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44,293 grants found
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Long Covid: Amplifying the voices of people with lived experience to improve understanding, support, treatment and education. Share-to-improve: Long Covid experience (COv-VOICES) Study
COVID-19 is a new virus.Media stories often talk about the numbers of people who die from COVID-19, or about people who are hardly affected and recover quickly.We will conduct a st...
Developing And Validating A Risk Prediction Model For Long COVID-19
Most patients with coronavirus disease 2019 (COVID-19) recover within a few weeks. However, around 10-20% of people continue to have symptoms that last for many weeks or months.The...
‘DuoChol: A low-cost, thermostable dry formulation whole-cell / B-subunit enterocoated capsule oral cholera vaccine.’
Our vision is to develop a novel, much improved oral cholera vaccine (OCV) which will substantially contribute to achieving WHO´s stated goals to reduce cholera deaths by at least...
Developing electroencephalography as a tool to predict delirium and long-term cognitive outcome after traumatic brain injury.
Approximately 1 million patients are hospitalised every year in Europe after Traumatic Brain Injury (TBI).The most severe TBI patients are admitted to Intensive Care Units (ICU) an...
Living ‘Addiction’ in states of disruption: a transdisciplinary approach to drug consumption and recovery in the Middle East
This project tackles the question of how people in the Middle East have experienced ‘addiction’ and how governments and social agents have reacted to changing drug phenomena in sta...
Functional analysis of the lncRNA MIR503HG in endothelial cell identity and endothelial-to-mesenchymal transition
Endothelial-to-mesenchymal transition (EndMT), a dynamic biological process with functional importance in cardiac development, is involved in a variety of pathological vascular rem...
Altered myocardial calcium-handling in patients with diabetes mellitus or heart failure (Dr Shruti Joshi)
In patients with diabetes mellitus, cardiovascular disease and heart failure associated are the leading causes of complications and emergency admissions in the United Kingdom with...
Structure, Function and Chemical Biology of Nucleic Acids
Background We have established an integrated programme of fundamental research to elucidate the structure and function of nucleic acids through the application of chemical biology....
PRISM - Machine Learning for Discovery of Pre-neoplastic signature in Mesothelioma
Background: Malignant pleural mesothelioma (MM) is a highly aggressive cancer and has a five-year survival rate of less than 10% from diagnosis.The prognosis of patients with MM is...
c-REL transcriptional programmes driving atherosclerosis (Ms Priscila Hirschfeld)
Atherosclerosis, a disease leading to angina, heart attack or stroke, is initiated at regions of arteries that are exposed to disturbed blood flow, which generates low wall shear s...
Generation of beta cells from stems cells using novel regulators
Diabetes is a chronic condition that occurs when the pancreatic beta-cells are destroyed or cannot secrete enough of the hormone insulin to keep up with the demand.Cell replacement...
Next Generation T-cell therapies for CMV post-allogeneic stem cell transplant
Funding is requested to support a Phase I, single-centre, open-label clinical trial of Glucocorticoid Receptor (GR) knockout CMV-specific T-cells (CMV-ko) for an unmet clinical nee...
Tracing the dynamics of epithelial cell competition in normal and perturbed states
The mechanisms that regulate cell fate promise fundamental insights into the pathways that promote tumour growth.Through advances in genetic lineage tracing and single-cell profili...
Imaging the Redox Microenvironment to Predict Tumour Resistance to Therapy
The majority of lung cancer deaths result from ineffective treatment of late-stage disease. Currently, there is no satisfactory way to identify patients that will not respond to st...
Specialization of chromosome segregation mechanisms in meiosis
Meiosis generates gametes with half the parental genome through two consecutive chromosome segregation events, meiosis I and meiosis II.Meiotic errors are prevalent in humans, acco...
Checkpoint control of T cell-B cell collaboration in the regulation of autoimmunity
Productive communication between T cells and B cells is vital for protective immunity, however dysregulation of this process can trigger autoimmunity.Costimulatory checkpoints limi...
Intimate partner violence against women in low- and middle-income countries: associations with parenting practices and early childhood development.
The 2030 Agenda for Sustainable Development highlights the need to prevent and respond to violence against women and girls.It also affirms the need to invest in early childhood car...
Understanding the mechanisms of multimodal communication in deaf children with cochlear implants
Children develop and interact in complex, multimodal environments.I will investigate how deaf children with cochlear implant (CIs) integrate visual information from the talker’s fa...
Myocardial energy starvation and ketone metabolism in patients with type 2 diabetes
Patients with type 2 diabetes(T2D) are ‘cardiac energy-deficient’ and this deficiency contributes to their excess heart failure(HF) risk.The key mechanisms for cardiac energy defic...
Recombinant snakebite antivenom for sub-Saharan Africa
Sub-Saharan Africa (sSA) is heavily burdened by snakebite envenoming. Existing antivenoms are scarce and many have suboptimal therapeutic properties.To improve snakebite envenoming...