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201,169 grants found
Showing 201,101 – 201,120 of 201,169 grants
Efficient Bioremediation of Environmentally Persistent Contaminants with Nanomaterial-Fungus Framework (NFF)
Project Summary The recalcitrant and harmful chemicals such as PFASs (per- and polyfluoroalkyl substances), endangers the environmental, wild-life, and human health profoundly. Amo...
Understanding rhythmic gene regulatory mechanisms in the mammalian circadian system
Summary Circadian rhythms are biological, physiological, and behavioral processes that enable organisms to respond to the environmental changes caused by the rotation of the Earth....
Defining the Mechanism and Function of DNA Double Strand Break Induced Inhibition of V(D)J Recombination
Project Summary: B cell-mediated adaptive immunity relies on the programmed induction of DNA double strand breaks (DSBs) to create diverse immunoglobin (Ig) gene repertoires. The R...
Structural and Functional Studies of HER Receptors
PROJECT SUMMARY/ABSTRACT Receptor tyrosine kinases (RTKs) are activated by extracellular ligands to transduce the bulk of the signals that control cellular growth, proliferation an...
Role of membrane-associated macrophages in health and inflammation
PROJECT SUMMARY/ ABSTRACT Mesenteritis is an inflammatory disorder of mesenteric tissues. It includes mesenteric lipodystrophy (mesenteric fat necrosis), mesenteric panniculitis (c...
Fine-Mapping Genome-Wide Associated Loci using Multi-omics Data to Identify Mechanisms Affecting Serious Mental Illness
Genome-wide association studies have been key for identifying genetic variation associated with psychiatric disorders. Whenever these GWAS are based on large sample sizes, however,...
Determining the role of macrophages in the developing cardiac conduction system
PROJECT SUMMARY/ABSTRACT Macrophages are well-characterized as sentinel immune cells that coordinate cellular responses to injury and infection. However, emerging evidence demonstr...
Engineering Modular Oxygen-generating, Pro-vasculogenic Biomaterial Platforms for Cell-Based Therapies
PROJECT SUMMARY/ABSTRACT In this proposal, we aim to develop two distinct biomaterial systems for improving nutrient and oxygen availability within cell-based clinical islet transp...
A novel class of long non-coding RNA in regulation of the type I interferonresponse
Project Summary The mammalian genome is pervasively transcribed to generate a complex non-coding transcriptome. A novel class of long non-coding RNA (lncRNA) called DoGs for “Downs...
Identification of Flavivirus Nucleocapsid Core-Envelope Glycoprotein Interactions
Project Summary/Abstract Flaviviruses (a family of over 90 known viruses, including Zika, dengue and West Nile) are significant human pathogens affecting 3.1 billion people annuall...
Validation of Smartphone-Derived Digital Phenotypes for Cognitive Assessment in Older Adults
PROJECT SUMMARY/ABSTRACT At present, one in 10 Americans age 65 and older has Alzheimer's dementia. Further, the global prevalence of dementia is expected to triple from 50 mi...
Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memory
PROJECT SUMMARY/ABSTRACT The hippocampus is a critical brain region for various types of learning and memory, and one powerful paradigm to investigate hippocampal function in assoc...
A Precision Medicine Approach To Study Targetable Pathways in Vascular Dementia
Dr. Elahi is an early career physician-scientist with specialty training in neurodegenerative disease and experience in biomarker development, who seeks to develop her career at th...
Accelerating collaborative, cumulative, and open intervention science with an e-intervention authoring platform
Background. Research has identified a wide range of evidence-based interventions for key behavioral health risks such as poor diet, smoking, unhealthy alcohol use, or a sedentary l...
Motherhood Biographies and Midlife Women's Health
Abstract The Motherhood Biographies and Midlife Women’s Health R01 project maps how divergence in motherhood experiences contributes to growing midlife health disparities. About 85...
Neuromodulation of long-term sequelae of ischemic acute kidney injury
Project Summary Acute kidney injury (AKI) is recognized as a major risk for progressive chronic kidney disease (CKD). However, the mechanism by which AKI leads to fibrogenesis and...
Determining the Mechanism of Transformation for Rhabdomyosarcoma
ABSTRACT Rhabdomyosarcoma (RMS) is an aggressive, soft-tissue sarcoma in children. While many clinical trials have worked to improve patient outcomes, the 3-year survival rate for...
Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission within the Veterans Affairs (VA) Health Care System. It is associated with severe impairment of...
Identification of novel phosphodiesterase (PDE)-modulating compounds and characterization of associated cytoprotective pathways in lightdamagedretina
PROJECT SUMMARY Cyclic nucleotide phosphodiesterases (PDEs) are a class of enzymes ubiquitously expressed in the human body, and they play a critical role in a broad range of physi...
The role of a Legionella pneumophila gene cluster during infection of mammalian hosts
Project Summary / Abstract Infections caused by intracellular bacteria pose a substantial threat to global health by subverting the immune system to replicate inside host cells. Le...