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201,169 grants found
Showing 201,061 – 201,080 of 201,169 grants
Transcriptional Control of Skeletal Muscle Atrophy
Skeletal muscle atrophy results from insufficient nutrition, aging, certain medications, and a wide range of medical illnesses including cancer, diabetes mellitus, heart or renal f...
Neural Substrates of Binge Drinking
Alcohol misuse is responsible for ~88,000 deaths annually and exerts an annual cost of ~$250 billion in the US. Binge drinking, which accounts for ~75% of these costs, is defined b...
Mechanism of Vascular Impairment in Neurocognitive Disorders
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly including veterans. Since proportion of the elderly population is progressi...
Host factors affecting susceptibility to Candida auris.
This VA Merit research project aims to define host factors associated with mucosal infection by an emerging multi-drug resistant human fungal pathogen, Candida auris. Most human fu...
Traumatic Brain Injury and Vascular Disease
Objective: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the veteran population. In the United States, there are an estimated 5.3 million people livi...
Foxp transcription factors in regulatory T cells
Regulatory T cells (Tregs) are critical for actively maintaining immune tolerance. The Foxp family of transcription factors is composed of four members; Foxp1, Foxp3 and Foxp4 are...
Epigenetic regulation of stem cells and development by the DNA dioxygenase Tet2
ABSTRACT The Ten-eleven translocation (Tet1/2/3) family of enzymes are epigenetic regulators of gene expression important for stem cell biology and embryonic development. Tet enzym...
Determing the genetic basis of responses to biomechanical strain in an in vitro model of osteoarthritis
Osteoarthritis (OA), a degenerative joint disorder characterized by articular cartilage damage and alterations to the structure of subchondral bone, is the most common joint diseas...
Genetic analysis of lung cancer susceptibility
Abstract Although tobacco exposure is the major determinant of lung cancer, only about 15% of smokers develop lung cancer. In this study, we seek to identify genetic effects that i...
Structure-Based Design of Peptide Entry Inhibitors against Ebola Virus Infection
Abstract Ebola viruses (EBOV) along with Marburg viruses (MARV) belong to the Filoviridae family which infects humans and nonhuman primates and causes outbreaks with a high mortali...
Estrogen Receptor Signaling in the Expression of Respiratory Motor Plasticity
PROJECT SUMMARY/ABSTRACT The respiratory control system displays a remarkable capacity for neuroplasticity, imparting flexibility of breathing in response to changing physiological...
The Role of Medial Prefrontal Cortex in the Memory for Sequences of Events
PROJECT SUMMARY/ABSTRACT Temporal organization is critical to many perceptual, cognitive, and behavioral functions. These temporal abilities are adversely impacted in several menta...
Investigating the Role of KIBRA-Dependent Synaptic Function on Hippocampal and Cortical Network Mechanisms Underlying Complex Cognition
Project Summary Revealing how molecular interactions within single cells contribute to experience-dependent changes in circuit- level neural activity across large-scale brain netwo...
Complexity and the Wound Healing Response
Project Summary The ability to heal is essential for human health. The remarkable wound healing capacity of humans (and indeed of all animals) is a complicated process. Genomic stu...
Advancing Ultraviolet Photodissociation Mass Spectrometry for Precision Mapping of Protein Glycosylation
PROJECT SUMMARYGlycosylation plays a structural and functional role in all fundamental features of proteins in cells. Despite substantialevidence suggesting O-glycosylation is vita...
A Novel Presynaptic Role for MHCI in Regulating Cortical Synapse Formation
Project Summary For years, researchers have observed evidence of cross–talk between the immune system and the nervous system, but the idea that immune molecules play non-immune rol...
COVID-19: Elucidating the Role of the NasalEpithelium in SARS-CoV-2 Infection, Transmission, and Prevention
ABSTRACT Severe acute respiratory syndrome coronavirus SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) has led to a pandemic with a mortality of approximatel...
Colon cancer nanotherapy targeting STRAP
Although activation of the Ras/Raf/MEK/ERK pathway is involved in cell growth, inhibition of apoptosis, induction in stem-like phenotype, and drug resistance, little is known about...
Defining Breath VOC Biomarkers to Improve Respiratory Health of Exposed Veterans
The goal of this resubmitted application is to define signature exhaled breath volatile organic compounds (VOCs) in veterans exposed to toxicants and to develop an effective portab...
Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches....