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44,293 grants found
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NIHR Pre-doctoral Fellowship (Round 2)
Training Award
Implementation of the non-medical practitioner workforce into the urgent and emergency care system skill-mix in England: a mixed methods study of configurations and impact.
Primary research question:What is the impact of different non-medical practitioner skill-mix in Emergency Departments (ED) and Urgent Treatment Centres (UTC) in acute hospitals on...
HEE/NIHR ICA Pre-doctoral Clinical Academic Fellowship 2020
Training Award
NIHR Pre-doctoral Fellowship (Round 2)
Training Award
ECONOMIC EVALUATION OF MULTI-SECTOR OBESITY POLICY
Background Obesity is caused by largely preventable risk factors linked to unhealthy diets and physical inactivity.Increasingly, calls have been made for system-wide action with an...
Digital solutions for people with severe mental health problems
Background: Worldwide, mental health is in crisis: we cannot accommodate the majority of those in need. Psychosis is a severe mental health problem (SMI) and a huge public health c...
HEE/NIHR ICA Pre-doctoral Clinical Academic Fellowship 2020
Training Award
A smart wearable technology for people with Parkinson's
A smart wearable technology for people with Parkinson's
Evaluating the safety and patient impact of an Artificial Intelligence Command Centre in the UK National Health Service
Background:Command centres in safety critical industries are well-evolved and linked to reliability, resilience and shared situational awareness for operational control. In the saf...
Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)
Research question: In critically ill adults with metabolic acidosis and acute kidney injury (AKI) [Population], is treatment with intravenous (IV) 8.4% sodium bicarbonate [Interven...
A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers: the REACH-HFpEF Study
AIMTo assess the clinical effectiveness and cost-effectiveness of home-based cardiac rehabilitation programme ‘REACH-HF’ plus usual care (intervention) versus usual care alone (con...
The Self-harm, Assessment, Formulation, Engagement Trial of Psychodynamic Interpersonal Therapy (SAFE-PIT)
RESEARCH QUESTION: Is brief psychodynamic interpersonal therapy (PIT) plus best care effective for people who attend hospital following self-harm (SH) compared to best care?BACKGRO...
Therapies for Long COVID in non-hospitalised individuals: From symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study)
Background Approximately 1 in 20 individuals with COVID-19 experience symptoms and impaired quality of life beyond 12 weeks ( Long COVID ). Long COVID may comprise several distinct...
Cost-effectiveness of osteoporotic fracture risk assessment in people with intellectual disabilities
Research question: What is the most cost-effective method for osteoporotic fracture risk assessment in people with intellectual disabilities?Background Our originating study &l...
General practice service use towards end-of-life among patients who died before and during the COVID-19 pandemic: a nationwide cohort study using the Clinical Practice Research DataLink
RESEARCH QUESTIONS What were the characteristics of the patients who died before and during the pandemic? What were the reasons for end-of-life patients accessing general practice...
TDP-43 Misregulation in neurodegeneration
TDP-43 is a conserved RNA binding protein central to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 normally autoregulates its ex...
Structural mechanism of genome acetylation and 3D folding
Recent chromosome capture experiments have revealed a hierarchical 3D organisation of the genome ranging from Topologically Associating Domains (TADs) to larger-scale active, euchr...
Maternal and Infant Lactation pharmacoKinetics (MILK)
Worldwide many women require drug treatment during breastfeeding, but data surrounding transfer of drug from mother to breastfed infant are scarce and of very low quality.This fell...
Determining the limits for reversing hearing loss
Progressive hearing loss is very common but there are no medical treatments to slow down or reverse it.Histopathological reports suggest three main sites of lesion in the cochlea c...
Conformational Surveillance of signalling proteins in the plasma membrane
The distinct activities of polytopic channels, transporters and receptors are essential for cell signalling in response to external stimuli, and their dysfunction is frequently ass...