A Phase 3 Randomized Study of Selumetinib (IND # TBD) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) associated Low-Grade Glioma (LGG)
Background: Low-grade gliomas (LGG) are the most paediatric common central nervous system (CNS) tumours.Children with the genetic disorder Neurofibromatosis type 1 (NF1) are at inc...
IDENT: Improving Design and analysis of oncology trials Evaluating New targeted Therapies
Background: Phase II clinical trials are often designed to assess whether a new therapy works in patients on average. In cancer trials, however, patients can respond very different...
The heme oxygenase-1 expressing perivascular macrophage subset as a non-redundant facilitator of cancer progression
Background: Tumour associated macrophages (TAMs) are a heterogeneous collection of cell phenotypes, with specialised effector functions that are dictated by the microenvironment in...
PaNanoMRI - Early detection of pre-malignant pancreatic cancer using multifunctional targeted nanoparticles for MR imaging with super-resolution reconstruction and MR fingerprinting
Background: Pancreatic ductal adenocarcinoma (PDAC) is the fifth leading cause of UK cancer death and incidence is rising. Most pancreatic malignancies are diagnosed at a late stag...
Collecting and curating the material culture of contemporary women's bodies
This project investigates the function and value of material culture associated with contemporary women’s experiences of health, such as menstruation, fertility and contraception.D...
Open, reproducible analysis and reporting of data provenance for high-security health and administrative data
In the UK many types of routinely-collected data from the NHS and other government agencies are available for research.To protect privacy, data governance law requires that only pr...
The Child's Speech: speech therapy, stammering, and activism in Britain, 1906-2000
This project will produce a cultural and social history of speech therapy in twentieth-century Britain that is ambitious in seeking to account for the entwined relationship of spee...
Ultrasound-Based Assessment of Brain Folding Patterns in Early Pregnancy
Normal development of the human brain is characterized by precisely timed growth and folding of its surface (cortex).This dynamic process provides a phenotypic report of overall br...
Mechanisms of spliceosome remodeling and splice site selection during the catalytic stage of mammalian pre-mRNA splicing
The spliceosome produces mRNAs in two sequential transesterifications – branching and exon ligation. The post-branching C complex is remodeled by the ATPase Prp16 into the C* compl...
The Molecular Basis of Sister Chromatid Cohesion
Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a prerequisite for faithful chromosome segregation during cell division.The ring-shaped cohesin...
Intravital imaging as a platform for screening checkpoint and focal adhesion kinase inhibitors as potential treatment for cancer metastasis
Despite new developments in treatment, cancer remains the second leading cause of death worldwide. Breast cancer is the most common cancer within the UK, with death generally cause...