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44,293 grants found
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Pericardial applied left ventricular assist device (PAL-VAD): Evaluation of chronic performance, optimisation and completion of a first-in-human feasibility study
Heart failure affects hundreds of thousands of people in the UK.It occurs when the heart is unable to pump as well as it should, meaning it is less able to supply the rest of the b...
Epidemiology and predisposition of acute stress-induced (Takotsubo) cardiomyopathy (Ms Amelia Rudd)
Takotsubo cardiomyopathy is characterised by sudden onset left ventricular dysfunction precipitated by major stress.This left ventricular dysfunction appears to recover rapidly, bu...
Dissecting the role of caudal brainstem corticotropin-releasing hormone signalling and preproglucagon neurons in anxiety-related sympathoexcitation
For decades the comorbidity of affective disorders and cardiovascular disease (CVD) was simply attributed to poorer health choices, including smoking and obesogenic diets.While thi...
Determining the impact of a genetic diagnosis in patients and families with dilated cardiomyopathy (Dr Douglas Cannie)
Dilated cardiomyopathy (DCM), defined as dilatation and systolic impairment of the left ventricle not attributable to abnormal loading conditions or coronary artery disease, is a c...
Enzymes Encapsulation in Peptide-based Nanodroplets for the Degradation of Organophosphate
The use of pesticides in agriculture has widely spread in order to increase the yield while maintaining food quality and safety.The use of pesticides allows for effective and rapid...
Cancer-associated fibroblasts: culprits or victims in cannibalism of oral squamous cell carcinoma cells?
The purpose of this study is to evaluate whether cancer-associated fibroblasts (CAF) promote cannibalistic activity of oral cancer cells and/or act as targets of these cells.TCC ha...
The influence of cash transfer programme on mental health and school performance among young people exposed to violence in Brazil
Introduction: Mental health problems-MHP are a leading cause of disability in children/adolescents worldwide and are linked to poverty and violence, leading to restrictions in inco...
A multi-omics study to dissect the role of the gut microbiome in IgA nephropathy risk
Immunoglobulin A (IgA) nephropathy (IgAN) is the most common form of glomerulonephritis, with high prevalence in both Chinese and European populations. IgAN can be mild, or progres...
A Fluorophore-nanoparticle Composite Designed for the Early Stage Diagnosis of Alzheimer's Disease
The seeming unstoppable rise of Alzheimer's disease (AD) worldwide represents a significant and challenging public health problem.However, early diagnosis of AD can enable imp...
Loss of natural indigenous habitats and adolescent mental health in Latin America and Caribbean
Background: Climate change is a public health threat for the entire Latin American and Caribbean (LAC) region, which contains many low- and middle-income countries with fragile eco...
Versus Arthritis National Experimental Arthritis Treatment Centre for Children
The Experimental Arthritis Treatment Centre for Children (EATC4Children) is the UK’s first and only EATC4Children.It represents a unique consortium that was created in 2014 through...
The genomic and phenotypic characterisation of inflammation, injury and repair in the oesophagus
Background Recent advances in whole genome sequencing have shown that somatic mutagenesis is not unique to cancer.Non-cancerous diseases of the oesophagus are rising in incidence w...
Cellular responses to DNA damage
Background.Gaining a better understanding of the causes and consequences of DNA damage, and the cellular systems that respond to such damage, is of huge importance for cancer resea...
Cellular and molecular characterisation of epithelial tumour initiation
Background My research focus is driven by the fact that we still have little understanding of how hundreds of identified genetic aberrations impact tissue homeostasis leading to tu...
Investigating heterocellular signalling in the micro-metastatic stage of colorectal cancer recurrence in the liver
Background: Despite adjuvant chemotherapy, over 30% of Stage III (node-positive) colorectal cancer (CRC) patients suffer post-operative recurrence, which is most frequently seen in...
Developing immunostimulatory antibodies to deliver agonism without toxicity
• Background Monoclonal antibodies (mAb) targeting immune checkpoints such as CTLA-4 and PD-1/PD-L1 have transformed therapy for some types of cancer in a proportion of patients. D...
A label-free and real-time Graphene bioSensor for exosome-driven point-of-care detection of early CANcers (Gr-SensorCAN)
Background Developing reliable, ultrasensitive, simple, real-time, and non-invasive cancer diagnostic tools is crucial to tackle cancer at very early stage. Meanwhile, findings of...
Exploring loco-regional heterogeneity in head and neck squamous cell carcinoma within the ART DECO trial
Background Head and neck squamous cell carcinoma (HNSCC) can be cured by radical radiotherapy, often in combination with chemotherapy.Approximately half of people treated in this w...
Dynamics of T-cell driven immune responses to radiotherapy in a murine model of melanoma
Background: Radiotherapy has been shown to lead to anti-tumour immune responses and there is increasing interest in developing rational treatment strategies to bolster this effect....
A single cell mRNA atlas of rhabdomyosarcoma at presentation and relapse - identifying foetal developmental targets (co-funded by Children with Cancer UK)
BACKGROUND Following dramatic improvement in the outlook of children suffering from RMS in the 1970s and 1980s, progress has stalled since, in spite of extensive clinical and biolo...