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44,293 grants found
Showing 41,641 – 41,660 of 44,293 grants
AP-001 for the Prevention of Hearing Loss
Anida Pharma is developing AP-001, in the scientific literature referred to neuroprotectin D1 (NPD1), for the prevention of drug-induced hearing loss with the further potential exp...
The role of platelets, and effect of aspirin, on neuroinflammation in TB meningitis
Tuberculosis affecting the brain, called TB meningitis (TBM), is a lethal disease. Brain damage associated with TBM results from our own immune cells working in overdrive. Better u...
The mechanism of recombination and its impacts on human mutation and disease
Meiotic recombination is essential for creation of haploid gametes. Errors in this process cause miscarriage, infertility, and developmental disorders.Recombination proceeds via re...
Emergency Efforts to Sustain UK Government Support for ODA
In the 2020 Spending Review HMG signaled its intent to renege on a manifesto commitment and cut ODA form 0.7 to 0.5% of GNI (on top of the budget cut that happened automatically du...
International Health Advocacy for Climate Action -- GCHA capacity grant
Climate change presents a unique and urgent threat to planetary health.Compounded by the COVID19 pandemic, we face a very real risk of losing 50-years of global development, exacer...
Novel platforms to develop polyspecifically-effective, safe, affordable and thermostable monoclonal camelid VHH nanobodies to treat snake venom-induced necrosis in India and sub-Saharan Africa
400,000 tropical snakebite victims require, every year, life-saving surgical debridement/amputation because there is no medicine to treat the disabling, income-depleting effects of...
The role of epithelial cell extrusion in asthma
Asthma is an airway inflammatory disease, defined by bronchoconstrictive attacks that can be life-threatening. The two essential tissue components of the bronchioles are the airway...
AMR Action Fund
The AMR Action Fund aims to bridge the funding gaps and technical barriers that antibiotic developers face as they head into later-stage development and ensure new treatments for d...
ACORN 2.0 - A Clinically Oriented antimicrobial Resistance Network
The ACORN project will establish a network of hospitals and clinical laboratories in Asia and Africa to implement efficient patient-focused antimicrobial resistance (AMR) surveilla...
Developing small molecules as a neurosteroid replacement strategy for treating postpartum psychosis
This project has the potential to ultimately deliver significant patient impact in the relatively neglected area of maternal mental health.In the short term, the funding requested...
Finding treatments for COVID-19: A phase 2 multi-centre adaptive platform trial to assess antiviral pharmacodynamics in early symptomatic COVID-19 (PLAT-COV)
We propose to set up and validate a pharmacometric platform to provide quantitative assessment of antiviral effects in low risk adult patients with recent onset uncomplicated COVID...
Epidemic Inteligence: Understanding how returning migrant waves drive epidemic seeding and community transmission events in the South Asian context to inform epidemic preparedness
Nepal, as for much of Asia, has high levels of labour migration, particularly to neighbouring India and the Middle East. The SARS-CoV-2 pandemic has caused a chaotic mass return mi...
Increasing compliance with Active surveillance: A randomised trial evaluating the role of Finasteride
The study is a randomised controlled CTIMP in men with newly diagnosed low/intermediate risk localised prostate cancer. We will randomise 550 patients to Active Surveillance with o...
Experiences of diagnostic pathways and cancer care during the COVID-19 pandemic
BACKGROUND: COVID-19 led to the disruption of cancer care services in the UK, including a major decrease in urgent cancer referrals and treatment attendance and delivery. This will...
Epigenetic Memory: Understanding how epigenetic information is transmitted and changed during normal development and in disease
Our team examines how cellular identity is established, progressively changed during differentiation and then transmitted through cell division.Understanding how epigenetic informa...
Computational Cardiac Imaging
Cardiovascular diseases are a diverse range of conditions that affect 8 million people in the UK with a cost to the UK economy of £16 billion each year.Cardiac imaging provides a r...
Inflammation and Obesity
Our group studies the complex interplay between environment, inflammation and metabolic disease.Environmental factors, such as diet and intestinal microbiota, are important modulat...
Towards a more comprehensive assessment of pulmonary vascular phenotypes by magnetic resonance-augmented right heart catheterisation
Patients with pulmonary hypertension (PH) continue to have high mortality even with the availability of advanced therapies for PH.Despite a common haemodynamic definition for all c...
The invasive surgical procedure infective endocarditis association study (The I-SPIE association study)
Infective endocarditis (IE) is a life-threatening cardiac infection with ~30% one-year mortality.A near doubling of IE incidence has occurred in England in the last 10-years, but t...
How does personalising the heart-rate programming of cardiac implantable electronic devices in patients with heart failure due to reduced ejection fraction improve exercise time and promote better left ventricular function? (Dr Samuel Straw)
Background: The cardinal symptom of heart failure with reduced ejection fraction (HFrEF), exercise intolerance, is thought to be exacerbated by limited heart-rate (HR) rise.However...