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44,293 grants found
Showing 41,661 – 41,680 of 44,293 grants
The impact of venous outflow obstruction on venous return to the heart - preload, cardiac function and exercise tolerance (Dr Rachael Morris)
Post-Thrombotic Syndrome (PTS) affects up to 50% of patients who develop thrombosis in the proximal (inferior vena cava, IVC or iliofemoral, IFV) veins.Chronic fibrotic changes, oc...
Myocardial adaptation and reverse remodelling in aortic regurgitation: Integrating invasive and non-invasive phenotyping by CMR and biopsy (Dr George Thornton)
Current guidelines for the management of severe chronic aortic regurgitation (AR) advocate surgical aortic valve replacement (SAVR) when the heart dilates, becomes impaired or when...
Targeting mitochondrial metabolic and redox status to treat ischaemia/reperfusion injury
Ischaemia/reperfusion (I/R) injury underlies many pathologies, including myocardial infarction (MI) and stroke, which account for more than a third of overall mortality in the UK.F...
Molecular basis of endoglin function in cardiovascular diseases
The aim of my fellowship is to investigate molecular mechanisms of endoglin (ENG) function using structural and biochemical approaches and to validate the findings in human and mur...
Mitochondrial function in doxorubicin-induced cardiotoxicity
Doxorubicin (DOX) is a chemotherapeutic drug that can cause serious cardiotoxic side effects leading to heart failure.Different mechanisms have been proposed for this toxicity, tho...
Characterising a new family of glycoside hydrolases that target mycobacterial cell wall glycans
The cell walls of pathogenic mycobacteria including the causative agent of Tuberculosis, M. tuberculosis, contribute to their pathogenicity and resistance to many common antibiotic...
Molecular coordination between cytoskeletal networks in collective cell migration and its impact on development and disease
The overall goal of this research is to gain in-depth understanding of the molecular mechanisms underpinning gut disorders to ultimately discover new biomarkers for early detection...
EPSRC Physics of Life
This partnership between Wellcome and UKRI will support the Physics of Life funding call.Which aims support internationally leading research that requires collaborative, interdisci...
System for Kinematic Assessment of Painful Knees with Ultrasound Imaging
Development of a system and protocol for measuring in vivo patella tracking during knee flexion using ultrasound imaging in clinics.With a tracked ultrasound scan of the knee using...
Development and evaluation of a medical device to monitor arthritis patients at home
The purpose of this proposal is to develop and evaluate a prototype device, which can monitor the condition of someone with arthritis at home.The proposal scope involves gathering...
Long-term intraarticular delivery of glucocorticoids from novel particles
Glucocorticoids (GCs) are potent anti-inflammatory and analgesic treatments in musculoskeletal diseases and when delivered intraarticularly in arthritic joints they are amongst the...
Characterisation of tissue-resident immune crosstalk in human pancreatic neoplasms and pancreatitis via single-cell transcriptomics
Background Pancreatic cancer is projected to become the second leading cause of cancer mortality in the late 2020s. The current 5-year pancreatic adenocarcinoma (PDAC) survival is...
T-cell Receptor Profiling in Early Stage Breast Cancer
Background Immunotherapies have transformed cancer treatment and how we understand and interpret the tumour microenvironment.Furthermore, it is becoming increasingly apparent that...
Hamlet.rt: multi-centre expansion
Background Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy (Hamlet.rt) is a technology-enabled prospective clinical study aiming to build...
Exploiting membrane dynamics to target the assembly of the metastatic matrix niche in ovarian cancer
BACKGROUND Ovarian cancer has a 5-year survival of only 40% and the outlook is worse for the most common form, high-grade serous ovarian cancer (HGSOC). The major lethal step in HG...
Deciphering the Genomics of Aggressive non-Hodgkin Lymphoma
Background To unravel the biological basis of aggressive non-Hodgkin lymphomas (aNHL), we and others have performed large mutational profiling studies. These reveal considerable ge...
Young people’s engagement with e-cigarettes and their marketing: a mixed-methods, engaged project to co-produce recommendations for policy
Background: While adults’ use of e-cigarettes appears to be stable, evidence suggests that experimentation among young people has increased.Despite differences in opinion within th...
Third Biennial European Network for the Study of Cholangiocarcinoma
Background: Cholangiocarcinoma is a cancer of the ducts in the liver and its incidence is increasing.Currently there are few curative options and as a result, five-year survival ha...
ELECTRA – intraoperativE eLECtron radioTherapy in Rectal cAncer
Background Colorectal cancer is the third most common cancer in the UK and represents the second highest cause of cancer mortality and cancer-related health care expenditure.The re...
TEP-eDx: Validating the use of Tumour Educated Platelets for early cancer diagnosis
Earlier detection greatly improves outcomes for patients with cancer, and studying the gene changes in cancer cells greatly helps in identifying risks and 'tailoring' tre...