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Direct Replacement of Secondary Antibodies by Affimer proteins in Lateral Flow Devices.
Antibodies are the gold standard for affinity reagents in therapy, research and diagnostics.While monoclonal antibodies can be produced by hybridoma cell lines or recombinantly, po...
Characterisation of antibodies and affinity reagents to promote the adoption of robust and reproducible non-animal reagents
Affinity reagents such as antibodies are used in most biomedical research labs to study proteins. Currently, the most used affinity reagents are animal-derived polyclonal and monoc...
Multi-laboratory validation of a new animal product-free test guideline addition for the in vitro micronucleus test (TG487)
Scope: This project aims to conduct a multi-laboratory validation of an animal-product free methodology adaptation to an established OECD test.Using this standard, widespread assay...
Validation of Scinora serum-free media formulations and Xplace supplement for the development of animal-free NAMs for nanotoxicology
The expanding development of new nanomaterials (NMs), particles 1000-times smaller than the width of a hair, has led to an increase in the number of materials which require robust...
The Role of Platelets in Trauma-induced Organ failure
Organ failure occurs frequently after major trauma, but the cause is unknown and there are no specific treatments.I hypothesise that platelets drive a dysregulated immune response...
Working with young people to transform understanding of how sex and sexism cause anxiety in teenage girls and young women: international, interdisciplinary & intersectional approaches.
Our team includes social scientists, neurobiologists, and young people from the UK and Japan.Our vision is a world in which girls/women are no longer three times more likely than b...
Understanding the neural mechanisms of mating in malaria mosquitoes
In 2021, globally there were 247 million cases mosquito-borne malaria, resulting in 593,000 deaths. Despite its global health priority, the neuroscience of mosquito mating behaviou...
The role of underheated homes in preschool respiratory infections: A national epidemiological and natural experiment study using linked data.
Acute respiratory infections (ARIs) are the main cause of hospitalisations in preschool children and increase the risk of asthma and premature adult death.ARIs are associated with...
Lipid homeostasis disruption in DYT-TOR1A dystonia
Dystonia is the third most common movement disorder characterised by painful involuntary muscle contractions that disrupt coordinated locomotion.However, the neuronal dysfunction t...
Assessing the potential epidemiological impact and cost-effectiveness of a status-neutral HIV care approach integrated with other sexual health services for adolescents and young adults in South Africa: a mathematical modelling study
In South Africa, despite freely available and effective HIV treatment and prevention, 210,000 new infections and 51,000 deaths occurred in 2021.Sexually active adolescents and youn...
From novel biology to clinical strategy: Targeting the M5-muscarinic acetylcholine receptor in opioid addiction
The world is facing an opioid crisis of epidemic proportion.Within the United States >4% of the adult population currently misuse prescription opioid analgesics whilst in the UK...
Centromeric Recombination: friend or foe?
Accurate cell division is imperative for organism development, At the heart of this critical process lie the centromeres, pivotal in orchestrating kinetochore assembly and ensuring...
Clonal and functional T cell determinants of protection and pathogenesis in tuberculosis.
Tuberculosis (TB), resulting from infection with Mycobacterium tuberculosis (Mtb), kills 1.5 million people per year.The immune system prevents disease in most people who become in...
Olfactory communication in the first weeks of life: from chemical mechanisms to improving breastfeeding outcomes
Successfully latching onto the mother's breast is critical for infant survival, growth, and health, while also enhancing bonding and maternal wellbeing.However, breastfeeding...
Optical Functional Imaging For Metabolic Cell Model Engineering and Profiling
Spatial-temporal regulation of cell-signalling, and metabolism is crucial to maintain function within cells and tissues.In this proposal we will develop advanced microscopical tool...
Multimodal, multiscale functional tissue state imaging
Human biology is highly complex and despite advances in technology development, we lack an understanding of how the many thousands of molecules and features of a cell make up a tis...
Dunhill Medical Trust Doctoral Training Programme for Ageing Research
The DTP for Ageing Research in Exeter will focus on two main areas and here we provide examples of potential PhD projects. (1) Improving our understanding of the mechanisms of agei...
R1: Role of embodiment in common-sense reasoning
TBC
Revealing the spatial distribution of quantum states in materials for quantum technologies: quantum crystallography of defects
Both electron and X-ray diffraction have been used to not only determine the positions of atoms in materials, but also to detect charge density changes due to bonding. This has bec...
Functional genomics to unveil the early intra-mammalian development of schistosomes
The Neglected Tropical Disease schistosomiasis affects more than 250 million people in Low and Middle-Income Countries, where more than 600 million are at risk. The disease, caused...