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201,169 grants found
Showing 196,621 – 196,640 of 201,169 grants
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
PROJECT SUMMARY/ABSTRACT This project aims to disseminate validated technologies and resources of the National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego to...
Merging machine learning and mechanistic models to improve prediction and inference in emerging epidemics
PROJECT SUMMARY When an outbreak of an established or emerging infectious disease occurs we ask a standard set of questions that are critical to a lifesaving public health response...
Novel Small Molecule Anti-Inflammatory Eye Drops for Ocular Graft Versus Host Disease
SUMMARY Ocular graft versus host disease (OGVHD) is a severe ocular surface inflammatory disease (OSID), occurring in patients undergoing allogenic hematopoietic stem cell transpla...
Identifying Patient Subgroups That Are Most Likely To Benefit From Medications Used To Treat Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to provide Dr. Joshua Wallach, an Assistant Professor of Epidemiology at the Yale School of Public Health, with the prot...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
The role of obscurin and Obsl1 as key determinants for diastolic function
Project Summary: The role of obscurin and Obsl1 as key determinants for diastolic function Cardiovascular disease (CVD) remains a leading cause of mortality in the US, with heart f...
Gender-based differences in non-HIV STI testing among sexually active transgender and nonbinary persons: Bridging gaps in STI research
PROJECT ABSTRACT Research suggests that transgender (trans) populations, a diverse group of persons whose gender identity and/or expression differ from societal expectations associ...
Commensal control of C. difficile virulence
Abstract: Clostridioides difficile, the etiology of pseudomembranous colitis, causes substantive morbidity, mortality and close to $5 billion/year in US healthcare costs. Commensal...
Restoring Vision with High-Fidelity Nonsense Codon Correction
PROJECT SUMMARY/ABSTRACT Nonsense mutations cause approximately 15% of genetically inherited retinopathies and inherited human diseases in general, accounting for 2.5 to 3 million...
Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes
Project Summary The PI Batista from Yale and co-investigators (Lisi, Brown University, and Palermo, UC Riverside) will investigate allosteric pathways in the CRISPR-Cas9 system – c...
Evolutionary adaptation and spatial organization of signaling in the Mitotic Exit Network
Project Summary Sensing and processing information through signaling cascades is an essential part of cellular life. A few signaling cascades such as the MAP kinase and Hippo pathw...
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
Abstract Alzheimer’s disease (AD) affects over 5 million Americans and is expected to affect 2-3-fold more in the next few decades. AD is associated with aggregation of amyloid-bet...
Alzheimer's disease-replicated brain microphysiological system to model AD physiopathology and its influenceon gliovasculature and immune system
Abstract Two hallmarks of Alzheimers Disease are accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles, which disrupt brain function. Recent evide...
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brain
Project Summary Although functional gastrointestinal (GI) disorders (FGIDs) are the most common causes of bowel dysfunction worldwide, many patients are inadequately treated becaus...
SMART NANPs: new molecular platform for communication with human immune system and modulation of therapeutic responses
Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT SUMMARY What if healthcare providers were equipped with biocompatible, biodegradable, robus...
Mesenchymal modulation of epithelial metaplasia in lung fibrosis
Project Summary/Abstract Aberrant epithelial reprogramming can take the form of metaplasia, characterized by the appearance of mature cell types that are not normally present at th...
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
Among load-bearing implants, total hip arthroplasty (THA) is probably the most clinically successful intervention. CoCrMo alloy, a wear resistant material of choice, is typically u...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Investigating the mechanisms of erythroid lineage commitment in hematopoietic stem and multipotent progenitor populations
PROJECT SUMMARY/ABSTRACT Elucidating the underlying mechanisms of lineage specification is not only a fundamental question of biology but also has a critical implication in therape...