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44,293 grants found
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Bridging The Dual Facets of Working Memory: Causal Mapping of Active and Hidden States Using Brain Stimulation and Precision Imaging
In human cognition, working memory (WM) plays a pivotal role, allowing us to “actively” focus on limited information while also maintaining a broader "hidden" cognitive b...
Global Antibiotic Policy initiative – GAPi
Antimicrobial resistance is responsible for significant mortality and economic harm.There is an urgent need to guide decision making around implementation of interventions aimed at...
Making the margins visible: quantifying intersectional inequalities in youth mental health across time and place
Existing research in youth mental health inequalities has primarily focused on differences across single social categories such as gender, ethnicity, sexuality, and socioeconomic p...
Understanding Mesenchymal Tissue Mechanics via Nanorobotics
Cells interpret and modify tissue mechanics to regulate behaviours such as migration and differentiation in development and disease.A prominent example is the epithelial-mesenchyma...
Spatiotemporal investigation of the MuvB/DREAM pathway in cell cycle gene expression programs
The cell cycle is the fundamental biological process where the cell coordinates chromosome replication and segregation with cell growth and division. Cell cycle exit controls cell...
Discovering how CpG islands control transcription to regulate gene expression
The remarkable process of multicellular development requires that cells initiate and then maintain highly-defined gene expression programs.We have recently discovered that CpG isla...
When DNA becomes its own enemy: How DNA impacts replication dynamics, fidelity, and integrity
Every dividing cell in our body accomplishes a remarkable feat – copying an entire genome without a single mutation on average.Perturbations of genome replication, collectively ter...
Olfactory plasticity for adaptation and learning
Neurons can modify themselves in response to environmental changes in a process called neuronal plasticity, which is thought to be the basis of adaptation and associative learning....
Climate Change Resilient Equitable Healthy Cities in Africa (CLARITY-Africa)
Our programme aims to generate novel transdisciplinary knowledge and trigger policies and practices that enhance resilience and adaptive capacity to the health effects of climate c...
Assembly of the meiotic spindle in the large oocyte volume
Chromosome mis-segregation is frequent in human meiotic oocytes and a major cause of infertility, miscarriage and congenital conditions, such as Down syndrome. Chromosome segregati...
Extended linkage of data to understand causes of serious adverse neonatal outcome in pregnancy complicated by pregestational diabetes in Scotland
In Scotland, pregnant women with type 1 (T1DM) or type 2 diabetes (T2DM) are at higher risk than women without diabetes of serious adverse outcomes.They are 5x more likely to exper...
Optical Oscilloscope: Real-time, High-throughput, Volumetric Voltage Imaging
Subthreshold voltage conveys information about neuronal connectivity, network and neuromodulatory states critical to understanding brain circuit function and dysfunction.Unlike spi...
Removing Barriers to Fungal Bioimaging for the Global Medical Mycology Community
Human fungal pathogens cause 2.5 million deaths each year, primarily in low and middle income (LMIC) countries. The WHO identified 20 Priority Fungal Pathogens requiring urgent fun...
Understanding and enhancing the physiological resilience of older adults to improve health-span: a focus on skeletal muscle
‘Loss of resilience’ describes enhanced vulnerability to, and impaired recovery from stress events when compared to a robust [youthful/healthy] state; and is commonly encountered w...
Aston Brain Health Cohort Study (ABaHCoS): Detection of dementia risk to support independent living
The Aston Brain Health Cohort Study (ABaHCoS) will provide fundamental research underpinning a novel suite of easy-to-access tests that together estimate an individual’s brain heal...
Medicines in an ageing society – an interdisciplinary research programme: MED-AGE
Medicines use in older people has been described as the ‘single most important health care intervention in the industrialised world’ (13).Medicines have contributed enormously to m...
Integrating rehabilitation and palliative care to optimise function for older people: The Dunhill Medical Trust – Saunders PhD Programme
Context and overview Globally, more people are living into old age, with increasing disease, multimorbidity and/or frailty, and a trajectory of prolonged, unpredictable functional...
Validation of non-animal derived products for stem cell-derived breast cancer organoid models
This project aims to validate the use of non-animal derived products used for the differentiation of organoids derived from induced pluripotent stem cells (iPSCs) to model breast c...
Developing an intervention to support discussion between mental health staff and patients after a Mental Health Act assessment
Background Being detained in a mental health hospital is the most ethically contentious area of mental health.With growing concern about the increasing number of detentions and poo...
Measuring Additional Generalised Impacts on Cardiovascular outcomes (MAGIC) model for diabetes
Research question To develop and validate a new economic model to inform current type 2 diabetes (T2D) health policy using patient-level cardiovascular outcomes trials (CVOT) data....