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44,293 grants found
Showing 41,681 – 41,700 of 44,293 grants
Reducing neurotoxicity from brain irradiation with FLASH radiation and PARP inhibitors
Background: The combination of PARPi and FLASH is of particular interest as both are shown to be modulated by the available oxygen in the irradiated tissue, which increases the pos...
Early detection of prostate cancer in the general practice setting: The BARCODE1 Study
Background The discovery of the code of the human genome has led to the anticipation that this will be able to transform healthcare.It is hoped that this will enable identification...
Self-DNA Detection in Genome Maintenance and Cancer
Background Most cancers, either during their development, or during chemotherapy, undergo genotoxic stress and chromosomal instability.While much is known about how classic DNA rep...
The Cancer Research UK Newcastle Drug Discovery Unit (2021-2025)
Background: The CRUK Newcastle Drug Discovery Unit (DDU) is an integrated, interdisciplinary team of cancer biologists, pharmacologists, structural biologists and medicinal chemist...
Deciphering the processes driving metastatic disease and death in lung cancer
Background There are numerous ways in which cancers are thought to lead to death and whilst many studies have highlighted processes contributing to metastatic disease, we lack a un...
E-cigarette and cigarette use trajectories among young people in England: a cross-sectional, retro- and prospective analysis of the Smoking Toolkit Study
Background: E-cigarettes are an effective harm reduction and cessation aid.However, there are concerns regarding their impact on youth, particularly gateway effects leading to the...
YOUTH RESPONSES TO E-CIGARETTES, E-CIGARETTE RETAILING, AND E-CIGARETTE PACKAGING IN ENGLAND, CANADA, AND THE UNITED STATES
Background: There are concerns that e-cigarette use (vaping) among youth may lead to exposure to nicotine and other constituents, nicotine addiction, and progression to tobacco smo...
Development of rejection-resistant allogeneic chimeric antigen receptor T cells
Chimeric antigen receptor (CAR)-T cells are a breakthrough in cancer treatment, recently approved in advanced B cell malignancies.An important limitation is that CAR-T are currentl...
Predicting endoleaks following endovascular aneurysm repair
Abdominal aortic aneurysms are a leading cause of death in the United Kingdom. Surveillance programmes and pre-emptive surgical repair are lifesaving.Traditional open surgical repa...
The Biosocial Lives of Birth Cohorts
This four year project examines birth cohorts as sites of knowledge, practice and participation in the UK, Europe and Latin America. It aims to understand how they provide an infra...
Clinical Trial Community Engagement Lab
Community engagement is an essential component in clinical trials, and it is regarded as an ethical requirement of most ethics review committees before the trial protocols can be a...
Multimorbidity and Knowledge Architectures: An Interdisciplinary Global Health Collaboration
As people live longer, the coexistence of multiple conditions in one individual – ‘multimorbidity’ – becomes more common.Scholars across the biomedical sciences have expressed conc...
What causes lacunar stroke? A 7T magnetic resonance imaging study
Lacunar stroke results from ischaemia in the territory of the small perforator arteries which supply the white matter and deep grey matter. It causes a quarter of all stroke and is...
Regulation of TP thromboxane receptor expression and activity by selective P2Y12 receptor antagonists in human platelets: Consequences for dual antiplatelet therapy?
Activation of platelet expressed G protein-coupled receptors (GPCRs) by TxA2 (TP receptor) and ADP (P2Y1 and P2Y12R) plays a central role in the development of the arterial thrombo...
Multi-dimensional Diagnostics for Rapid Detection of Infectious Diseases in Developing Countries
This proposal will build capacity and assemble a multidisciplinary international team to produce fundamental cutting-edge technology and biological methods to deliver user driven,...
Disentangling relationships between genotype and phenotype in complex genetic disorders, with particular application to liver and kidney disease
The main goal of this research is to develop and apply advanced statistical methods to help elucidate the biological mechanisms and causal pathways underpinning the correlations se...
Could vaccinating at risk populations with Meningococcal B vaccine reduce incidence and antimicrobial resistance in gonococcal infections in the UK?
Antimicrobial resistance (AMR) threatens public health and individual patient care. Gonococcal (GC) infection incidence has been increasing year on year for the last decade in the...
Vaccines and the evolution of antibiotic resistance: elucidating transmission mechanisms and public health impact using deep sequencing of Streptococcus pneumoniae and mathematical models
Vaccines can, in principle, alleviate antibiotic resistance by preventing infections and reducing the need for antibiotic use.However, the impact of pneumococcal conjugate vaccines...
Bridging the gap: biophysical models of human frontotemporal lobar degeneration
To treat and prevent dementia in patients, it is essential to understand how microscopic changes in the human brain cause complex cognitive and behavioural disorders.My program add...
Targeting the gut in metabolic disease
This project aims to identify new strategies to target the gut for the treatment of type 2 diabetes and obesity.Intestinal hormones regulate intestinal nutrient absorption, insulin...