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201,169 grants found
Showing 200,581 – 200,600 of 201,169 grants
Obesity: From Cell to Patient
ABSTRACT Support is requested for a Keystone Symposia conference entitled Obesity: From Cell to Patient, organized by Drs. Kevin L. Grove, Rachel L. Batterham and Shane T. Hentges....
Data Science to Power Implementation with Social Determinants of Health - from Data to Action
Specific aims Our overall goal is to build multidisciplinary networks around data and implementation science to drive science and translation, and advance improvements in the devel...
The neural foundations of regulation in infancy and the role of individual and environmental factors over time
Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for psy...
Mechanisms of long-term maintenance of lung tissue-resident memory CD8 T cells
Project Summary/Abstract: Despite the availability of a seasonal vaccine, influenza virus remains a critical burden to human health, infecting millions worldwide every year.The lim...
Activity-Dependent Mechanisms of Memory Consolidation
PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world.This project investigates how motor learning...
The role of carbohydrate binding module cooperation in BaAmy7 hydrolysis of resistant starch
The gut microbiota plays a major role in colonic health and homeostasis. The growth of beneficial bacteria can be promoted by the administration of prebiotics in the human diet.Res...
Structure-Function Relationship of the Extracellular Matrix Proteome in Congenital Aortic Valve Stenosis
Project Summary This proposal focuses on novel molecular mechanisms underlying aortic valve (AV) development in health and disease.The preliminary data presented in this proposal s...
Impact of heme catabolism on triple negative breast cancer metastasis via immune-suppression
Abstract/Project Summary Triple negative breast cancer (TNBC) has more frequent and rapid metastasis than other breast cancer (BC) subtypes and >20% of patients progress on stan...
Repurposing Endonuclease V for the detection and engineering of adenosine-to-inosine editing
Project Summary/Abstract RNA editing is a widespread strategy employed by cells to post-transcriptionally alter protein sequence and gene expression levels.Adenosine-to-inosine (A-...
Synergistic Material-Microbe Interface towards Faster, Deeper, and Air-tolerant Reductive Dehalogenation
Project Summary/Abstract Challenges exist in bioremediation of halogenated contaminants, including low donor utilization efficiency and slow dehalogenation, low dehalogenation acti...
Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making
Project Summary/Abstract Large-Scale Mapping of Striatal Dynamics during Perceptual Decision Making The accumulation of evidence over time is a critical aspect of many types of dec...
A Convergent Approach to the Synthesis of Auriculatol A
PROJECT SUMMARY The grayanane diterpenoids are a class of structurally complex natural products that have compelling biological activity but are challenging to synthesize de novo i...
COVID-19: Characterizing trained immune responses to COVID-19
In late 2019, a novel human betacoronavirus emerged in Wuhan, China and subsequently led to pandemic spread.Designated Severe Acute Respiratory Virus 2 (SARS CoV-2), this virus has...
Elucidating Oncogenic Mechanisms Underlying Wilms Tumor Using Kidney Organoids
PROJECT SUMMARY/ABSTRACT Wilms tumor is the most common pediatric kidney cancer.Blastemal-predominant tumors are classified as high-risk and have demonstrated resistance to chemoth...
Elucidating mechanisms for enhanced anaerobic bioremediation in the presence of carbonaceous materials using an integrated material science and molecular microbial ecology approach
PROJECT SUMMARY: Halogenated compounds, including legacy pollutants (e.g., chlorinated ethenes (CEs), polychlorinated biphenyls) and emerging contaminants (e.g., 1,2,3-trichloropro...
Investigating the Role of KIBRA-Dependent Synaptic Function on Hippocampal and Cortical Network Mechanisms Underlying Complex Cognition
Project Summary Revealing how molecular interactions within single cells contribute to experience-dependent changes in circuit- level neural activity across large-scale brain netwo...
Experience-dependent Cellular Plasticity Mechanisms
Brain activity is essential for the development and plasticity of neurons and circuits, however our understanding of the mechanisms by which activity generates functional circuits...
Biomimetic size-adaptable heart valve for prosthesis-patient mismatch
ABSTRACT The overall goal of this Phase I STTR project is to develop a biomimetic size-adjustable prosthetic heart valve (Autus Size-Adaptable Valve) that can be expanded post-impl...
Dissociable neural mechanisms of reactive versus appetitive aggression
Project Summary Maladaptive aggression characterizes - or is comorbid with - many neuropsychiatric illnesses, and can have devastating effects on individuals, their caretakers, and...
Function of Kdm4dl-mediated heterochromatin removal in the preimplantation mouse embryo
PROJECT ABSTRACT This project will investigate the function of a currently unstudied histone demethylase, Kdm4dl, in the mouse preimplantation embryo.Many others have shown the dev...