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201,169 grants found
Showing 196,601 – 196,620 of 201,169 grants
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
Elucidating the role of NK cells in Lewy body diseases
PROJECT SUMMARY/ABSTRACT Lewy body diseases including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy are characterized by the accumulation of...
Targeting cholesterol metabolism and replication stress response in cancer therapy
Project Summary: Lung cancer is the leading cause of cancer deaths in both men and women. Non-small cell lung cancer (NSCLC) accounts for large majority of lung cancer diagnoses, a...
Unraveling the role of HLA-B51/ERAP1 in Behcet's eye disease
ABSTRACT / PROJECT SUMMARYHLA-B*51 in epistasis with the ERAP1 haplotype Hap10 confers the strongest currently known risk for Behcet’s Disease (BD) and Behcet’s Eye Disease (BED),...
The Regulation of Orai1 and STIM1 by Dynamic S-Acylation
Abstract Store operated calcium entry is an essential process for proper T cell activation and development. The two proteins that facilitate this process are Orai1 and STIM1. Orai1...
MicroRNA as a target for fetal hemoglobin inducing agents in sickle cell disease
My long-term research goal is to develop effective pharmacological interventions that can alleviate disease progression and improve the quality of life for patients with sickle cel...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Addressing Health Disparities Among Recent Latinx Immigrants Using a Syndemic Approach
Project Summary/Abstract Over the past decade, there has been a shift in Latinx immigration patterns to the U.S. (76% increase of immigrants from Venezuela; 37% increase of immigra...
Functionally specialized components of disease heritability in ENCODE data
PROJECT SUMMARY/ABSTRACT Genetic discoveries from genome-wide association studies have led to important insights on human disease mechanisms. In particular, disease-associated vari...
Reactivation of Chronic Toxoplasmosis
Project Summary/Abstract Toxoplasma gondii is a widespread parasite of animals that cycles between cats, which shed infectious oocysts in their feces, and a variety of animals that...
High throughput CRISPR-mediated functional validation of regulatory elements
Project Summary The overarching goal of the proposed study is to functionally characterize a large number of candidate functional elements in the mammalian genome.The ENCODE projec...
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...
Analysis of functional genetic variants in RNA processing and expression
Project Summary The goal of this project is to functionally annotate genetic variants in post-transcriptional regulation of RNA expression, which extends and complements the curren...
Capacity limits in the neural circuitry of visual word recognition
Project Summary / Abstract For most literate adults, reading feels effortless. However, visual word recognition is a complex process performed by specialized circuits in the brain,...
ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive Sites
ABSTRACT The overall mission of this Mapping Center is to create and disseminate open access, comprehensive, high-quality, high-resolution reference maps of...
CTSA Program: Admin Supplements for Quality Assurance/Quality Control Position
University of Florida QA Admin Supplement Project Summary In February 2016, NCATS provided guidance regarding the need for CTSA grantees to seek prior approval for all pilot and KL...
Engineering AAV capsids for enhanced transduction of skeletal muscle
ABSTRACT We are developing an improved adeno-associated virus (AAV)-based gene therapy vector that we call ?enhanced AAV? or ?eAAV? for short. eAAV is specifically designed for gen...
TMS effects on circuit plasticity and drug seeking in mice.
Project Summary/Abstract Drug addiction is a leading cause of morbidity and mortality in the US.Opioid addiction in particular has become an epidemic with unprecedented overdose fa...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Spatial and nonspatial knowledge
Project Summary The ability to navigate from one place to another is essential for a flourishing and autonomous human life. Cognitive scientists have long believed that navigation...