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44,293 grants found
Showing 42,741 – 42,760 of 44,293 grants
Exploring innate-like and adaptive gamma delta T cell paradigms in health and disease
γδ T-cells have been retained in vertebrates for ~500million years, and are of increasing therapeutic interest, but their mode of ligand recognition and immunological niche has rem...
Defining the role of edited microRNAs in diabetes mediated brain microvasculature alterations
Type-2 diabetes (T2D) mediated hyperglycaemia is associated with an array of negative intracellular events that promote endothelial cells (EC, specialised cells that cover internal...
Use of capillary blood ketone meters to improve ambulance service care of hyperglycaemic patients: a feasibility study (KARMA2 study)
Ambulance clinicians do not have blood ketone meters: they rely on nonspecific clinical signs and symptoms for hyperglycaemic care strategies.Hospital-based guidelines advocate imm...
Role of the GSK3-NRF2 axis in beta cell decline in type 2 diabetes
Type 2 diabetes occurs when insulin production from pancreatic beta cells is insufficient to prevent the hyperglycemia that defines diabetes.Insulin production declines during prog...
Is adult health trajectory determined by maternal glucose levels during embryo implantation?
Diabetes profoundly affects the outcome of pregnancy, especially when glucose control is poor.We hypothesise that high glucose levels alter endometrial function, affecting the dial...
Can Breaks from Sitting Improve Glucose Control and Vascular Health in People with Type 1 Diabetes?
Sedentary lifestyles significantly increase morbidity and mortality, with prolonged periods of sitting detrimental to diabetes management and risk of complications.Although the Nat...
Unravelling the molecular mechanisms of invasive pneumococcal disease
Invasive pneumococcal disease causes over a million deaths per year worldwide, particularly in sub-Saharan Africa. Streptococcus pneumoniae strains vary considerably in virulence,...
TopFlow: (in)visible water flows near the surface
overland flow
Many-Body localization in discrete quasiperiodic potentials
quasiperiodic systems
Revolutionising Sensing as a Service for industry towards a more sustainable future
**ME:** An innovator and leader, my career started in engineering defence and has continued for the last 20-years in innovation. I am an award-winning mechanical engineering gradua...
ConBioChem: Continuous bio-production of commodity chemicals
Abstracts are not currently available in GtR for all funded research.This is normally because the abstract was not required at the time of proposal submission, but may be because i...
Brainwide neural populations supporting multisensory decision-making
To represent the external world and make appropriate decisions, brains need to combine information from different sensory modalities. This process is ubiquitous and vital, whether...
Learn.ink - building for scale
Georgia Barrie is the CEO of Bristol-based social enterprise Farm.ink. Farm.ink has been developing award-winning mobile services for small-scale farmers for over four years, winni...
Transcriptional control of human epidermal stemness.
In everyday life our skin has to cope with a lot of wear and tear. The epidermis forms the surface of the skin and is made up of several layers of cells. The epidermis needs to be...
Seeing How You Feel: Multisensory Enhancement Of Touch In Ageing
Touch perception is important for feeling shapes, textures and materials, for identifying dirty vs clean surfaces, for balance and it can evoke detailed memories or emotions. Being...
Climate change action is not a game... it is now!
Dr Emma Fieldhouse is a career environmentalist, inspirational teacher and Director of her own business. She is passionate about changing the perception of sustainability and clima...
Direct-to-consumer genetic testing and donor-conception: support and governance in emerging digital systems
The growth in the use of direct-to-consumer-genetic testing (DTCGT) is having a major impact on sperm, egg and embryo donor conception (hereafter donor conception). Specifically, i...
HEE/NIHR ICA Pre-doctoral Clinical Academic Fellowship 2019
Training Award
Diet and physical activity in pregnancy to prevent gestational diabetes: Individual Participant Data (IPD) meta-analysis on the differential effects of interventions with economic evaluation
BACKGROUNDMothers with gestational diabetes (glucose intolerance diagnosed for the first time in pregnancy) are at high risk of complications in pregnancy, and of type 2 diabetes i...
Developing A Quality Standard To Deliver Evidence-Based Pain Management To People With Inflammatory Arthritis.
Background Inflammatory arthritis is an umbrella-term for diseases involving immune-driven joint inflammation.Its three main forms - rheumatoid arthritis (RA), psoriatic arthritis...