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44,293 grants found
Showing 1,041 – 1,060 of 44,293 grants
Eflornithine for treating high-risk neuroblastoma with complete or partial response after immunotherapy [ID4060]
Neuroblastoma is a solid cancer of embryonic nerve cells called neural crest cells. It commonly occurs in the adrenal glands or in the nerve tissue of the sympathetic nervous syste...
Assessing the risks of zoonoses from the warming Arctic
The Arctic is warming - fast. This has consequences which reach beyond the Arctic, including the emerging potential for zoonoses.This project aims to deliver the first evidence dri...
The development and evolution of grain abscission in the Triticeae
Barley is an important cereal crop for the brewing industry, animal feed and human food. Domestication of barley led to a non-shattering (non-brittle) rachis, facilitating grain ha...
Understanding the role of phosphorylation in RNA polymerase II transcription
Cells must convert information encoded in DNA into protein-coding messenger mRNA, which is achieved through the action of an enzyme called RNA polymerase II (Pol II). This process...
Garadacimab for hereditary angioedema aged 12 and over [D6394]
Hereditary angioedema (HAE) is a rare genetic disorder associated with the deficiency of the protein C1-esterase inhibitor which is a regulator of inflammatory pathways.Normally C1...
Obecabtagene autoleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia [ID6347]
Acute lymphoblastic leukaemia (ALL) is a cancer of lymphocyte-producing cells. Lymphocytes are white blood cells that are vital for the bodys immune system.In ALL there is an exces...
Avelumab with axitinib for untreated advanced renal cell carcinoma (MA review of TA645) [ID6294]
Renal cell carcinoma (RCC) is a cancer that usually originates in the lining of the tubules of the kidney (the smallest tubes inside the nephrons) that help filter the blood and ma...
Preventing and Understanding CHIP Evolution into AML: The role of the LY75 in the development of DNMT3A-mutant CH and associated myeloid neoplasms
Myeloid neoplasms (MN) affect ~10 per 100,000 individuals per year and remain lethal to the majority.Most cases of MN arise from the clonal expansion of an HSC and its progeny driv...
Strengthening Climate Change and Health Thought Leadership with Africa in Focus
Climate change poses immense threats to human health and wellbeing.The sixth assessment report (AR6) of the Intergovernmental Panel on Climate Change (IPCC) highlights significant...
The Reynolds Digital Research Resource; access to rich heritage science data in its multidisciplinary context and a template for future initiatives
The project will build a digital research resource collating a rich collection of technical data from examination of paintings by Joshua Reynolds over many decades. First president...
AENEAS: Age-Enabled Exoplanet Science: Understanding the evolution and diversity of planetary systems
We have detected over 5000 exoplanets in more than 3800 planetary systems. One of the most striking features of the exoplanet population is the remarkable diversity in planet compo...
Micro-structural controls on oceanic core complex formation: IODP Exp 399 Atlantis Massif_2
The surface of the Earth is divided up into tectonic plates that have moved throughout Earth history and these plates are continually created and destroyed at the boundaries betwee...
Perception-guided Aerial Additive Manufacture: A StepTowards Closed-loop Construction with Aerial Robots
In an era marked by rapid technological advancements, the integration of aerial robots into our daily lives and environment holds immense promise.These aerial robots have the poten...
Utilising palaeobotanical data to calibrate the response of vegetation to carbon dioxide in Earth system models
Rising atmospheric carbon dioxide (CO2) concentrations alter the vegetation composition indirectly through climate change anddirectly through plant physiological modifications. Bot...
Microfluidic Technologies for the Production of Therapeutic Synthetic Cells
Synthetic cell production is at the forefront of bottom-up synthetic biology; whereby non-living building blocks (e.g. amino acids and lipids) are used to assemble cell-mimicking s...
Development of machine learning governed constitutive models for Tungsten under extreme temperature and irradiation conditions
Fusion energy can play a major role in tackling the climate emergency and the UK is committed to connect a fusion power plant to the grid by 2040.To accelerate developments in vari...
WAS - We Are Supernova: Studying and Exhibiting the Dawn of the Universe in the Silicon Chip
At a time of climate collapse, the artistic research project We Are Supernova (WAS) will offer a new analysis of the forces of perpetualgrowth that drive it. Hosted by Goldsmiths C...
Cultural Heritage, People and Place: Understanding value via a regional case study
The Cultural Heritage, People and Place: Understanding value via a regional case study project addresses the AHRC DCMS call Research culture and heritage capital with an interdisci...
Pumping iron: exploring a novel iron transporter in the early life microbiota member Bifidobacterium
Introduction: We have a hidden universe inside our bodies - the gut microbiota! This exciting world of tiny organisms may hold the key to helping infants that have iron deficiency...
Thromboplastics - How microplastic particles impact the vascular and haemostatic systems
The reliance of the human race on plastic materials has now resulted in a global pandemic where billions of ton of plastic waste have been deposited.As this degrades, micro-plastic...