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201,169 grants found
Showing 201,041 – 201,060 of 201,169 grants
Population-Targeted Risk Prediction to Guide Breast Cancer Screening in Cameroon
Project Summary/Abstract: As cancer becomes an increasingly important cause of mortality in sub-Saharan Africa, nations must improve their capacity to diagnose and treat the malign...
Characterizing the effects of cis-regulatory variation on patient outcomes and treatment response in Multiple Myeloma
ABSTRACT Multiple Myeloma (MM) is a malignancy of plasma cells and the second most common hematological cancer accounting for 2% of cancer deaths. MM is associated with a poor prog...
A Convergent Approach to the Synthesis of Auriculatol A
PROJECT SUMMARY The grayanane diterpenoids are a class of structurally complex natural products that have compelling biological activity but are challenging to synthesize de novo i...
Control of Colitogenic Th17 cells by Vitamin D Receptor Signaling
PROJECT SUMMARY Vitamin D (Vit D) deficiency is estimated to affect over 1 billion people worldwide and is now considered a global health crisis. In addition to maintaining calcium...
Determining the molecular basis of chemosensory behaviors in mosquito-borne filarial nematode parasites
Project Summary During infection and transmission, the larvae of mosquito-borne filarial nematode parasites perform patterned migrations, likely using a variety of sensory modalitie...
Use of novel methods to study the biochemical mechanisms of ACTG2 mutations in visceral myopathy
Project Summary The goal of this proposal is to study the mechanisms by which mutations in gamma smooth muscle actin (ACTG2) cause visceral myopathy by building upon newly develope...
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an est...
Creating natural product diversity via the fabrication of a hybrid fatty acid-nonribosomal peptide synthetase
Abstract: Natural products and derivatives/mimics of natural products make up the majority of modern therapeutic drugs due to their unique complex organic scaffolds that contribute...
COVID-19: Characterizing trained immune responses to COVID-19
In late 2019, a novel human betacoronavirus emerged in Wuhan, China and subsequently led to pandemic spread. Designated Severe Acute Respiratory Virus 2 (SARS CoV-2), this virus ha...
CMA: Network plasticity in acquired epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and a major source of disability in the veteran population as it is frequently caused by war-time head in...
Pathologic Signaling Pathways in AML Cells
Abstract: Acute myeloid leukemia (AML) is a serious blood cancer that affects United States Veterans and other individuals. Multiple studies have demonstrated that active signaling...
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
ABSTRACT Chronic sleep disturbance is a frequent and challenging problem of human aging. In the US an estimated 39.6 million people including 8.5 million Veterans are aged 65 or ol...
A role and regulation of glucose responsive lipolysis in pancreatic beta cells
T2D is a major health problem for US veterans that imposes significant physical, financial, and emotional tolls. Thus, there is a strong and urgent need for an effective and widely...
Dynamics of protein kinase CK2 signaling in prostate cancer pathogenesis
Prostate cancer (PCa) is one of the major health issues for the aging Veterans population warranting investigations to further advance knowledge of the disease pathobiology and ben...
Cholangiocyte-Derived Endothelin Signaling Mediates Biliary Injury and Liver Fibrosis
The main goal of this application is to clarify the signaling mechanisms mediating biliary senescence and angiogenesis during primary sclerosing cholangitis (PSC). It is known that...
Identifying the role of MrgprB4-lineage neurons in social touch and oxytocin circuit activation
PROJECT SUMMARY The rewarding nature of social touch is critical for communicating physical and emotional support, and can even be anxiolytic in therapeutic forms of touch such as...
Veterans Affairs - Translational Education and Mentoring (VA-TEAM) Center
Agencies that fund medical research are under increasing pressure to translate funded research projects to commercial entities. These commercial entities can obtain the necessary e...
Alterations in Ventral Hippocampal CA1 Processing as a Mechanism for Anxiety in Alzheimer’s Disease
PROJECT SUMMARY/ABSTRACT Anxiety is a highly prevalent and burdensome symptom of Alzheimer disease (AD), especially at early stages, and is linked to faster decline. Further mechan...
The neural foundations of regulation in infancy and the role of individual and environmental factors over time
Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for psy...
Mechanisms of immune evasion by a neuroinvasive fungal pathogen
Project Summary Cryptococcus neoformans is a neuroinvasive yeast that causes fatal meningitis in immunocompromised individuals, resulting in >180,000 annual deaths representing...