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44,293 grants found
Showing 41,341 – 41,360 of 44,293 grants
Structural analysis of Rad51 paralogues involved in recombinational DNA repair
Homologous recombination (HR) is a major mechanism for repairing DNA double-strand breaks (DSBs). A DSB converts one normal chromosome into two pathological chromosomes, making it...
Combining Electrons and Phonons in Twisted materials
The recent discovery of correlated insulating states and unconventional superconductivity in twisted bilayer graphene triggered an intense research effort to understand the propert...
Directed co-evolution via engineered cell-to-cell communication
The aim of this Marie Skłodowska-Curie Fellowship (Evolving Together) is to develop an innovative new system for directed co-evolution of ligand-receptor pairs in two different cel...
DNA4Science: Citizen-science data collection for ethical data re-use
Isolating genetic markers associated with phenotypes (i.e., diseases and behaviour) is one of the most promising frontiers of scientific discovery.Genetics plays a key role in unde...
Supramolecular attack particles to prevent cancer recurrence
Supramolecular attack particles (SMAPs) are proteinaceous particles ~120 nm in diameter released from cytotoxic T cell and natural killer cells.The particles have a core of cytotox...
Photon-Multiplication to Boost Si Photovoltaic Power Conversion Efficiency
Photovoltaics (PVs) cells will play a major role in the worldwide transition to more sustainable sources of energy.There has been a vast scale up in the deployment of PV cells driv...
Efficient and Robust Oxide Switching
We are at the beginning of a Data Age. Data is exploding. In 2016, 90% of the worlds data ever created was in the two previous years. AI and data analytics are further increasing t...
Cold Molecules for Fundamental Physics
Laser cooling of atomic gases in a magneto-optical trap (MOT) has revolutionized modern physics. A MOT uses precisely tuned lasers and a magnetic field to cool atoms and trap them....
EMBedding Responsible Research And Innovation in Future and Emerging TeChnologiEs
Future and emerging technology (FET) research, as performed by EU FET and EIC, aims to create radically novel ideas and technologies that can disrupt and transform human lives, bus...
Feasting networks and Resilience at the end of the British Bronze Age
Exploring how communities respond to economic and climatic crisis is key for enhancing understanding of resilience in the past and present. This project will explore responses to a...
Decision-support for individualised risk assessment of fetal health during labour: preventing fetal brain damage and death by utilising large, routinely collected datasets of cardiotocography and clinical risk factors
Our overarching goal is to improve clinical decision-making around labour management and cardiotocography (CTG) monitoring by providing timely, data-driven and individualised asses...
Using digital health to transform the management of long-term conditions in the NHS: Assessing real-world patient experience and empowerment and improvements to productivity and capacity
Background: Healthcare systems face increasing demands for monitoring and treatment of long-term conditions. Remote digital monitoring avoiding hospital visits offers many advantag...
A phase II study combining pembrolizumab and olaparib in metastatic pancreatic adenocarcinoma patients with high tumour mutation burden
Research QuestionDoes treatment with pembrolizumab plus olaparib improve outcomes for patients with metastatic pancreatic adenocarcinoma (mPDA) and high tumour mutation burden (TMB...
Mucoactive drugs for acute respiratory failure: A 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost effectiveness trial with internal pilot
Research question: What is the clinical and cost effectiveness of mucoactive drugs in acute respiratory failure (ARF)? Design:A 2x2 factorial, randomised, controlled, allocation co...
A PROspective double-blind placebo-controlled multicentre trial of faecal MIcrobiota tranSplantation to improve outcomEs in patients with cirrhosis - PROMISE trial.
There is an evolving crisis of chronic liver disease (CLD) in the UK with prevalence and mortality increasing exponentially. End-stage CLD, termed cirrhosis, is the third biggest c...
Pre-hospitAl Randomised triAl of MEDICation route in out-of-hospital cardiac arrest (PARAMEDIC3)
RESEARCH QUESTION: Population: Adults with out-of-hospital cardiac arrest Intervention: Intraosseous (IO) first strategy Comparator: Current NHS treatment (2 attempts at IV access...
Evaluating the integration of the Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) into primary care and its impact on patient treatment and care.
Research questions: 1. How, when and why is the ReSPECT process used in primary care? 2. What is the impact of the ReSPECT process on patient treatment and care?Background: Emergen...
A person-centred Needs Informed model of Care for people with HIV (NICHE), to improve wellbeing, mental health and reduce socio-economic disadvantages and stigma.
Aims: To improve mental and physical wellbeing in people living with HIV (PLWH), mitigating the effects of social and economic disadvantage and stigma, through developing and evalu...
Optimising people-centred access in primary care in the context of Covid-19: facilitating organisational and policy change
BACKGROUND General practice access is an important policy issue, but previous attempts to improve access have tended to use a very narrow definition of access, and have not taken a...
Pre and post-operative voice therapy: Complex intervention development and feasibility of a voice therapy programme for adults undergoing phonosurgery for benign vocal fold lesions
Background Voice disorders affect one in three people during their lifetime.Consequential time off work alone costs the UK £200 million each year and direct healthcare costs in the...