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44,293 grants found
Showing 41,581 – 41,600 of 44,293 grants
Development of Deubiquitinase Targeted Chimeras (DUBTACs) to Increase Protein Levels.
Ubiquitin is a regulatory protein whose addition to substrates can signal for a protein to be degraded and is also involved in other processes such as trafficking.PROTACs (proteoly...
Using Chemical Biology to Monitor Impact of Metabolic Perturbations on the Regulation of Chromatin State and Drug Action
Organisms respond to environmental changes by adjusting their physiological state, for example switching to oxygen-independent metabolism if oxygen provision is limited. Such copin...
Developing small molecules to dissect the function and mechanism of m6Am methylation
RNA are widely modified and the modifications have a range of effects. One such modification found in animals is the m6A modification. It is found in wide variety of different type...
Natural product inspired leads against Leishmaniasis and Chagas disease
Chagas disease (caused by the parasite Trypanosoma cruzi) and cutaneous and visceral leishmaniasis (caused by Leishmania spp.) are neglected tropical diseases that affect tens of m...
Scottish Public Health in the National Library of Scotland’s Moving Image Archives
Initiatives such as ‘The NHS at 70’ show strong public interest in the histories of public health in the UK.Such discussions have particular resonances in Scotland with the country...
Alert PRO2000 & Cloud Data Platform
Alert Technology Ltd (ALT) developers of the 'Asbestos ALERT' - the world's first real-time warning device for airborne asbestos fibres are now working on the second...
The cellular immune response to B.1.1.7 variant COVID-19 deciphered by single cell multi-omics
Regardless of rapid vaccination programs, the coronavirus SARS-CoV2 is likely to remain a concern for the foreseeable future, because viral pathogens evolve, and acquire mutations...
Learning inequalities during the Covid-19 pandemic: a longitudinal analysis using the UK Understanding Society 2020 and 2021 data
The spring of 2020 saw a widespread and prolonged closure of schools across the UK due to the Covid-19 pandemic. Schools began a phased reopening in July 2021 and in January 2021 c...
Innovative new mass spectrometer for rapid, robust, and detailed data on all components in complex mixtures
Verdel Instruments Ltd, a University of Warwick spin out, is developing an innovative and patented technology which will allow scientists to obtain detailed structural information...
Immune responses to SARS-CoV2 cause activation of platelets, resulting in thrombosis, which can be ameliorated by re-purposed drugs
Severe COVID-19 infection is associated with the formation of blood clots in the lungs and other organs which dangerously compromise their functions and contribute to mortality of...
AI for Radar in an Air Traffic Management System
This PhD investigates and develops Deep Learning classification and explainability methods that can be applied to a safety-critical radar system. Artificial Intelligence (AI) in ci...
TB and COVID-19 coinfection: Investigating the clinical and biological interactions between Mycobacterium tuberculosis and SARS-CoV-2
The novel SARS-CoV-2 and ancient Mycobacterium tuberculosis (M.tb) represent a collision of the public health emergencies and coinfection with these infectious pathogens could have...
COHERE phase 2: Living systematic reviews and evidence and gap map on determinants of COVID-19 Health Related Behaviour
Health-protective behaviours, like washing your hands, wearing a facemask and social distancing, can help to protect people from contracting or transmitting COVID and other similar...
Learning through disruption: rebuilding primary education using local knowledge
This project is intended to inform public debate on how the monies committed to the Education Recovery fund (so far £1.3 billion) can best be used to support pupils in pr...
A single-blind, randomised, phase II UK multi-centre study to determine reactogenicity and immunogenicity of booster vaccination against ancestral and novel variants of SARS-CoV-2 (COV-BOOST)
The 2 vaccines which have been delivered at scale in the UK so far have been the mRNA vaccine BNT162b2 (Pfizer) and the chimpanzee adenovirus vector vaccine ChAdOx1-nCov19 (Oxford/...
Time-resolved Intramolecular Photoelectron Diffraction (TIPD) of Ions in the Gas-phase
Being able to probe structural (electronic and geometric) change on the timescale of atomic motion (femtoseconds) offers the most direct route to understanding the structure-functi...
Microbial Commons: Building a legal instrument for farmers' rights on agricultural microbial resources
Farm management practices have been shown to drive the evolution of specific consortia of agricultural microbial resources that contribute to increased agricultural productivity. T...
Learning Data Driven Medical Checklists For Multi-Disciplinary Consult Scheduling
Checklists are simple tools that are often used to promote safety in clinical applications, because they can easily be integrated into a clinical workflow deployment without the ne...
NSFGEO-NERC Pliocene sea level amplitudes (PLIOAMP)
It is estimated that 5% of the world's population lives on land which is less than 5 metres above current sea level, in communities that are vulnerable to the impacts of sea l...
UltraSOuNd-controlled drug release from Antimicrobial particles for denTAl tissues
Dental caries is the breakdown of the hard dental tissues by the acid produced by bacteria in the mouth. It is recognised that many children and adults suffer unnecessary pain due...