Browse All Grants
201,169 grants found
Showing 196,641 – 196,660 of 201,169 grants
Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression
Project Summary Carriers of the apolipoprotein E (APOE) ε4 gene are at a significantly increased risk for developing Alzheimer’s disease (AD). Although numerous theories have been...
Characterization of ILEI/LIFR Axis-induced Intracellular Signaling
Project Summary Our lab has previously identified a mechanism of transforming growth factor beta (TGFβ)-mediated epithelial-to-mesenchymal transition (EMT) in murine mammary epithe...
Investigating TLR-agonist adjuvancy in STING-activating nanoparticle cancer vaccines
Project Summary/Abstract Therapeutic vaccination against melanoma has yet to realize its clinical potential. Several phase III clinical trials assessing efficacy of vaccination aga...
Chemical Rescue of Protein Kinases for Cell Signaling Applications
ABSTRACT This is a new F32 application to develop and apply chemical rescue technology to the functional analysis of protein kinases. Protein kinases regulate virtually every aspec...
High-sensitivity Immunomagnetic System for "Liquid Biopsy" of Alzheimer's Disease
Project Summary Alzheimer’s disease (AD) is a major healthcare and social-economic burden. With effective treatment yet to be developed, the early detection at the prodromal stage...
Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing Data
PROJECT SUMMARY/ABSTRACT Growing advances in imaging and fluid-based assays of Alzheimer's disease (AD) biomarkers including amyloid, tau and neurodegeneration, confirm that A...
Determining the effects of Sox9 on the cell cycle of intestinal stem cells
Project Summary/Abstract The intestinal crypt houses diverse proliferative cells including highly proliferative Transit Amplifying cells, less proliferative active intestinal stem...
Spatiotemporal representation in ventral visual pathway
In natural vision, objects change appearance over time as they translate, rotate, become occluded or undergo complex transformations, e.g., during biological motion. In these dynam...
CSHL Network Biology Conference
PROJECT SUMMARY This proposal seeks support for the conference on Network Biology, to take place March/April 2021 to 2025, at the Cold Spring Harbor Laboratory (CSHL). This meeting...
Epstein-Barr Virus nuclear antigen leader protein in transcription regulation
Abstract: Epstein-Barr virus (EBV) associated diseases remain a huge burden in human health. As an orally transmitted pathogen, EBV infection causes infectious mononucleosis and ~2...
The role of lung lipofibroblasts in alveolar differentiation
Abstract A complication of preterm birth is underdeveloped lungs that lack surfactant and adequate gas exchange due to immature alveoli. Although recent advances have been made, th...
Central mechanisms of itch transmission
Abstract Chronic itch is an unmet medical problem associated with numerous skin, immune, and nervous diseases. An imbalance of excitatory and inhibitory transmission of itch may co...
Optical nanosensor for 3D force sensing in intact tissues of live animals
PROJECT SUMMARY Physical forces are known to impact cell functions in a fundamental way. While the study dates back some 100-years, the scientific interests have significantly incr...
Transcriptional Regulation of Lung Alveolar Regeneration
ABSTRACT The respiratory system is comprised of multiple unique and spatially distinct compartments that respond to injury and diseases states differently based on their cellular a...
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
Age-related cognitive decline (ARCD), Alzheimer disease (AD), and late-onset AD-related pathologies are linked to changes in brain structure, cell populations, synapse densities an...
Develop an Artificial Intelligence-powered Smartphone App AICaries for Caries Detection in Children
Project Summary Early childhood caries (ECC) is the most common chronic childhood disease, with nearly 1.8 billion new cases per year globally. ECC afflicts approximately 55% of lo...
Point-of-care HPV mRNA test for cervical cancer screening in low-resource settings
Abstract: There is a significant need to improve global access to cervical cancer screening. Globally, approximately 570,000 women are diagnosed with and 311,000 women die from cer...
Mobile Health Tools to Promote Health in Adults with FASD
Project Summary/Abstract Adults with fetal alcohol spectrum disorders (FASD) experience many barriers to care. Research on the effects of prenatal alcohol exposure during adulthood...
Monitoring rapid guanosine signaling during ischemia
PROJECT SUMMARY Measuring dynamic guanosine signaling at the site of focal ischemia over time remains challenging to probe with existing technology yet knowledge of the dynamics, r...
Harnessing blood clot clearance mechanisms after germinal matrix hemorrhage
Abstract Germinal matrix hemorrhage (GMH) is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with l...