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44,293 grants found
Showing 41,721 – 41,740 of 44,293 grants
The assembly and structure of the chloroplast protein import machinery in plants
Plants convert solar energy into chemical energy by the process called photosynthesis in a specialized compartment of the cell known as chloroplasts.Chloroplasts are majorly enrich...
COhort cOmmunity Research and Development Infrastructure Network for Access Throughout Europe
The aspiration to secure the wellbeing of children and young people is explicit in Grand Challenges such as the UNs Sustainable Development Goals. The EU has similarly highlighted...
Deciphering the mechanism of the dual functional E3 ligase TRIM28 in cancer cells
TRIM family proteins are RING-type E3 ubiquitin ligases with important roles in immune responses, autophagy and cellular signalling.They are characterised by the presence of an N-t...
Quantum Thermodynamics in the Solid-state
I propose to realize an electromechanical engine in the solid state, opening a new era of experimental exploration of thermodynamics in open quantum systems.This project leverages...
Evaluating treatment response mechanisms of Rituximab and Tocilizumab in Rheumatoid Arthritis in the R4RA randomised clinical trial
BackgroundThe proposed research capitalises on the NIHR-EME funded R4RA Randomised Clinical Trial (RCT) to evaluate the mechanisms of action of Rituximab (RTX) and Tocilizumab (TOC...
Textuality, Place, and the Self: Reimagining Life Writing through Women’s Diaries from Ireland, 1725-1810
DIARIES will enable the experienced researcher, Dr Amy Prendergast (AP) to undertake a 24-month fellowship – Textuality, Place, and the Self: Reimagining Life Writing through Women...
A mixed-methods investigation of the delivery, impact and acceptability of a national de-adoption programme across Clinical Commissioning Groups in the English National Health Service
BACKROUND: The National Health Service is under intense pressure to maintain and improve services with limited funds. New evidence relating to currently adopted treatments can some...
Suicidal ideation, homicidal ideation, and self-harm in parent carers.
Background Emerging research suggests family carers are a high-risk group for suicide, homicide, and self-harm. Only three studies, however, have focused on parent carers and none...
A randomised controlled trial of TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation (TRANSLATE) of potential clinically significant prostate cancer
Research Hypothesis: LATP biopsy improves detection of clinically significant PCa, and decreases infection rates, compared to TRUS biopsy.Background: Prostate cancer (PCa) is the c...
Supporting the spread of effective integration models for older people living in care homes: A mixed method approach
Research question: The project seeks to identify, classify and compare the types and extent of locally-implemented integrated care policies in relation to care homes in England. Ba...
Exploring the use of pre-hospital pre-alerts and their impact on patients, Ambulance Service and Emergency Department staff.
Research questionHow are out of hospital pre-alert decisions made and communicated and what is the impact of these pre-alerts on receiving Emergency Departments (EDs) and patients?...
A patient-reported questionnaire to measure the use of informal care, social care and personal expenses
Background To assess the value for money that new interventions offer to the NHS and to society, it is necessary to measure both the benefits gained and the resources used. Typical...
Clinical Evaluation, Development and Commercialisation of an Antimicrobial – Impregnated Catheter Against Peritonitis (The CAP Study)
Research question: Is an antimicrobial peritoneal dialysis (PD) catheter impregnated with rifampicin, sparfloxacin, and triclosan well-tolerated by patients and do these data suppo...
The impact of Care Act Easements under the Coronavirus Act 2020 on co-resident older carers of partners with dementia
The Coronavirus Act 2020 contains the unprecedented power for local authorities to suspend the majority of their duties within adult social care under the Care Act 2014, leaving on...
Lessons from the health and wellbeing response to the Grenfell Tower Fire: A multi-methods approach
Research Questions: How did statutory agencies decide on the content and structure of the mental health and wellbeing response to Grenfell? Why did they take the decisions they did...
Quantum Nanomaterials by Twistronics
Van der Waals heterostructures, assembled from 2D materials, offer unprecedented opportunities for the material design by layer-by-atomic-layer construction of artificial solids.Th...
NIHR Senior Investigator Award
NIHR Senior Investigator Award
NIHR Senior Investigator Award
NIHR Senior Investigator Award
NIHR Senior Investigator Award
NIHR Senior Investigator Award
Mental capacity and personal finances: a qualitative study of assessment and support
Research questions What are (a) the legal, policy, professional and practice frameworks, and (b) the public information available to guide financial capacity assessments and suppor...