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44,293 grants found
Showing 42,801 – 42,820 of 44,293 grants
Harnessing extrachromosomal circular DNA for liquid biopsy analysis
Background Liquid biopsy analysis refers to methods designed to detect tumour-specific material (e.g., circulating tumour cells or tumour DNA) in body fluids, such as urine or bloo...
Targeting MYC through next generation structure-function
Background: It is estimated that dysregulation of MYC occurs in over 70% of all human cancers, making it one of the most enticing targets for cancer drug development. However, no e...
Multimodality Early Detection of Head and Neck Cancer Recurrence
The optimal frequency of post-treatment imaging surveillance for head and neck cancer patients who are at risk of recurrence is not well-defined and non-imaging biomarkers for recu...
Developing drugs for the treatment of Epstein-Barr virus-associated cancers using more widespread targets
Epstein-Barr virus (EBV) causes 200,000 lymphomas and carcinomas world-wide each year.These include Burkitt’s lymphoma (BL), Hodgkin’s lymphoma, diffuse large B cell lymphoma, post...
Development and characterisation of a DNMT3A mutant cell line model of clonal haematopoiesis
Background DNMT3AR882H/C is a common mutation of the de novo DNA methyltransferase in clonal haematopoiesis of indeterminate potential (CHIP) and increases risk of progression to A...
Interactions between Cognitive Impairment & Transport in Urban Environments (IN-CITU)
Novel social and cognitive science, approaching people and places as indivisible assemblages, challenges dementia research’s traditional humanism (people as exceptional entities) a...
NIHR Development and Skills Enhancement Award
Training Award
NIHR Development and Skills Enhancement Award
Training Award
Miglustat in Tangier disease (MUSTANG)
BACKGROUND: Tangier disease is an ultra-rare inborn error of metabolism, leading to neuropathy and cardiac disease. The only established treatment is low fat diet – but this slows...
Type 2 Diabetes (T2D) in 16 – 40 year olds: A Multifactorial Management Intervention to Address Multimorbidity in Early-Onset T2D in Adults (The M3 Research Programme)
Background The prevalence of type 2 diabetes (T2D) in younger individuals is increasing.Adults with early-onset T2D (defined as 16-40-years) typically display an extreme risk pheno...
NIHR Development and Skills Enhancement Award
Training Award
Preventable infant deaths: Improving uptake of safe sleep messages in high-risk families
5.1 Research question How will an intervention targeted to families most at risk, improve safety for babies during sleep, and reduce Sudden and Unexpected Deaths in Infanc...
Developing a strategy for implementation of risk stratification into bowel cancer screening programmes
Background Colorectal cancer (CRC) is the second leading cause of cancer-related death in the UK. There is good evidence that screening adults in the general population reduces CRC...
NIHR Pre-doctoral Fellowship (Round 2)
Training Award
NIHR Pre-doctoral Fellowship (Round 2)
Training Award
NIHR Development and Skills Enhancement Award
Training Award
Autonomous cardiac MR Acquisition
Background Cardiac magnetic resonance (CMR) is the gold standard for the diagnosis and evaluation of many diseases, but its long acquisition time makes it a time-consuming and expe...
The COSI study: a multi-site RCT to explore the clinical and cost effectiveness of the Circle of Security Intervention for mothers in perinatal mental health services
Research question: Is the Circle of Security-Parenting (COS-P) intervention more effective than treatment as usual in improving symptoms of maternal mental illness and mother-infan...
Early Vitrectomy and Intravitreal Antibiotics for post-operative exogenous eNdophthalmitis (EVIAN) study: A feasibility multicentre randomised controlled trial
Research question To explore the feasibility and acceptability of carrying out a randomised clinical trial of early surgical treatment compared to standard treatment for endophthal...
MAD plus CPAP: does combining two established treatments for Obstructive Sleep Apnoea give added benefits?
Research question Does combining Mandibular Advancement Devices (MAD) with Continuous Positive Airway Pressure (CPAP) therapy make it easier for patients to tolerate CPAP; thereby...