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44,293 grants found
Showing 1,381 – 1,400 of 44,293 grants
Targeting monocyte differentiation for cancer immunotherapy
Dendritic cells (DCs) comprise a heterogeneous population of antigen- presenting cells that play a critical role in driving the adaptive immune response.We have recently reported t...
Planktonic drivers of gill disease in farmed Atlantic salmon: from mechanisms to solutions
Atlantic Salmon aquaculture in the UK is facing an existential threat in the form of poor gill health. Losses are mounting every year, threatening the viability of an industry that...
ARCHCROP: Crossing Paths: Millet, Wheat and Cultural Exchanges in the Inner Asian Mountain Corridor, China
The Bronze Age (3rd to 2nd millennia BC) witnessed the spread of millet consumption westwards from China, while southwest Asian crops (wheat and barley) spread eastward. These cros...
Lost Souls, White Bowls: Documenting Vietnamese femicide through research, film and participatory ceramic art
Gender-related killings (femicide/feminicide- an intentional killing with a gender-related motivation) are the most extreme manifestation of violence against women and girls (UN Wo...
Generating Evidence to Improve the Health and Well-being of Low income Migrant Workers from South Asia
International labour migration exposes migrant workers to physical and mental illnesses and deaths (Carruth et. al. 2021, Moyce & Schenker 2018, Castaneda et. al. 2015).Beyond...
Improving barley climate resilience using a candidate gene approach
Rising temperatures brought about by climate change are major threat to agriculture and food security: in wheat and barley, each 1C increase above optimal growth temperature is est...
Chemical and isotope identification through highly sensitive spectroscopy
We will develop new kinds of spectrometers based on high throughput Fourier-transform techniques and compressed sensing.The Fourier-transform idea uses birefringent optics to creat...
Targeted induction of the cold-shock protein RBM3 to prevent synapse loss and neurodegeneration in ALS/FTD
In MND the connection between different nerve cells, synapses, are lost very early on, even before any clearly visible disease symptoms.The aim of this project is to establish whet...
Treating the autonomic neural pathobiology of a devastating early onset genetic urinary bladder disease
Three million people in the UK have a rare disease, a topic the NHS is now urgently addressing, with personalised medicines such as gene therapy envisaged as eventual gold standard...
Ionic liquids for subtractive and additive nanomanufacturing
I propose investigating the use of ionic liquids for materials treatment, specifically in nanotechnology. Nanotechnology is the manipulation of matter at molecular scales close to...
3DxN - Scalable Multiplexed 3D Tissue Imaging
The analysis of tissues plays a central role in advancing our understanding of ageing and disease.The scientific discipline of cellular pathology has been recognised as significant...
Pembrolizumab with pemetrexed and cisplatin for untreated advanced malignant pleural mesothelioma [ID4044]
Malignant pleural mesothelioma is a cancer affecting the membranes lining the outer surface of the lungs and the inside of the chest wall (the pleura).It is a highly aggressive tum...
Pembrolizumab with enfortumab vedotin for untreated metastatic urothelial cancer [ID6332]
Urothelial carcinoma is cancer of the transitional cells which form the inner lining of the bladder urethra ureter or renal pelvis.Urothelial carcinoma accounts for approximately 9...
Novel Electric Actuator for Aerospace Applications
The research will focus on the application of Systems Engineering methodologies for the design and development of future novel electric actuators to support engineering Net Zero an...
CHAC Side event: Ministerial Meeting on Climate and Health in Africa
The Ministerial Meeting on Climate and Health in Africa, held as a side event at CHAC 2024, will address the urgent need to boost climate resilience in Africa's healthcare sys...
Molecular based patient stratification for the personalization of giant cell arteritis management
This project seeks to transforming the care of a prevalent but commonly ignored medical condition called Giant Cell Arteritis (GCA).GCA is an inflammatory disease which is consider...
DAR3T: Data Analysis of 3Rs Tools
Technological advances including high throughput sequencing, imaging and spatial technologies, have led to the establishment of large public-domain cancer data collections, derived...
A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacement
We aim to establish the most comprehensive, world-class organ-chip facility in the UK, make it accessible as a community resource, and use it as a platform to advance organ-chip de...
Scaling up human pluripotent stem cell delivery and distribution facilitating reduction in animal use
Human pluripotent stem cells can be maintained in culture dishes and directed to differentiate into almost any cell type.These cells are therefore powerful tools for studying human...
A core facility for human induced pluripotent stem cells for neurological disease
Our understanding of neurological disease and the development of new treatments has been hampered by the inaccessibility of the human central nervous system during life and the lac...